Proliferation News and Research

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Gefitinib (Iressa) could reduce the size of breast cancer tumours

Giving women with early breast cancer a drug called gefitinib (Iressa) before surgery could reduce the size of their tumours, suggests a randomised trial published online today by The Lancet Oncology.

17 May 2005

Drugs that block the enzyme Odc prevent the onset of cancers

The drug DFMO prevents cancer in laboratory models of lymphoma but fails to kill existing cancerous cells that have lost the ability to self-destruct, according to investigators at St. Jude Children's Research Hospital.

16 May 2005

Intralesional immunotherapy for common warts is effective and safe

Injection of skin test antigens (preparations used in skin tests for immunity) into warts appears to stimulate the immune system and successfully treat the injected wart and also helps to treat distant non-injected warts, according to a study in the May issue of Archives of Dermatology.

16 May 2005

Critical lock and key mechanism found for the assembly of tumor blood vessels

A critical lock and key mechanism that allows the final step in the completion of new blood vessel formation has been identified by a University of California, San Diego (UCSD) School of Medicine team in research that promises to lead to a new way to halt tumor growth by cutting off the tumor blood supply.

3 May 2005

Research provides new insight into how individual genes control regeneration

Although they may look small and unassuming, planarian worms are famous in the scientific world for their extraordinary ability to regenerate body parts after injury. Even a small piece cut off a planarian can reorganize and regenerate to form a whole new worm.

2 May 2005

Specific genes play key role in the of regulation of human-blood stem cells

This work is the first to validate gene expression analysis in human stem cells with functional experiments. The findings also suggest that changes in the expression of genes associated with universal cell signaling pathways can have a substantial impact on human stem cell behavior.

2 May 2005

Symptoms of concussion may increase when the outcome of a lawsuit is at stake

The condition known as “postconcussional syndrome” is difficult to define medically but is generally defined as a string of cognitive, physical or behavioral losses that occur after a head injury.

1 May 2005

P12 protein influences key cell-signaling pathway

New research shows that a protein produced by a cancer-causing virus influences a key signaling pathway in the immune cells that the virus infects. This stimulates the cells to divide, helping the virus spread through the body.

26 Apr 2005

Breast cancer gene may play a major role in the recurrence of prostate cancer

A gene associated with breast cancer also may play a major role in the recurrence of prostate cancer, according to new research from the University of North Carolina at Chapel Hill School of Medicine and UNC Lineberger Comprehensive Cancer Center.

20 Apr 2005

Researchers determine structure of binding site of colon-cancer drug Erbitux and its protein target

Researchers at the University of Pennsylvania School of Medicine have determined the precise molecular details of how Erbitux, a recently approved colorectal cancer drug, binds to its target on cancer cells. Knowing this chemical configuration will lead to better drug design for this family of cancer medications.

19 Apr 2005

Researchers discover mechanism by which tumours support their own growth

In a recent issue of the American Journal of Pathology, the Bremen researchers report their findings on a signalling molecule called "High Mobility Group Protein B1" (HMGB1). As a signal sent by tumour cells HMGB1 proteins induce sprouting of blood vessels that supply tumours with oxygen, thus promoting tumour growth.

11 Apr 2005

Ephrins may influence learning

A Burnham Institute study has found that one of the cell's largest families of signaling molecules, called ephrins, which are known to regulate the development of nerve cells, also controls nerve cells' ability to engulf critical chemicals and proteins for learning and memory.

11 Apr 2005

Yeast discovery provides new insights into familial dysautonomia

A discovery in yeast that has important implications for finding a cure for a devastating disease of nerve cell failures -- called familial dysautonomia (FD) -- has been made by Cornell University researchers.

6 Apr 2005

Mutations in the HFE gene directly associated with chronic joint disease

Mutations in the HFE gene, which is involved in iron regulation, seem to be directly associated with chronic joint disease (or haemophilic arthropathy) among haemophilic patients, claim a team of Portuguese scientists in the April issue of the journal Blood.

4 Apr 2005

Researchers show role of Epstein-Barr virus in cancer

Researchers at the University of Toronto have mapped the molecular details that show how a viral protein coded in the Epstein-Barr virus immortalizes cells and causes them to continuously grow, thereby predisposing people to certain types of cancer.

3 Apr 2005

Statins, other cholesterol-depleting agents, may disrupt hypertension from developing

Cholesterol-lowering agents, such as the widely-prescribed statin drugs, and cholesterol-blocking agents may prove to be “novel therapeutic agents to modify cellular calcium that contributes to the development of pulmonary hypertension,” according Hemal H. Patel who lead a multidisciplinary team of researchers at the University of California, San Diego (UCSD).

3 Apr 2005

Cells that might be able to suppres cat allergies

In a paper in this month's premier open-access medical journal PLoS Medicine, Mark Larche and colleagues from Imperial College London describe a subset of cells that might be able to suppress cells that cause cat allergy.

29 Mar 2005

Grapes inhibit cancer growth

Components in grapes, including some newly identified ones, work together to dramatically inhibit an enzyme crucial to the proliferation of cancer cells, say scientists at the University of Illinois at Urbana-Champaign.

29 Mar 2005

Three different leukemias are all caused by mutations that alter a specific enzyme controlling blood cell proliferation

Identifying the genetic malfunction that causes these disorders raises the hope that researchers may be able to devise a targeted therapy, just as they have done for chronic myelogenous leukemia (CML), which is presently treated with Gleevec. The three leukemias that share a common genetic cause are polycythemia vera (PV), essential thrombocythemia (ET) and myeloid metaplasia with myelofibrosis (MMM).

28 Mar 2005

Strawberries destroy cancer cells

Researchers specializing in the health benefits of plant compounds have shown that quercetin, a phytonutrient found in abundance in strawberries and other fruits, can induce programmed self-destruction of human cancer cells.

23 Mar 2005