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Specific mutations in FLT3 receptor can contribute to acute myeloid leukemia

Specific mutations (N676K) in the FLT3 receptor can contribute to the development of acute myeloid leukemia. The FLT3 receptor regulates cell growth, while activating gene mutations promote the uncontrolled proliferation of white blood cells. These findings were reported in the specialist journal Blood by a group of scientists from the Helmholtz Zentrum München and the Hospital of the Ludwig Maximilians University in Munich as part of a clinical research collaboration with the German Cancer Consortium.

3 Aug 2013

Researchers now have more complete picture of mTORC1 pathway that can lead to cancer, diabetes

Deciphering the body's complex molecular pathways that lead to disease when they malfunction is highly challenging. Researchers at Sanford-Burnham Medical Research Institute now have a more complete picture of one particular pathway that can lead to cancer and diabetes. In the study published by Molecular Cell, the scientists uncovered how a protein called p62 has a cascade affect in regulating cell growth in response to the presence of nutrients such as amino acids and glucose. Disrupting this chain may offer a new approach to treating disease.

2 Aug 2013

New technique accelerate tissue repair, reduce costs for chronic wound management

In a small clinical study, researchers administered a new method for treating chronic wounds using a novel ultrasound applicator that can be worn like a band-aid. The applicator delivers low-frequency, low-intensity ultrasound directly to wounds, and was found to significantly accelerate healing in five patients with venous ulcers.

2 Aug 2013

Trace substance in sugar improves muscle regeneration in mouse model with muscular dystrophy

A trace substance in caramelized sugar, when purified and given in appropriate doses, improves muscle regeneration in a mouse model of Duchenne muscular dystrophy. The findings are published today, Aug. 1, in the journal Skeletal Muscle.

2 Aug 2013

New type of chemical modification affects proteins, could provide insights into causes of cancer

Scientists at The Scripps Research Institute (TSRI) have discovered a new type of chemical modification that affects numerous proteins within mammalian cells. The modification appears to work as a regulator of important cellular processes including the metabolism of glucose.

2 Aug 2013

Study: New therapeutic approach to treat prostate cancer

A study in the Journal of Biological Chemistry identifies a new therapeutic approach to treat prostate cancer. Conducted at Cincinnati Children's Hospital Medical Center, the research shows that expression of the FoxM1 protein is essential for prostate cancer to develop in mouse models. The study appears in the journal's Aug. 2 edition.

2 Aug 2013

CHOP researchers advance stem cell studies in childhood leukemia, Diamond Blackfan anemia

First produced only in the past decade, human induced pluripotent stem cells are capable of developing into many or even all human cell types. In new research, scientists reprogrammed skin cells from patients with rare blood disorders into iPSCs, highlighting the great promise of these cells in advancing understanding of those challenging diseases-and eventually in treating them.

31 Jul 2013

Research: Lymph nodes provide correct breast cancer prognosis

After a breast cancer operation, the removed tumour is always examined, as its subtype can provide an indication of how aggressive the disease is. The patient's lymph nodes are not analysed in the same way.

29 Jul 2013

Nanofiber scaffolds regulate apoptosis, proliferation in neural stem cells by altering gene expression

The surface characteristics of nanoscaffolds made by nanotechnology are more similar to the three-dimensional topological structure of the extracellular matrix and the effects on the biological behaviors of cells and tissue repair are more beneficial.

26 Jul 2013

Researchers find that Notch signaling elevated in tumors relative to normal bone

Many cancers show inappropriate activation of a cell signaling pathway called NOTCH. In the developing body, NOTCH tells brain cells to grow and proliferate. It should be quiet in the adult body, but cancers restart NOTCH to drive their own growth, far and beyond the rate of healthy tissues.

25 Jul 2013

Mda-9/syntenin helps regulate bladder cancer growth and metastasis

Scientists from Virginia Commonwealth University Massey Cancer Center have provided evidence from preclinical experiments that a gene known as melanoma differentiation associated gene-9/syntenin (mda-9/syntenin) could be used as a therapeutic target to kill bladder cancer cells, help prevent metastasis and even be used to non-invasively diagnose the disease and monitor its progression.

