Polymerase News and Research

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Coronaviruses synthesize RNA in membrane-bound compartments

A team of researchers show that IBV viral RNA synthesis occurs within the membrane-bound compartment

10 Nov 2021

Stenoparib effectively inhibits SARS-CoV-2 variants in vitro

A new study assesses the antiviral activity of stenoparib against four SARS-CoV-2 strains.

10 Nov 2021

Cell-based viral replication system for screening of SARS-CoV-2 drugs

The current study reports a SARS-CoV-2 replicon system within stable cell lines that can be cultured with ease in a standard biosafety level 2 laboratory.

10 Nov 2021

Researchers identify safety concerns with neuroblastoma candidate drug

St. Jude Children's Research Hospital scientists looking for drugs to improve survival of children with high-risk neuroblastoma found a promising candidate in CX-5461.

9 Nov 2021

SARS-CoV-2 infection in white-tailed deer

In the current study, SARS-CoV-2 antibodies were identified in over a third of free-ranging deer in northeast Ohio.

9 Nov 2021

Pfizer-BioNTech COVID-19 vaccine is associated with lower viral load in breakthrough infections

Several vaccines have been rapidly developed to help control the COVID-19 pandemic, including the BNT162b2 vaccine (Pfizer/BioNTech). This severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine has been shown in both clinical trials and in the real world to be highly efficacious in preventing infection, symptoms, hospitalizations, severe disease, and death related to coronavirus disease (COVID-19).

9 Nov 2021

A review of antigen-detecting rapid diagnostic tests for COVID-19

Scientists conducted a systematic review of the use cases and performance of Ag-RDTs for detecting SARS-CoV-2.

8 Nov 2021

Highly-sensitive PCR-based method to detect SARS-CoV-2 variants

A team of UK-based scientists has recently developed an allele-specific probe polymerase chain reaction method that can accurately detect different variants/lineages of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in respiratory samples. Furthermore, the method can detect viral variants even in samples with low viral RNA or degraded viral RNA. The study is currently available on the medRxiv* preprint server.

7 Nov 2021

Pacific oyster as a weapon against SARS-CoV-2

According to an article published in the journal Reviews in Medical Virology, the effectiveness of mollusc-derived antiviral agents has been proven in many different laboratory and animal studies, while its efficacy against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has also been proposed by recent in silico studies.

7 Nov 2021

Oral SARS-CoV-2 Mpro inhibitor for therapeutic use

A new study describes a new small molecule compound that has shown impressive safety, tolerability, and bioavailability against SARS-CoV-2.

7 Nov 2021

Scientists create a rapid diagnostic technology to detect SARS-CoV-2

Blending experts from molecular genetics, chemistry and health sciences, researchers at the University of California San Diego have created a rapid diagnostic technology that detects SARS-CoV-2, the coronavirus that causes COVID-19.

6 Nov 2021

“Catching SARS-CoV-2 in the act” – viral infection of nasal mucosa spares nerve cells

A new study discusses the entry of SARS-CoV-2 into the respiratory and olfactory mucosa of the nasal cavity.

4 Nov 2021

Highly-sensitive PCR-based method to detect SARS-CoV-2 variants

A team of scientists has recently developed an allele-specific probe polymerase chain reaction method that can accurately detect different variants/lineages of SARS-CoV-2 in respiratory samples.

4 Nov 2021

Murine hepatitis virus as a surrogate for studying SARS-CoV-2 in food processing biofilms

Researchers from Texas A&M University inoculated MHV (SARS-CoV-2 surrogate) into a meat processing environmental biofilm and developed it on stainless steel (SS), PVC, and tiles at 7°C.

4 Nov 2021

Development of SARS-CoV-2 detection platform using surface-enhanced Raman spectroscopy

Researchers have tried to develop an innovative platform for ultrasensitive and rapid detection of SARS-CoV-2 by exploiting a variation of Raman Spectroscopy.

4 Nov 2021

Cas13 shines a light on SARS-CoV-2 variants

Now, a new study published on the medRxiv* preprint server describes and benchmarks SHINEv2, a Cas13-based nucleic acid diagnostic for SARS-CoV-2 detection. SHINEv2 combines temperature sample processing and lyophilized reagents to simplify the test procedure and assay distribution immensely.

4 Nov 2021