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Amplification of venous thromboembolism risk by COVID-19 among malignancy patients

In a new study, researchers reported the mechanisms involved in COVID-19 coagulopathy and the significance of SARS-CoV-2 infections for cancer patients concerning outcomes, thromboembolic complication risks, and consequences of management strategies.

14 Oct 2022

Study uncovers molecular changes in the brain’s blood vessels caused by Alzheimer’s susceptibility gene

Recent breakthroughs have revealed a great deal about Alzheimer's disease, but researchers have yet to paint a complete picture of how genetic risk for the illness causes the brain damage that ultimately leads to memory loss and cognitive decline.

30 Aug 2022

How does COVID-19 increase clotting risk?

An in-depth review article describing coronavirus disease 2019 (COVID-19)-related coagulopathy has recently been published in the journal Nature Reviews Immunology.

11 Aug 2022

Preclinical study unlocks the promise of CAR T-cell therapy for treatment of solid tumors

Scientists at St. Jude Children's Research Hospital identified a molecular mechanism that in a preclinical study unlocked the promise of CAR T–cell therapy for treatment of solid tumors.

22 Jun 2022

USC scientists receive more than $16 million to study the role of blood vessel dysfunction in Alzheimer’s disease

The National Institute on Aging, a division of the National Institutes of Health, awarded Berislav Zlokovic, MD, PhD, director of the Zilkha Neurogenetic Institute, and Arthur W. Toga, PhD, director of the USC Mark and Mary Stevens Neuroimaging and Informatics Institute (Stevens INI), $16.1 million to continue research on the role that blood vessel dysfunction plays in the development of dementia and Alzheimer's disease.

7 Jun 2022

Researchers discover how one type of T cell creates functionally distinct, but genetically identical daughter cells

Scientists at St. Jude Children's Research Hospital have solved an immunology puzzle. A CD8+ T cell can have two functionally distinct daughter cells after it divides, despite the cells being genetically identical.

20 May 2022

Scientists discover how SARS-CoV-2 activates platelets

In a recent study published in the Blood Advances journal, the researchers assessed the impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on platelet activation.

25 Apr 2022

Potential new diagnostic marker for ulcerative colitis discovered

An international research collaboration has discovered a potential new diagnostic marker for ulcerative colitis in a trans-ethnic analysis of Japanese and white patients.

10 Feb 2022

Drugs derived from activated protein C may limit ischemia and reperfusion injury, study suggests

A University of South Florida Health preclinical study offers molecular insight into how activated protein C (APC) may improve aging patients' tolerance to reperfusion injury – a potentially adverse effect of treatment for ischemic heart disease.

31 Jan 2022

Researchers identify genetic cause of rare interstitial lung disease in a young child

New research from Washington University School of Medicine in St. Louis has solved the medical mystery of why a 2-year-old child — seemingly healthy at birth — succumbed to an undiagnosed, rare illness.

31 Jan 2022

Effect of mutations on SARS-CoV-2 E protein interactions with cell junctions

In a recent study, ten human PDZ-containing proteins showed significant interactions with the SARS-CoV-2 E protein in a PBM-dependent manner.

12 Dec 2021

Fast-tracked human stroke drug may also be a safe and powerful defense against dementia

A human stroke drug, fast-tracked by the Food and Drug Administration and soon entering Phase 3 clinical trials, shows intriguing signs that it might also be a safe and powerful defense against Alzheimer's and other forms of dementia.

1 Dec 2021

The influence of COVID-19 on platelet activation and aggregation

In a paper recently uploaded to the bioRxiv* preprint server, humanized ACE2 mice are infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and platelets are subsequently isolated from the blood for quantitative proteomic analysis.

26 Aug 2021

Immunomodulatory therapies for nephrological autoimmune diseases may help treat severe COVID-19

Various viruses and bacteria have long been known to cause autoimmune diseases where there is such a predisposition. This phenomenon also seems to play a major role in SARS-CoV-2, especially in severe courses.

8 Jun 2021

Antithrombotic endothelial dysfunction is prevented by Tie2 activation in severe COVID-19

Researchers from the US recently assessed if severe COVID-19 is linked to procoagulant dysfunction of the endothelium and changes in the Tie2-angiopoietin axis. They assessed circulating endothelial markers in a study cohort of 98 patients with mild, moderate, or severe COVID-19. This study is published on the medRxiv* preprint server.

19 May 2021

Mechano-immunological response to SARS-CoV-2

In a recent study, researchers demonstrated a human organ-on-a-chip (Organ Chip) microfluidic model of the lung alveolus (Alveolus Chip) - that recapitulates the human alveolar-capillary interface with an air-liquid interface (ALI) and vascular fluid flow to understand the local triggers in the lung in vitro.

5 May 2021

Protein C News and Research

Amplification of venous thromboembolism risk by COVID-19 among malignancy patients

Study uncovers molecular changes in the brain’s blood vessels caused by Alzheimer’s susceptibility gene

How does COVID-19 increase clotting risk?

Preclinical study unlocks the promise of CAR T-cell therapy for treatment of solid tumors

USC scientists receive more than $16 million to study the role of blood vessel dysfunction in Alzheimer’s disease

Researchers discover how one type of T cell creates functionally distinct, but genetically identical daughter cells

Scientists discover how SARS-CoV-2 activates platelets

Potential new diagnostic marker for ulcerative colitis discovered

Drugs derived from activated protein C may limit ischemia and reperfusion injury, study suggests

Researchers identify genetic cause of rare interstitial lung disease in a young child

Effect of mutations on SARS-CoV-2 E protein interactions with cell junctions

Fast-tracked human stroke drug may also be a safe and powerful defense against dementia

The influence of COVID-19 on platelet activation and aggregation

Immunomodulatory therapies for nephrological autoimmune diseases may help treat severe COVID-19

Antithrombotic endothelial dysfunction is prevented by Tie2 activation in severe COVID-19

Mechano-immunological response to SARS-CoV-2

Angiopoietin-2 is a crucial determinant of COVID-19 prognosis, study finds

Study may provide the basis for better diagnostic, therapeutic approaches to blood diseases

Evidence of SARS-CoV-2 placental infection in mild COVID-19

Anticardiolipin antibodies and COVID-19

Hasret Altan-Martin

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