Proliferation News and Research

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Celecoxib may regulate a cell's use of estrogen - might help explain the drug's anticancer properties

Six months of treatment with celecoxib (Celebrex) in women at risk of developing breast cancer results in the reduction of estrogen receptor expression in breast cells, a research team at The University of Texas M. D. Anderson Cancer Center has found.

13 Dec 2004

Resveratrol antioxidant found in red wine may benefit heart tissue

New research on rat heart cells suggests that a well-known antioxidant found in red wine, called resveratrol, may benefit heart tissue by limiting the effects of a condition called cardiac fibrosis.

8 Dec 2004

Study shows long-term benefits for chronic myeloid leukemia patients receiving therapy with imatinib

CHU in Poitiers, France, yesterday announced results of a study showing that newly diagnosed patients with a certain form of leukemia who are treated early with imatinib are more likely to achieve complete cytogenetic responses (the elimination of leukemic cells, a major goal of therapy) and have improved long-term outcomes.

6 Dec 2004

Positive results from phase 2 trial of Telintra, drug candidate in myelodysplastic syndrome

Telik, Inc. reported positive interim data from a Phase 2 trial of its Telintra (TLK199) drug candidate in myelodysplastic syndrome (MDS). The data were reported in two presentations at the annual meeting of the American Society of Hematology in San Diego.

5 Dec 2004

Single dose phase I data on CG53135 for the prevention of oral mucositis

CuraGen Corporation has announced results presented from a Phase I clinical trial with CG53135 for the prevention of oral mucositis (OM) in patients receiving high dose chemotherapy (HDCT) followed by autologous hematopoietic stem cell transplantation (AHSCT) at the ASH 46th Annual Meeting in San Diego, CA.

5 Dec 2004

Discovery of a new cancer gene, which, when damaged, may promote prostate cancer

Together with an international research team, researchers from VTT Technical Research Centre of Finland have developed an effective method for the screening and identification of genes that under normal conditions suppress cancer growth.

24 Nov 2004

New mechanism that contributes to the development of some breast and ovarian cancers

Researchers at Mount Sinai School of Medicine have discovered a new mechanism of activation of a pathway known to be implicated in many cancers.

23 Nov 2004

Overexpression of a protein called Down Syndrome Critical Region 1 (DSCR-1) reduces tumor growth

Scientists have found that overexpression of a protein called Down Syndrome Critical Region 1 (DSCR-1) blocks the formation of new blood vessels and thus reduces tumor growth. Therapeutics based on this finding may potentially lead to new cancer treatments.

19 Nov 2004

Lorus Therapeutics allowed Canadian patent to protect anticancer drugs

Lorus Therapeutics today announced that its wholly owned subsidiary, GeneSense Technologies Inc., has been allowed a patent by the Canadian Patent Office entitled "Antitumor Antisense Sequences Directed Against R1 and R2 Components of Ribonucleotide Reductase."

10 Nov 2004

Discovery of new gene that protects against lung cancer

Cancer Research UK scientists have discovered a new gene that protects against lung cancer, according to a study published in the journal PNAS.

9 Nov 2004

After stopping drinking, the brain grows back - significant implications for treatment of alcoholism during recovery

University of North Carolina at Chapel Hill scientists have reported - for the first time - a burst in new brain cell development during abstinence from chronic alcohol consumption.

8 Nov 2004

Celebrex may one day be used to prevent and even treat breast tumors

The anti-inflammatory drug Celebrex, or celecoxib, reduces tumor mass by encouraging cell death and discouraging both cell proliferation and the sprouting of new blood vessels that feed growing tumors, according to a study reported in the November issue of Molecular Cancer Research.

5 Nov 2004

STAT3 protein could lead to new ways to prevent skin cancer

Scientists at The University of Texas M. D. Anderson Cancer Center have identified a protein that serves as a master regulator of skin cancer - a finding that could lead to new ways to prevent skin cancer before it starts.

4 Nov 2004

Protein important to nerve development serves the dual purpose of stimulating the growth of blood vessels

The discovery opens the possibility that blood vessel growth (angiogenesis) one day may be induced, or stymied, for therapeutic use against heart disease, cancer, and other illnesses, according to Dean Y. Li, M.D., Ph.D., associate professor of internal medicine in the U of U School of Medicine's Division of Cardiology.

1 Nov 2004

Fatbuster drug targets obesity

A new drug to combat obesity at a cellular level is in the sights of a University of Queensland scientist.

25 Oct 2004

High levels of a protein called LRP6 can make cancer cells more aggressive

The protein's ability to enhance tumor development suggests that the gene that codes for LRP6 is an oncogene--a gene that contributes to tumor development when overactivated.

25 Oct 2004

Potential new protein marker for prognosis of breast and ovarian cancer

The researchers matched tumor samples to outcomes in about 100 patients diagnosed with either breast or ovarian cancer and found that a low level of Rab25 protein on a patient's cancer sample was associated with a better clinical outcome in both cancer types.

24 Oct 2004

Common antibacterial and antifungal ingredient used in tooth paste may protect against skin cancer

According to new studies, sanguinarine was shown to enhance production of proteins that induce cell death, or apoptosis, in cells damaged by ultraviolet-B (UVB) radiation.

21 Oct 2004

Study will evaluate arsenic exposure from the environment and its potential carcinogenic effects

The National Cancer Institute has awarded the Arizona Cancer Center at the University of Arizona Health Sciences Center a three-year grant to evaluate associations between elevated arsenic exposure and cancer incidence in Arizona and Mexico.

19 Oct 2004

New genetic mechanism has been identified linking diet to breast cancer

Experiments carried out by scientists at the Universitat Autònoma de Barcelona on experimentally induced breast cancer tumours in laboratory rats show that an excess of certain fats in the diet, commonly known as omega-6, accelerates breast cancer, increasing the malignancy of the disease.

18 Oct 2004