Proliferation News and Research

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Findings may provide new insights into diabetes; suggest novel targets for drug intervention

The neuropeptide corticotropin-releasing factor (CRF) makes cameo appearances throughout the body, but its leading role is as the opening act in the stress response, jump-starting the process along the hypothalamus-pituitary-adrenal (HPA) axis. Researchers at the Salk Institute for Biological Studies have found that CRF also plays a part in the pancreas, where it increases insulin secretion and promotes the division of the insulin-producing beta cells.

22 Jan 2010

Understanding mechanism of SIRT6 activity may help treat diabetes and cancer

A study investigating how a cellular enzyme affects blood glucose levels in mice provides clues to pathways that may be involved in processes including the regulation of longevity and the proliferation of tumor cells.

22 Jan 2010

Study demonstrates BTG2 gene is crucial for neurogenesis and contextual memory function

The birth of new neurons, a process called neurogenesis, is continuously occurring in the brain, not only during development but also during adulthood within two specialized areas, the hippocampus and the subventricular zone.

21 Jan 2010

Rainbow Light Nutritional Systems converts its bottled vitamin line to sustainable EcoGuard bottles

Rainbow Light® Nutritional Systems, a leader in natural nutrition for over 25 years, is converting its entire bottled vitamin line to sustainable EcoGuard(TM) bottles. The first in the industry to be made from 100 percent recycled plastic, the innovative EcoGuard bottles are 100 percent recyclable.

21 Jan 2010

Scientists discover new mechanism that explains role of EBV in tumor growth

The Epstein-Barr virus (EBV), a virus of the herpes family, has two distinct life phases: After infecting a cell it first goes into a resting phase. Under certain circumstances the virus can become active - and then induces tumor growth or promotes its synthesis in the cell.

18 Jan 2010

HHMI: Distinct cancer-causing mutations in neighboring cells can cooperate to produce tumors

According to modern biology textbooks, a single genetic mutation is rarely enough to cause cancer. It is generally thought that cells must accumulate a series of mutations that work together to trigger tumor development.

18 Jan 2010

M. D. Anderson researchers discover mechanism that helps glioblastomas evade immune attack

Cancer-initiating cells that launch glioblastoma multiforme, the most lethal type of brain tumor, also suppress an immune system attack on the disease, scientists from The University of Texas M. D. Anderson Cancer Center report in a paper featured on the cover of the Jan. 15 issue of Clinical Cancer Research.

18 Jan 2010

New findings may yield novel therapies for chronic neurodegenerative diseases

We all have at one time or another experienced the typical signs of an infection: the fever, the listlessness, the lack of appetite. They are orchestrated by the brain in response to circulating cytokines, the signaling molecules of the immune system. But just how cytokines' reach extends beyond the almost impenetrable blood-brain barrier has been the topic of much dispute.

18 Jan 2010

Law enforcement and community activists join hands to support anti-marijuana cause

With President Obama leading the charge against legalization of marijuana in what he calls a "new era of responsibility," a cultural change is taking place in California as more and more community activists join law enforcement officers, former drug addicts and faith-based leaders in support of the anti-marijuana cause.

13 Jan 2010

Synta Pharmaceuticals presents preclinical results of STA-9090 at AACR-IASLC Joint Conference

Synta Pharmaceuticals Corp. (NASDAQ: SNTA), a biopharmaceutical company focused on discovering, developing, and commercializing small molecule drugs to treat severe medical conditions, today announced that preclinical results presented at the AACR-IASLC (American Academy of Cancer Research – International Association for the Study of Lung Cancer) Joint Conference based on work done at Synta and at the Dana-Farber Cancer Institute in Boston showed that STA-9090, a potent, synthetic inhibitor of heat shock protein 90 (Hsp90), demonstrated potent activity against 100% of all non-small cell lung cancer cell lines tested, including those with EGFR, HER2 or KRAS mutations including the EGFR T790 mutation that is present in roughly 50% of cases of erlotinib or gefitinib resistance.

13 Jan 2010

HGS reports commercialization of late-stage products for systemic lupus and chronic hepatitis C

Human Genome Sciences, Inc. today will announce its priority goals for 2010 and report on the Company’s increasing momentum toward commercialization of late-stage products for systemic lupus and chronic hepatitis C in a presentation by H. Thomas Watkins, President and Chief Executive Officer, to financial analysts and investors at the 28th Annual JPMorgan Healthcare Conference in San Francisco.

