Protein Expression News and Research

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Protein Oct-6 is not a biological marker for schizophrenia

The protein Oct-6 is not a biological marker for schizophrenia. The results of a study published today in the open access journal BMC Psychiatry contradict previous findings and show that Oct-6, a protein involved in neurodevelopment, is normally expressed in the adult brain and cannot be used to identify patients with schizophrenia.

23 Oct 2005

100% efficacy for cervical cancer vaccine

Final-stage clinical trials of a cervical cancer vaccine developed by University of Queensland (UQ) scientists, have shown the drug to be 100 per cent effective.

10 Oct 2005

New role for the blood protein serum amyloid P in the body's response to medical materials

Using a technique called proteomics, the researchers identified many of the blood proteins that stick (adsorb) to the surfaces of medical devices. Blood proteins that adsorb to the surfaces of materials unfold and can be recognized by the body, which then mounts a response against the device.

5 Oct 2005

Possibility of tailored treatments for addiction based on how a person's genes behave

Scientists have learned how a genetic variation long suspected in making some people susceptible to alcoholism and narcotic drug addiction actually does so.

27 Sep 2005

Calcium fights prostate cancer

Calcium, more familiar in its role as one of the building blocks of the body, is being enlisted as a tool in the fight against prostate cancer.

15 Aug 2005

Decreased breast cancer survival associated with high TRAIL-R2 expression

High expression of TRAIL-R2, a cell surface receptor that triggers cell death, has been shown to be associated with a decrease the survival rates of breast cancer patients according to a study published by Yale Cancer Center researchers in Clinical Cancer Research.

25 Jul 2005

Researchers have pinpointed specific gene and protein over-production in metastatic melanoma

Gene amplification is a process that often happens in cancer cells when the normal DNA replication process is altered, causing many copies of the gene to be produced instead of a single copy of a region of a chromosome.

12 Jul 2005

OHSU scientists say low FOXP3 means fewer disease-fighting cells, but new drug may help multiple sclerosis

Oregon Health & Science University researchers have measured genetic changes reflecting a drop in the body's ability to suppress inflammatory cells that attack nerve fibers and promote progression of multiple sclerosis.

27 Jun 2005

Expression profiles and functional analyses of Wnt-related genes in human joint disorders

The cellular signaling protein Wnt, which is involved in embryonic development and cancer, contributes to disease progression of both rheumatoid arthritis and osteoarthritis.

26 Jun 2005

Researchers have isolated two biomarkers for interstitial cystitis (IC)

The discovery of these biomarkers could lead to a definitive test for IC and have the potential to lead to new therapies. Results of two studies are being presented today at the annual meeting of the American Urological Association (AUA) in San Antonio, and are published in abstracts 69 and 80 of the AUA proceedings.

22 May 2005

Researchers identify new areas of gene regulation

Researcher Kangling Zhang at the University of California, Riverside is part of a team that has discovered a new way that yeast governs genetic expression and repression, a finding that could be repeated in cells of other organisms.

8 May 2005

Study identifies possible marker for efficacy of gefitinib in lung cancer patients

Patients with advanced non–small-cell lung cancer (NSCLC) whose tumor cells contain extra copies of the epidermal growth factor receptor (EGFR) gene may be more likely to respond to the drug gefitinib (Iressa), and this high gene copy number may be an effective predictor of gefitinib efficacy, according to a new study in the May 4 issue of the Journal of the National Cancer Institute.

3 May 2005

Revised Bethesda guidelines effective at identifying patients at risk of colorectal cancer

The revised Bethesda guidelines, used for screening patients for a type of hereditary colorectal cancer, are effective for determining which patients should undergo further genetic testing, according to a study in the April 27 issue of JAMA.

26 Apr 2005

Vegetables such as broccoli and spices like red chili pepper, may provide a cancer-fighting benefit

Two new studies suggest that vegetables such as broccoli and spices like red chili pepper, may provide a cancer-fighting benefit by slowing or preventing the growth of cancerous tumor cells. The findings, being presented at the annual meeting of the American Association for Cancer Research held April 16 to 20 at the Anaheim Convention Center in Anaheim, Calif., looked at the effect of these dietary agents on cancers that have extremely poor prognoses despite advances in surgery and other therapies.

19 Apr 2005

Groundbreaking results for the potential treatment of Huntington's Disease

Sirna Therapeutics announced today that its collaborator at the University of Iowa, Dr. Beverly Davidson, published groundbreaking results for the potential treatment of Huntington's Disease (HD).

12 Apr 2005

Obesity may hinder body's ability to control influenza infection

Obesity apparently reduces laboratory mice’s ability to turn on elements of their immune systems needed for controlling influenza infection, a new University of North Carolina at Chapel Hill School of Medicine study shows.

4 Apr 2005

Step toward a potential treatment for Huntington's disease

Researchers at the University of Iowa Roy J. and Lucille A. Carver College of Medicine have taken another step toward a potential treatment for Huntington's disease (HD). Using an approach called RNA interference (RNAi), the scientists reduced levels of the disease-causing HD protein in mice and significantly improved the movement and neurological abnormalities normally associated with the disease.

4 Apr 2005

Alcoholism reduces male heart muscle’s ability to synthesize protein

The fact that men and women react differently to alcohol consumption and addiction, health and behavior risks, disease and death is well known and accepted. Women get drunker faster on less alcohol than men, but fewer women drink either occasionally or heavily, and men are more likely to become dependent on alcohol.

3 Apr 2005

Vical Incorporated issued two Canadian patents

Vical Incorporated announced today the issuance of two Canadian patents on the company's core technology, which involves direct administration of polynucleotide genetic material such as DNA or RNA.

29 Mar 2005

Claims about the experimental protein-based assay are not biologically plausible

In a new study, researchers present a "cautionary tale" about what may go wrong when using the fledgling science of proteomics to devise a diagnostic test for cancer.

15 Feb 2005