Proteostasis News and Research

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Each mammalian cell contains up to 20,000 proteins, all of which must be maintained and regulated. Proteostasis is a complex pathway that functions to maintain all of the proteins within and around a cell.
How diet and nutrition impacts lifespan

How diet and nutrition impacts lifespan

New mouse line reveals the state of protein balance in the mammalian brain for the first time

New mouse line reveals the state of protein balance in the mammalian brain for the first time

UC San Diego scientists develop new method to keep cultured cells healthy

UC San Diego scientists develop new method to keep cultured cells healthy

Research shows how loss of de-N-glycosylation enzyme causes detrimental effects

Research shows how loss of de-N-glycosylation enzyme causes detrimental effects

Study may lead to new treatments for a wide range of neurological conditions

Study may lead to new treatments for a wide range of neurological conditions

Experimental drug reverses key symptoms of Alzheimer's disease in mice

Experimental drug reverses key symptoms of Alzheimer's disease in mice

SARS-CoV-2 nucleoprotein can trigger α-synuclein amyloid fibril formation

SARS-CoV-2 nucleoprotein can trigger α-synuclein amyloid fibril formation

Researchers describe a new approach to treating Parkinson's disease

Researchers describe a new approach to treating Parkinson's disease

Researchers use EPR spectroscopy to learn more about "Parkinson protein"

Researchers use EPR spectroscopy to learn more about "Parkinson protein"

Potential new treatment approach to fatal COVID-19

Potential new treatment approach to fatal COVID-19

Researchers discover a new mode of protein degradation by ubiquitin-proteasome system

Researchers discover a new mode of protein degradation by ubiquitin-proteasome system

Protective brain-cell housekeeping mechanism may also be involved in regulating sleep

Protective brain-cell housekeeping mechanism may also be involved in regulating sleep

Researchers establish a gene expression profile associated with cachexia in cancer patients

Researchers establish a gene expression profile associated with cachexia in cancer patients

ADDF announces new awards through its Diagnostics Accelerator initiative

ADDF announces new awards through its Diagnostics Accelerator initiative

Scientists reverse learning and memory deficits with drugs in animal model of Down syndrome

Scientists reverse learning and memory deficits with drugs in animal model of Down syndrome

Stony Brook-led study reveals how proteome collapse process drives cell death and aging

Stony Brook-led study reveals how proteome collapse process drives cell death and aging

Scientists demonstrate influence of food odors on proteostasis

Scientists demonstrate influence of food odors on proteostasis

Antibiotic could protect against age-related brain diseases

Antibiotic could protect against age-related brain diseases

Researchers acquire new insights into DNA polymerases

Researchers acquire new insights into DNA polymerases

Scientists take important step to understand mechanisms that cause Huntington's disease

Scientists take important step to understand mechanisms that cause Huntington's disease