12 Jan 2010

Biocomposites' geneX ds, the resorbable bone graft material with negative surface charge launched

Biocomposites, the pioneers in synthetic bone graft materials have launched geneX ds, a dual syringe mixing and minimally invasive delivery system containing geneX, the unique resorbable bone graft material with a negative surface charge.

12 Jan 2010

Study analyses physiological parameters of athletes

The maximum time an athlete is able to continue climbing to exhaustion may be the only determinant of his/her performance. A new European study, led by researchers from the University of Granada, the objective of which is to help trainers and climbers design training programmes for this type of sport, shows this to be the case.

9 Jan 2010

SeraCare Life Sciences launches new products to aid discovery and development of drugs and diagnostics

SeraCare Life Sciences, Inc. announced today that the Company has added five new, differentiated products to its portfolio to meet the needs of SeraCare’s growing customer base in the life sciences industry.

9 Jan 2010

Breakthrough findings could lead to new treatments for prostate, brain and skin cancers

Researchers at the Lady Davis Institute for Medical Research of the Jewish General Hospital and McGill University in Montreal have discovered a previously unsuspected link between two different genetic pathways which suppress the growth of cancer tumours.

8 Jan 2010

Protein complex proves valuable for changing cell fate

The DNA contained within each of our cells is exactly the same, yet different types of cells - skin cells, heart cells, brain cells - perform very different functions. The ultimate fate of these cells is encoded not just in the DNA, but in a specific pattern of chemical modifications that overlay the DNA structure.

7 Jan 2010

Eisai acquires AkaRx for approximately $255 million

Eisai Inc. (Headquarters: Woodcliff Lake, New Jersey, Chairman and CEO: Hajime Shimizu, "Eisai") today announces the successful completion of its acquisition of the biopharmaceutical company, AkaRx, Inc. (Headquarters: Bridgewater, New Jersey, CEO: Robert E. Desjardins), for approximately $255 million.

6 Jan 2010

CSHL scientist discovers how bookmarking protein triggers leukemia

Each cell inherits genes from its parent as well as epigenetic information - what amounts to an instruction manual that specifies which genes should be activated or "expressed," when and to what level.

6 Jan 2010

OncoMed Pharmaceuticals and Fluidigm announce new initiative to analyze tumor cell heterogeneity

OncoMed Pharmaceuticals, Inc. and Fluidigm Corporation today announced a new initiative to apply Fluidigm's unique microfluidic tools to the analysis of tumor cell heterogeneity, including cancer stem cells.

6 Jan 2010

Opinions: U.S. medical emergency response; micronutrients; rotavirus vaccine; antibiotic development

"[D]espite the tireless efforts of public health and health-care workers, America's experience with H1N1 shows that the nation is not prepared to deal with a flu pandemic," former Democratic Senator Bob Graham and former Republican Senator Jim Talent write in Washington Post opinion piece that examines U.S. preparedness for medical emergencies. The writers chaired the Commission on the Prevention of Weapons of Mass Destruction Proliferation and Terrorism.

6 Jan 2010

Proliferation News and Research

Findings may provide new insights into diabetes; suggest novel targets for drug intervention

Understanding mechanism of SIRT6 activity may help treat diabetes and cancer

Study demonstrates BTG2 gene is crucial for neurogenesis and contextual memory function

Rainbow Light Nutritional Systems converts its bottled vitamin line to sustainable EcoGuard bottles

Scientists discover new mechanism that explains role of EBV in tumor growth

HHMI: Distinct cancer-causing mutations in neighboring cells can cooperate to produce tumors

M. D. Anderson researchers discover mechanism that helps glioblastomas evade immune attack

New findings may yield novel therapies for chronic neurodegenerative diseases

Law enforcement and community activists join hands to support anti-marijuana cause

Synta Pharmaceuticals presents preclinical results of STA-9090 at AACR-IASLC Joint Conference

HGS reports commercialization of late-stage products for systemic lupus and chronic hepatitis C

Biocomposites' geneX ds, the resorbable bone graft material with negative surface charge launched

Study analyses physiological parameters of athletes

SeraCare Life Sciences launches new products to aid discovery and development of drugs and diagnostics

Breakthrough findings could lead to new treatments for prostate, brain and skin cancers

Protein complex proves valuable for changing cell fate

Eisai acquires AkaRx for approximately $255 million

CSHL scientist discovers how bookmarking protein triggers leukemia

OncoMed Pharmaceuticals and Fluidigm announce new initiative to analyze tumor cell heterogeneity

Opinions: U.S. medical emergency response; micronutrients; rotavirus vaccine; antibiotic development

Achieving and maintaining ISO 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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