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Single CRISPR treatment can safely and stably correct genetic disease

Researchers at Duke University have shown that a single systemic treatment using CRISPR genome editing technology can safely and stably correct a genetic disease -- Duchenne muscular dystrophy (DMD) -- for more than a year in mice, despite observed immune responses and alternative gene editing outcomes.

18 Feb 2019

Study identifies protein regulator that induces Th17 cells to cause multiple sclerosis

Inflammatory and autoimmune diseases such as psoriasis, rheumatoid arthritis, and multiple sclerosis (MS) are a major healthcare burden worldwide and are life-altering conditions for afflicted patients.

14 Feb 2019

New PET imaging agent may help measure efficacy or failure of hormone therapy for breast cancer

Physicians may soon have a new way to measure the efficacy or failure of hormone therapy for breast cancer patients, according to new research published in the February issue of The Journal of Nuclear Medicine.

12 Feb 2019

Exercise-induced muscle changes could help boost mood in older adults, study suggests

New research suggests that exercise-induced muscle changes could help boost mood in older adults. The study is published ahead of print in the American Journal of Physiology--Cell Physiology.

31 Jan 2019

Researchers discover immune regulator that appears to dictate glioblastoma

Researchers at The University of Texas MD Anderson Cancer Center have discovered an immune regulator that appears to dictate glioblastoma progression by shutting down immune surveillance, indicating a potential new area of therapeutic investigation.

28 Jan 2019

Researchers find how GREB1 gene promotes resistance to prostate cancer treatments

Researchers have discovered how a gene involved in regulating hormone receptors may contribute to drug resistance in some prostate cancer patients.

16 Jan 2019

Study shows how specific mutations in SYNE1 gene may increase bipolar disorder risk

A new study by researchers at The Picower Institute for Learning and Memory at MIT finds that the protein CPG2 is significantly less abundant in the brains of people with bipolar disorder and shows how specific mutations in the SYNE1 gene that encodes the protein undermine its expression and its function in neurons.

9 Jan 2019

Study of rare uterine sarcoma reveals clinically relevant molecular subtypes

Undifferentiated uterine sarcoma is a very rare but extremely aggressive cancer type. It can be divided into four groups with different characteristics of clinical importance - a new study at Karolinska Institutet reveals.

7 Jan 2019

Review of recent advances in label-free quantification in cancer proteomics

In recent years, proteomics research has become a popular method for characterizing the functional proteins driving the transformation of malignancy, tracing the large-scale protein alterations induced by anti-cancer drug, as well as discovering the innovative targets and first-in-class drugs for oncologic disorders.

28 Dec 2018

Novel insight on inflammatory regulation could pave way for effective pain therapies

A novel way in which the inflammatory response to pain is regulated has been described in the open-access journal eLife.

19 Dec 2018

CWRU researcher secures $14.6 million funding for genetic study into Alzheimer's disease

Alzheimer's disease symptoms, such as memory loss or cognitive decline, can present in different ways among people with diverse ethnic backgrounds. Researchers know that a complex mix of social, behavioral, and genetic variables can impact the onset and progression of this disease.

6 Dec 2018

Scientists focus on epigenetics to identify factors involved in Hispanic childhood obesity

Are there changes that affect genes and fuel a person's propensity to develop obesity? That's a question under study at Texas Biomedical Research Institute.

27 Nov 2018

Photographic aging clock uses advances in Artificial Intelligence to predict human age

There are many factors that influence the aging process. Unlocking these factors can lead to valuable insights into what impacts the condition and health of the human body and reveal how to minimize these impacts.

26 Nov 2018

Scientists identify novel target for neuron regeneration, functional recovery in spinal cord injury

Restoring the ability to walk following spinal cord injury requires neurons in the brain to reestablish communication pathways with neurons in the spinal cord.

20 Nov 2018

Game-Changers in Western Blotting and Protein Analysis

An interview with Ramya Prabakaran & Melody Chang from GenScript, discussing the development of automated systems that improve outcomes for western blotting.

From GenScript 16 Nov 2018

Small populations of normal T cells could modify disease severity in patients with XLP1

Human SH2D1A mutations resulting in X-linked lymphoproliferative syndrome type 1 are associated with a unique susceptibility to the Epstein-Barr virus, which may lead to fatal infectious mononucleosis.

9 Nov 2018

Ischemia-induced stem cells can be promising candidates for CNS injury therapeutics

Researchers have performed a careful comparison between locally generated, ischemia-induced, multipotent stem cells and bone marrow-derived mesenchymal stem cells in an effort to determine which cell type has greater central nervous system repair capacity.

26 Oct 2018

Bioengineering scientists propose new paradigm for research into cardiovascular diseases

Thrombosis-on-a-chip, vasculature-on-a-chip and engineered models of human cardiac fibrosis are just a few of the new technologies revolutionizing research into human cardiovascular disease--a condition responsible for 17 million deaths per annum globally.

25 Oct 2018

Findings offer new insight into early changes that occur during AD pathology

Alzheimer's disease (AD) is the most common form of dementia, involving memory loss and a reduction in cognitive abilities.

12 Oct 2018

Low levels of cellular copper may make fat cells fatter

In studies of mouse cells, Johns Hopkins researchers have found that low levels of cellular copper appear to make fat cells fatter by altering how cells process their main metabolic fuels, such as fat and sugar.

11 Oct 2018