25 Jul 2013

OracleBio to highlight Oncology image analysis expertise at Tumor Models conference

OracleBio, providers of high precision digital image analysis services for detailed quantification of histological marker staining within cells and tissues, is pleased to announce it will be a principal sponsor of the forthcoming Tumor Models conference to be held in Boston, MA on the 23-25th July.

24 Jul 2013

3-D hydrogel approach to study aggressive and deadly forms of brain cancer

Human glioblastoma multiforme, one of the most common, aggressive and deadly forms of brain cancer, is notoriously difficult to study. Scientists have traditionally studied cancer cells in petri dishes, which have none of the properties of the brain tissues in which these cancers grow, or in expensive animal models.

24 Jul 2013

Understanding cancer at source could improve disease prevention

A new disease is affecting developing countries, deadlier than malaria, AIDS and tuberculosis combined. With changes in lifestyles, cancer is spreading in southern countries.

23 Jul 2013

New stem cell discovery may help scientists replace damaged organs

Stem-cell researchers at UC San Francisco have found a key role for a protein called BMI1 that may help scientists direct the development of tissues to replace damaged organs in the human body.

22 Jul 2013

UCSF researchers find a way to knock down cancers caused by tumor-driving protein

UC San Francisco researchers have found a way to knock down cancers caused by a tumor-driving protein called -myc,- paving the way for patients with myc-driven cancers to enroll in clinical trials for experimental treatments.

20 Jul 2013

UCSF researchers find way to knock down cancers caused by myc protein

UC San Francisco researchers have found a way to knock down cancers caused by a tumor-driving protein called "myc," paving the way for patients with myc-driven cancers to enroll in clinical trials for experimental treatments.

19 Jul 2013

Discovery provides evidence that genetic defect responsible for Down syndrome can be suppressed

Scientists at the University of Massachusetts Medical School are the first to establish that a naturally occurring X chromosome "off switch" can be rerouted to neutralize the extra chromosome responsible for trisomy 21, also known as Down syndrome, a genetic disorder characterized by cognitive impairment.

18 Jul 2013

Researchers discover new protein that encourages ‘bad’ blood vessel growth

The discovery of a protein that encourages blood vessel growth, and especially 'bad' blood vessels - the kind that characterise diseases as diverse as cancer, age-related macular degeneration and rheumatoid arthritis - has been reported in the journal Nature.

18 Jul 2013

TAp73 protein frequently overexpressed in wide range of human tumors

They say you can pick your friends, but not your family. The same may hold true for related proteins. The protein TAp73 is a relative of the well-known, tumor-suppressor protein p53. It shares extensive common gene sequences with p53 and, as suggested by some previous studies, it may function similar to p53 to prevent tumor formation.

17 Jul 2013

Proliferation News and Research

Specific mutations in FLT3 receptor can contribute to acute myeloid leukemia

Researchers now have more complete picture of mTORC1 pathway that can lead to cancer, diabetes

New technique accelerate tissue repair, reduce costs for chronic wound management

Trace substance in sugar improves muscle regeneration in mouse model with muscular dystrophy

New type of chemical modification affects proteins, could provide insights into causes of cancer

Study: New therapeutic approach to treat prostate cancer

CHOP researchers advance stem cell studies in childhood leukemia, Diamond Blackfan anemia

Research: Lymph nodes provide correct breast cancer prognosis

Nanofiber scaffolds regulate apoptosis, proliferation in neural stem cells by altering gene expression

Researchers find that Notch signaling elevated in tumors relative to normal bone

Mda-9/syntenin helps regulate bladder cancer growth and metastasis

OracleBio to highlight Oncology image analysis expertise at Tumor Models conference

3-D hydrogel approach to study aggressive and deadly forms of brain cancer

Understanding cancer at source could improve disease prevention

New stem cell discovery may help scientists replace damaged organs

UCSF researchers find a way to knock down cancers caused by tumor-driving protein

UCSF researchers find way to knock down cancers caused by myc protein

Discovery provides evidence that genetic defect responsible for Down syndrome can be suppressed

Researchers discover new protein that encourages ‘bad’ blood vessel growth

TAp73 protein frequently overexpressed in wide range of human tumors

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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