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Chimeric reference standards for validating controls in SARS-CoV-2 tests

A preliminary study by researchers from the Garvan Institute of Medical Research and the University of New South Wales and published on the preprint server bioRxiv in June 2020 reports the use of chimeric design to produced reference standards for diagnostic tests. This could allow a highly flexible approach to the development of different genetic features in the same test, even for organisms that are not directly related.

15 Jun 2020

Females mount stronger T-cell response to SARS-CoV-2

A new study published on the preprint server medRxiv in June 2020 shows that immune cells, antibody levels, cytokine levels, and viral loads contribute to the sex difference seen in response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

10 Jun 2020

RNA interference machinery influences epithelial cell biology

Epithelial cells are held together and connected by several different types of structures that form cell-cell contacts.

9 May 2020

Study provides more insight into the initiation and progression of human cancers

Volume 11, Issue 18 of @Oncotarget Clinical implications of chromatin accessibility assessed by ATAC-seq profiling in human cancers especially in a large patient cohort is largely unknown.

6 May 2020

Russian scientists create humanized mice to test drugs and vaccines for COVID-19

Following the recent Coronavirus outbreak, almost three million people have been infected worldwide, whereas the death toll has already passed the 200,000 mark, according to official reports.

5 May 2020

Transposable elements play key role in genetic expression and evolution, study shows

Until recently, little was known about how transposable elements contribute to gene regulation. These are little pieces of DNA that can replicate themselves and spread out in the genome.

15 Apr 2020

Researchers pinpoint genetic variation responsible for development of IBD

Researchers at Children's Hospital of Philadelphia have pinpointed a genetic variation responsible for driving the development of inflammatory bowel disease.

9 Apr 2020

Roscovitine enhances nuclear enrichment of traditionally cytoplasmic signaling molecules

Oncotarget Volume 11, Issue 12 reported that using the HL-60 human non-APL AML model where ATRA causes nuclear enrichment of c-Raf that drives differentiation/G0-arrest, the research team now observe that roscovitine enhanced nuclear enrichment of certain traditionally cytoplasmic signaling molecules and enhanced differentiation and cell cycle arrest.

26 Mar 2020

Combination produces more proliferative, enduring central memory T cells for cellular therapy

Treating T cells harvested from a patient with a combination of an epigenetic drug and a cytokine while expanding the cells in the lab re-programs them into a stronger T cell type that persists longer than its comrades, researchers at The University of Texas MD Anderson Cancer Center report in Cancer Immunology Research, a journal of the American Association for Cancer Research.

25 Mar 2020

3D chromatin landscapes in T cell acute lymphoblastic leukemia important beyond DNA code changes

Children with aggressive blood cancers have differences -- not just in the DNA code of their blood cells -- but also in the heavily twisted protein superstructure that controls access to genes.

23 Mar 2020

Changes in 3D genetic structure equally important as DNA code mutations in childhood leukemia

A study found that children with aggressive blood cancers have different superstructures of the proteins that control gene access.

23 Mar 2020

Why is the tobacco industry supporting wider access to medical cannabis?

A new study published in the BMJ reveals disturbing connections between organizations and groups that are lobbying for broader access to medical cannabis and those who are fighting for the legalization of recreational cannabis. This raises questions as to the reasons behind the industry’s support for measures that will make it easier for patients to gain access to medical cannabis – is it because of the knowledge that by so doing, they will also be able to market the drug for recreational use in the UK?

18 Mar 2020

How do cells protect themselves from viruses?

Amid the coronavirus outbreak that is wreaking havoc across the globe, it is essential to know how the cells of the body evade infection from viruses. A team of scientists has explained the mechanism that takes place in case a virus penetrates the body.

4 Mar 2020

Potential genetic test for earlier Alzheimer's diagnosis

A new study published in the journal Epigenetics in February 2020 reports that changes in the methylation status of the Presenilin 1 (PSEN1) gene could help diagnose Alzheimer's disease (AD) earlier. This study shows for the first time that methylation of this gene is a common feature in AD.

1 Mar 2020

Study identifies novel anti-aging targets

A recent study published in Nature has reported two conserved epigenetic regulators as novel anti-aging targets.

26 Feb 2020

Small molecules may open the door to new therapies for Duchenne muscular dystrophy

Researchers identified a group of small molecules that may open the door to developing new therapies for Duchenne muscular dystrophy, an as-yet-uncured disease that results in devastating muscle weakening and loss.

24 Feb 2020

New study expands the knowledge on tumor-suppressor role of HERC proteins

The RAF protein could be a therapeutical target to treat the tumor growth in regulated pathways by the p38 protein, according to a new study published in the journal Scientific Reports by a team of experts of the Faculty of Medicine and Health Sciences of the University of Barcelona and the Bellvitge Institute for Biomedical Research.

20 Feb 2020

Stress in kids could have long term genetic consequences finds study

Researchers have found that being separated from parents at a young age could lead to a rise in stress hormones, which could have direct consequences on altering the genetic makeup of the child, which can then be passed on to the future generations. The study titled, "Childcare outside the family for the under-threes: cause for concern?" was published in the latest issue of the Journal of the Royal Society of Medicine.

16 Feb 2020

Minigenes produced by CRISPR combat liver disease in mice

A new gene-editing technique based on CRISPR was used to successfully avoid the development of a liver disease that can be caused by hundreds of mutations, as well as to ease the symptoms in mice. This proof-of-concept study was published online in the journal Science Advances in February 2020.

12 Feb 2020

Analyzing cancer-specific alterations found in tumor's RNA

Researchers at EMBL-EBI were among the leaders of a large international consortium that carried out a joint analysis of data from over 1000 donors of more than 25 cancer types, studying data on their whole genomes along with tumor transcriptome data, which indicates the genes that are active within a tumor.

6 Feb 2020