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Ribonucleic acid (RNA) is a biologically important type of molecule that consists of a long chain of nucleotide units. Each nucleotide consists of a nitrogenous base, a ribose sugar, and a phosphate.

Synthorx employs synthetic DNA technology to produce proteins containing novel amino acids

Synthorx Inc. announced today that the company has employed its proprietary protein expression system to successfully produce proteins containing novel amino acids. Using a semi-synthetic DNA template (containing the synthetic base pair X and Y), Synthorx scientists were able to produce RNA containing X and Y, which was used with an otherwise fully natural biological system, to efficiently direct the incorporation of multiple novel amino acids at different sites in proteins.

19 Aug 2015

Benitec prices initial public offering of 1,500,000 American Depositary Shares

Benitec Biopharma Limited, a clinical-stage biotechnology company, is pleased to announce the pricing of its U.S. initial public offering of 1,500,000 American Depositary Shares (ADSs), representing 30,000,000 fully paid ordinary shares of Benitec and warrants to purchase 500,000 ADSs, representing 10,000,000 fully paid ordinary shares, at a price of US$9.21 per ADS and US$0.01 per warrant.

18 Aug 2015

Physicians may now have tools to predict people at greater risk of attempting suicide

People being treated for bipolar disorder and other psychiatric illnesses are at greater risk of attempting suicide, but physicians may now have tools to predict which of those individuals will attempt it and intervene early to prevent such tragedies from occurring.

18 Aug 2015

Determining the dynein-dynactin complex structure: an interview with Dr Gabriel C. Lander

This is a macromolecular assembly is made up of two components, dynein and dynactin, that works to move molecular cargo (organelles, RNA, vesicles, proteins, viruses) along microtubule highways within our cells.

16 Aug 2015

Researchers use advanced photodynamic therapy to combat ovarian cancer in laboratory animals

Researchers at Oregon State University have made a significant advance in the use of photodynamic therapy to combat ovarian cancer in laboratory animals, using a combination of techniques that achieved complete cancer cell elimination with no regrowth of tumors.

14 Aug 2015

Researchers develop user-friendly platform for analyzing transcriptomic and epigenomic big data

Researchers at Cincinnati Children's Hospital Medical Center have developed a user-friendly, integrated platform for analyzing the transcriptomic and epigenomic "big data."

12 Aug 2015

Johns Hopkins researchers discover role of TDP-43 protein in autopsy brain cells of patients with ALS

Autopsies of nearly every patient with the lethal neurodegenerative disorder amyotrophic lateral sclerosis (ALS), and many with frontotemporal dementia (FTD), show pathologists telltale clumps of a protein called TDP-43. Now, working with mouse and human cells, Johns Hopkins researchers report they have discovered the normal role of TDP-43 in cells and why its abnormal accumulation may cause disease.

7 Aug 2015

Researchers identify genome-organizing mechanism that transmits vital genetic materials during mitosis

Chromosomes are responsible for carrying our genes and essentially protecting the information that helps ensure normal, healthy growth, with vital instructions being passed on from cell to cell by a process known as mitosis. While this copying mechanism has been well understood for decades, scientists have been unable to describe exactly how genetic information is protected and properly segregated as mitosis is happening.

7 Aug 2015

Celsion reports updated results from HEAT Study of ThermoDox in patients with primary liver cancer

Celsion Corporation, an oncology drug development company, today announced updated results from its retrospective analysis of the Company's 701-patient HEAT Study of ThermoDox, Celsion's proprietary heat-activated liposomal encapsulation of doxorubicin in combination with radiofrequency ablation (RFA) in primary liver cancer, also known as hepatocellular carcinoma (HCC).

6 Aug 2015

Penn research reveals additional pathway for origin of colon cancer

Cancer researchers already know of some oncogenes and other factors that promote the development of colon cancers, but they don't yet have the full picture of how these cancers originate and spread. Now researchers from the Perelman School of Medicine at the University of Pennsylvania have illuminated another powerful factor in this process.

6 Aug 2015

Autoantibody status fails to predict death risk in systemic sclerosis with PAH

Anticentromere and isolated nucleolar autoantibodies are prevalent in systemic sclerosis patients with pulmonary arterial hypertension, but they do not predict survival, US research shows.

5 Aug 2015

RNA-binding protein ROQUIN regulates response to DNA damage

Messenger (mRNA) molecules are a key component of protein biosynthesis. They are first transcribed as a "working copy" of the DNA and then translated into protein molecules.

