RNA Sequencing News and Research

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Study highlights previously unknown mechanisms involved in myeloma resistance

A group of researchers led by Maximillian Merz, MD, Assistant Professor of Oncology with the Myeloma team at Roswell Park Comprehensive Cancer Center, conducted the first prospective clinical trial investigating spatial heterogeneity in patients with either relapsed/refractory or newly diagnosed multiple myeloma.

7 Dec 2020

Scientists detect a sarbecovirus phylogenetically related to SARS-CoV-2 from bats in Japan

A team of researchers at the University of Tokyo in Japan have detected a sarbecovirus, called Rc-o319, which is phylogenetically positioned in the same clade as SARS-CoV-2 in Rhinolophus cornutus bats in Japan.

2 Dec 2020

Scientists use large-scale method to study genes associated with autism spectrum disorder

Scientists at Harvard University, the Broad Institute of MIT and Harvard, and MIT have developed a technology to investigate the function of many different genres in many different cell types at once, in a living organism.

1 Dec 2020

SARS-CoV-2 launches multipronged attack against host cell protein synthesis, study finds

An interesting new study throws a flood of light on how SARS-CoV-2 accomplishes its mission to infect and replicate within host cells while evading the host immune response.

27 Nov 2020

Novel cannabis plant extracts could protect against COVID-19

Researchers in Canada have conducted a study suggesting that novel Cannabis sativa extracts may decrease levels of the host cell receptor that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) uses to gain viral entry to target tissues.

26 Nov 2020

Triple RNA sequencing dissects gene expression of virus and fungi in infection processes

Organ and stem cell transplants are proven and frequently used methods in everyday modern clinical practice. However, even when performed regularly in specialized centers, some patients still experience a number of serious complications afterward.

19 Nov 2020

Researchers use proteogenomics to better understand the biological complexity of breast cancer

Researchers at Baylor College of Medicine, the Broad Institute of MIT and Harvard and other institutions have applied powerful proteogenomics approaches to better understand the biological complexity of breast cancer.

18 Nov 2020

Computational method could predict immunotherapy response in patients with advanced melanoma

A computational method that combines clinicodemographic variables with deep learning of pre-treatment histology images could predict response to immune checkpoint blockade among patients with advanced melanoma.

18 Nov 2020

Baricitinib drug can reduce mortality in patients with moderate to severe COVID-19

The rheumatoid arthritis drug baricitinib can block viral entry and reduce mortality in patients with moderate to severe COVID-19, according to translational research by an international team coordinated by researchers from Karolinska Institutet in Sweden.

16 Nov 2020

Immunotherapy combination shrinks rare angiosarcoma tumors in 25% of patients

Researchers from SWOG Cancer Research Network, a cancer clinical trials group funded by the National Cancer Institute's Division of Cancer Diagnosis and Treatment, part of the National Institutes of Health, have shown that the immunotherapy combination of ipilimumab and nivolumab shrinks rare angiosarcoma tumors in 25 percent of all patients, with some having an even stronger response to the drug combination.

15 Nov 2020

Immunotherapy drugs trigger inflammatory arthritis in subset of cancer patients

Since doctors began treating cancer patients with immunotherapy drugs called checkpoint inhibitors nearly a decade ago, they have observed that a subset of these patients experience a side effect that clinically looks like inflammatory arthritis.

10 Nov 2020

Spit testing may aid non-invasive concussion diagnosis

Doctors may soon be able to more accurately diagnose concussions by measuring the number of certain molecules in a person's saliva, according to Penn State College of Medicine researchers.

9 Nov 2020

Mouth may be primary route of SARS-CoV-2 infection and transmission

A new study published on the preprint server medRxiv in October 2020 shows that the virus also multiplies robustly in the oral cavity, indicating that saliva plays a role in viral transmission.

29 Oct 2020

Genetic analysis with RNA sequencing can increase diagnostic yield, shows study

In the world of rare genetic diseases, exome and genome sequencing are two powerful tools used to make a diagnosis. A recent addition to the toolkit, RNA sequencing, has been demonstrated to help researchers narrow down disease candidate variants identified first on exome and genome sequencing.

28 Oct 2020

RNA Sequencing News and Research

Study highlights previously unknown mechanisms involved in myeloma resistance

Scientists detect a sarbecovirus phylogenetically related to SARS-CoV-2 from bats in Japan

Scientists use large-scale method to study genes associated with autism spectrum disorder

SARS-CoV-2 launches multipronged attack against host cell protein synthesis, study finds

Novel cannabis plant extracts could protect against COVID-19

Triple RNA sequencing dissects gene expression of virus and fungi in infection processes

Researchers use proteogenomics to better understand the biological complexity of breast cancer

Computational method could predict immunotherapy response in patients with advanced melanoma

Baricitinib drug can reduce mortality in patients with moderate to severe COVID-19

Immunotherapy combination shrinks rare angiosarcoma tumors in 25% of patients

Immunotherapy drugs trigger inflammatory arthritis in subset of cancer patients

Spit testing may aid non-invasive concussion diagnosis

Mouth may be primary route of SARS-CoV-2 infection and transmission

Genetic analysis with RNA sequencing can increase diagnostic yield, shows study

Lung biomarkers may predict severe COVID-19

Multimodal mapping of immune landscape in pancreatic cancer could guide personalized therapies

Researchers explore SARS-CoV-2 at single cell resolution in human airway epithelial cells

Researchers report the discovery of innate immune signaling pathway in fibroblasts

Novel findings on mole growth could pave way for skin cancer treatments

Researchers explore molecular factors that drive the severity of COVID-19

Sequencing & Genomics: Elevating Science and Healthcare eBook

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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