Premature Ovarian Failure News and Research

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Premature ovarian failure (POF) is a condition that is characterized by the ovaries ceasing to function before the age of 40. This is distinct from premature menopause as women still have an occasional period and it is possible for them to get pregnant. POF affects approximately 1 in 100 women of childbearing age younger than 40 years old.

Study finds premature menopause associated with long-term negative effects on cognitive function

Premature menopause is associated with long-term negative effects on cognitive function, suggests a new study published today (7 May) in BJOG: An International Journal of Obstetrics and Gynaecology (BJOG).

8 May 2014

Study suggests possibility of engineering artificial ovaries in lab

A proof-of-concept study suggests the possibility of engineering artificial ovaries in the lab to provide a more natural option for hormone replacement therapy for women.

27 Mar 2013

New research to rewrite textbooks on how ovaries are formed

New research from the University of Adelaide will rewrite the textbooks on how an ovary is formed, as well as providing new insights into women's health and fertility.

13 Feb 2013

Ovarian grafts can produce hormones for more than 7 years

Transplanting previously frozen ovarian tissue back into female cancer survivors can lead to long-term hormonal function and preservation of fertility, according to a new study by Samuel Kim from the University of Kansas Medical Center in the US. His work-, which shows that hormonal function was restored in five women 12-20 weeks after transplantation, and in one case lasted for more than seven years, appears online in the Journal of Assisted Reproduction and Genetics-, published by Springer.

29 Jun 2012

Gbb38 protein helps explain how cells send many long-haul messages

As they work together to form body parts, cells in developing organisms communicate like workers at a construction site. The discovery of a new signaling molecule in flies by Brown University biologists not only helps explain how cells send many long-haul messages, but also provides new clues for researchers who study how human development goes awry, for instance in cases of cleft lip and palate.

3 Apr 2012

Researchers identify mesothelin antibody that could detect early-stage ovarian cancer

Using a new approach to developing biomarkers for the very early detection of ovarian cancer, researchers at Rush University Medical Center have identified a molecule in the bloodstream of infertile women that could one day be used to screen for those at high risk for the disease — or even those with early-stage ovarian cancer.

17 Aug 2011

The AFA completes yearlong fertility educational series

The American Fertility Association is pleased to announce the completion of a yearlong fertility educational series which was funded by Attain Fertility Centers.

30 Apr 2011

Pretreatment with FDA-approved drug allows successful pregnancies in radiation-exposed rhesus monkeys

A strategy developed by Massachusetts General Hospital (MGH) researchers to shield the ovaries of female mammals from the damaging effects of radiation and chemotherapy has passed an important milestone. A collaborative study with investigators from Oregon Health and Sciences University (OHSU), published online in the journal Fertility and Sterility, reports that brief preexposure of the ovaries to an FDA-approved agent called FTY720 preserved the fertility of female rhesus monkeys exposed to potentially lethal doses of radiation.

23 Feb 2011

Scientist develops FMR1 genetic blood test for predicting IVF outcomes

A researcher at Albert Einstein College of Medicine of Yeshiva University has helped to develop the first genetic blood test for predicting the chances that in vitro fertilization will lead to a successful pregnancy.

13 Jan 2011

European Menopause and Andropause Society's position statements on post-reproductive health of women

Elsevier announced today the publication of four important position statements from the European Menopause and Andropause Society (EMAS) in the journal Maturitas on common management problems in the post-reproductive health of women. The statements cover the management of the menopause in the context of obesity, epilepsy, endometriosis and premature ovarian failure. Each statement has summary recommendations as a quick aid for the busy clinician.

3 Sep 2010

Diagnosis of antiovarian autoantibodies in infertile women help in approaches for assisted reproduction

Studies on the ovarian antigens and its corresponding specific antibodies have showed the relationship between the incidences of antiovarian autoantibodies and the clinical mani-festation of ovarian dysfunction and infertility in women.

4 Jun 2010

Abnormal androgen signaling in ovaries cause female infertility

Male sex hormones, such as testosterone, have well defined roles in male reproduction and prostate cancer. What may surprise many is that they also play an important role in female fertility. A new study finds that the presence and activity of male sex hormones in the ovaries helps regulate female fertility, likely by controlling follicle growth and development and preventing deterioration of follicles that contain growing eggs.

27 May 2010

Guidance for evaluating menopause-like condition in girls and young women

A comprehensive plan to help health care professionals diagnose and treat primary ovarian insufficiency-a menopause-like condition affecting girls and young women that may occur years before normal menopause is expected-has been developed by a scientist at the National Institutes of Health.

5 Feb 2009

EMD Serono launches patient registry for egg freezing

EMD Serono, Inc., an affiliate of Merck KGaA of Darmstadt, Germany, announced the launch of the Human Oocyte Preservation Experience (HOPE) Registry surrounding next week's 64th Annual Meeting of the American Society for Reproductive Medicine (ASRM).

8 Nov 2008

New insight into the menopause

Insight into why females of some species undergo menopause while others do not has proven elusive despite an understanding of the biological mechanisms behind the change.

1 Apr 2008

New research advancements in the treatment of premature ovarian failure

Scientific Director of the Meharry Center for Women's Health Research and a team of researchers from the University of Texas Medical Branch and the University of Saskatchewan have recently discovered that the gene mutation believed to be a possible cause of premature ovarian failure may be corrected when an adenovirus compensating for the mutated gene is introduced. Findings were reported in the recent issue of Molecular Human Reproduction.

15 Jan 2008

Woman has successful ovarian transplant from her sister

A woman whose ovaries were damaged by chemotherapy and radiotherapy, has received a successful ovarian transplant from her sister.

1 Aug 2007

Israeli scientists successfully transplant ovaries in sheep and trigger early embryonic development

Israeli scientists report in Human Reproduction that they have successfully transplanted whole frozen and thawed ovaries in sheep, retrieved oocytes from these ovaries and triggered them in the laboratory into early embryonic development.

26 Sep 2005

Fragile X-associated tremor/ataxia syndrome difficult to diagnose

Fragile X-associated tremor/ataxia syndrome can be difficult to diagnose and should have guidelines for diagnostic testing, according to a study in the July 26 issue of Neurology, the scientific journal of the American Academy of Neurology. A second study found chemotherapy aggravated symptoms in one woman's case.

25 Jul 2005

Tool to predict potential ovarian failure after radiation

Doctors in the United Kingdom have created a table to predict when a woman who has undergone radiation therapy as a part of cancer treatment regimen in her abdominal or pelvic area may become sterile

6 Jul 2005