Phosphorylation News and Research

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Small molecule drug may help overcome ibrutinib resistance in mantle cell lymphona

A study at The University of Texas MD Anderson Cancer Center demonstrated how a small molecule drug discovered at the institution may help overcome resistance to treatment with ibrutinib in patients with mantle cell lymphoma.

9 May 2019

Scientific research articles show that imipridones target mitochondrial function in cancer cells

Oncoceutics, Inc. announced the publication of two scientific research articles demonstrating that members of the imipridone family ONC201 and ONC212 directly activate a mitochondrial protease called caseinolytic protease P.

7 May 2019

Regular endurance exercise leads to high Nrf2 nuclear translocation, DNA binding activity

Skeletal muscle mass and function becomes progressively compromised with aging, chronic disease, and physical inactivity.

26 Apr 2019

Synthesizing Modified and Pharmaceutically Relevant Peptides

In this interview, CEM Corporation talks to News-Medical Life Sciences about using their product the Liberty Blue for Automated High-Efficiency Solid Phase Peptides Synthesis of Modified and Pharmaceutically Relevant Peptides.

From CEM Corporation - Life Science 24 Apr 2019

Key proteins can block Listeria without triggering the death of host cells

New North Carolina State University research shows that key proteins known for their ability to prevent viral infections by inducing cell death can also block certain bacterial infections without triggering the death of the host cells.

19 Apr 2019

Triple negative breast cancer develop resistance to chemotherapy by turning on molecular pathway

Researchers at The University of Texas MD Anderson Cancer Center have discovered that triple negative breast cancer cells can develop resistance to frontline, or neoadjuvant, chemotherapy not by acquiring permanent adaptations, but rather transiently turning on molecular pathways that protect the cells.

19 Apr 2019

New computational model of human kinase may provide insights for cancer drug development

Researchers have developed a computational model for human MEK1, a protein with potential as a drug target for a variety of human cancers.

4 Apr 2019

New targetable vulnerability in breast cancer cells discovered

Researchers at the University of Helsinki and Karolinska Institutet have discovered new molecular mechanisms of breast cancer cell signaling that contribute to aggressive behavior of cancer cells.

29 Mar 2019

Androgen receptor plays vital role in regulating multiple mitochondrial processes

Androgens, commonly known as male hormones, stimulate prostate cancer cells to grow. Thus, many of the drugs to target that cancer focus on stopping androgen biosynthesis or blocking the androgen receptor. This standard treatment is known as androgen deprivation therapy.

20 Mar 2019

New treatment approach could minimize brain damage caused by stroke

In a study published today in the Journal of Experimental Medicine, researchers successfully used a new approach that significantly minimized brain damage caused by stroke in mouse models.

14 Mar 2019

UNH study finds how gender-biased protein may play role in autism

Researchers at the University of New Hampshire are one step closer to helping answer the question of why autism is four times more common in boys than in girls after identifying and characterizing the connection of certain proteins in the brain to autism spectrum disorders.

12 Mar 2019

Researchers elucidate how embryonic cells and tissues respond to force

Accumulated evidence suggests that physical force plays an important role in various developmental processes of fertilized animal eggs.

8 Mar 2019

The presence of cancer-causing contaminant in popular foods

Acrylamide is described as 'extremely hazardous' and 'probably carcinogenic to humans'. Its presence in popular foods, including fried, baked, roasted and toasted potato and cereal products, as well as coffee, has become one of the most difficult issues facing the food industry, its supply chain, retailers and regulators.

5 Mar 2019