3 Aug 2015

Isis Pharmaceuticals, AstraZeneca to develop antisense therapies for cardiovascular, metabolic, renal diseases

AstraZeneca and Isis Pharmaceuticals, Inc. today announced a strategic collaboration to discover and develop antisense therapies for cardiovascular, metabolic and renal diseases.

3 Aug 2015

Animal study shows children exposed to famine grow smaller, become susceptible to metabolic diseases

Starvation early in life can alter an organism for generations to come, according to a new study in roundworms. The effects are what Duke University biologist Ryan Baugh terms a "bet-hedging strategy."

3 Aug 2015

Reducing incorrect gene expression can extend lifespan of cells

Working with yeast and worms, researchers found that incorrect gene expression is a hallmark of aged cells and that reducing such "noise" extends lifespan in these organisms. The team published their findings this month in Genes & Development.

31 Jul 2015

New synthetic gene drives could one day improve human health and the environment

Gene drives are genetic elements - found naturally in the genomes of most of the world's organisms - that increase the chance of the gene they carry being passed on to all offspring, and thus, they can quickly spread through populations. Looking to these natural systems, researchers around the world, including some Wyss Institute scientists, are developing synthetic gene drives that could one day be leveraged by humans to purposefully alter the traits of wild populations of organisms to prevent disease transmission and eradicate invasive species.

31 Jul 2015

NEJM publishes positive clinical results from Phase 2 clinical study of volanesorsen

Isis Pharmaceuticals, Inc., the leader in RNA-targeted therapeutics, and Akcea Therapeutics, its wholly owned subsidiary, announced today that The New England Journal of Medicine (NEJM) has published positive clinical results from a Phase 2 clinical study evaluating volanesorsen (formerly ISIS-APOCIII Rx) in patients with very high to severely high triglycerides.

30 Jul 2015

UIC, Northwestern University researchers create first artificial ribosome

Researchers at the University of Illinois at Chicago and Northwestern University have engineered a tethered ribosome that works nearly as well as the authentic cellular component, or organelle, that produces all the proteins and enzymes within the cell. The engineered ribosome may enable the production of new drugs and next-generation biomaterials and lead to a better understanding of how ribosomes function.

30 Jul 2015

TGen scientist named a recipient of 2015 Bisgrove Scholars award

Dr. Candace Lewis, a research scientist at the Translational Genomics Research Institute, is one of five recipients of the 2015 Bisgrove Scholars award, Science Foundation Arizona announced today.

30 Jul 2015

New type of mycovirus can cause aspergillosis in humans

Researchers, led by Dr Robert Coutts, Leverhulme Research Fellow from the School of Life and Medical Sciences at the University of Hertfordshire, and Dr Ioly Kotta-Loizou, Research Associate at Imperial College, have discovered a completely novel type of mycovirus.

29 Jul 2015

RNA News and Research

Further Reading

Synthorx employs synthetic DNA technology to produce proteins containing novel amino acids

Benitec prices initial public offering of 1,500,000 American Depositary Shares

Physicians may now have tools to predict people at greater risk of attempting suicide

Determining the dynein-dynactin complex structure: an interview with Dr Gabriel C. Lander

Researchers use advanced photodynamic therapy to combat ovarian cancer in laboratory animals

Researchers develop user-friendly platform for analyzing transcriptomic and epigenomic big data

Johns Hopkins researchers discover role of TDP-43 protein in autopsy brain cells of patients with ALS

Researchers identify genome-organizing mechanism that transmits vital genetic materials during mitosis

Celsion reports updated results from HEAT Study of ThermoDox in patients with primary liver cancer

Penn research reveals additional pathway for origin of colon cancer

Autoantibody status fails to predict death risk in systemic sclerosis with PAH

RNA-binding protein ROQUIN regulates response to DNA damage

Isis Pharmaceuticals, AstraZeneca to develop antisense therapies for cardiovascular, metabolic, renal diseases

Animal study shows children exposed to famine grow smaller, become susceptible to metabolic diseases

Reducing incorrect gene expression can extend lifespan of cells

New synthetic gene drives could one day improve human health and the environment

NEJM publishes positive clinical results from Phase 2 clinical study of volanesorsen

UIC, Northwestern University researchers create first artificial ribosome

TGen scientist named a recipient of 2015 Bisgrove Scholars award

New type of mycovirus can cause aspergillosis in humans

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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