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Six genomics research projects receive grants to address the role of ethnicity in major cancers

Leading cancer scientists working with the New York Genome Center (NYGC) announced today that grants are being awarded to fund six projects that address the role of ethnicity in several major cancer types, taking advantage of the diversity of patients being treated at health care institutions throughout the New York City area.

8 Sep 2020

Activation of fatty acid receptor causes masculinization of Japanese rice fish

A research collaboration based at Kumamoto University (Japan) has found that activation of PPARα, a fatty acid receptor that detects fatty acids in cells and regulates physiological functions, causes masculinization of Japanese rice fish (medaka).

5 Sep 2020

Underlying pathology of MIS-C in children following SARS-CoV-2 infection

Researchers at the Icahn School of Medicine at Mount Sinai, New York, have conducted a study that sheds light on the molecular underpinnings of multisystem inflammatory syndrome in children (MIS-C).

3 Sep 2020

Researchers propose unified nomenclature of neurons to cure brain disease

The human brain has about 100 billion neurons, linked in intricate ways, that the Spanish neuroanatomist Ramón y Cajal compared to "the impenetrable jungles where many investigators have lost themselves."

3 Sep 2020

ACE2/TMPRSS2 not expressed in pancreatic islet endocrine cells

A new study by researchers at the Vanderbilt University Medical Center and the University of Pennsylvania Perelman School of Medicine and published on the preprint server bioRxiv* in August 2020 reports that both key enzymes that are required for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) entry into the human host cell are lacking in the beta cells of the pancreatic islet. This rules out the direct injury hypothesis for impaired glucose control in patients with COVID-19 disease.

1 Sep 2020

Negligible ACE2 expression in human beta-cells

Now, a new study published on the preprint server bioRxiv reports that even though the fatality rate is significantly higher in diabetics, there is no evidence that this is due to direct viral infection of pancreatic beta cells, which produce the key hormone in glucose homeostasis, namely insulin.

1 Sep 2020

Two discoveries can lead to a new wave of more-complex organoid development

In back-to-back reports published Aug. 27, 2020, in Nature Communications, a team of scientists from Cincinnati Children's and Japan report discoveries that will be vital to a new wave of more-complex organoid development.

27 Aug 2020

Inhaled steroids reduce SARS-CoV-2-related genes in COPD

A new study published on the preprint server medRxiv* aims to explore the effects of treatment with ICS on the expression of specific genes related to SARS-CoV-2 infection in bronchial epithelial cells in a prospective interventional design.

25 Aug 2020

Combining expertise in organoids and sequencing technologies for ALS research

MDC researchers received a $150,000 pilot project grant from the Chan Zuckerberg Initiative's Neurodegeneration Challenge Network to investigate a defining feature of amyotrophic lateral sclerosis (ALS).

20 Aug 2020

Researchers identify new mechanism that causes leukemia

Every year, 1.1 million new cases of blood cancers are diagnosed worldwide. Presently, chemotherapy remains the most common and effective course of treatment.

13 Aug 2020

Study provides new insights into how ovarian cancer grows and evolves

In a paper published in the journal Cancer Research, professor Levi Waldron, post-doctoral fellow Ludwig Geistlinger, and colleagues at the Institute for Implementation Science in Population Health at the CUNY Graduate School of Public Health and Health Policy) provide new insights into how ovarian cancer grows and evolves within a person.

5 Aug 2020

New computational model can help determine drug viability

About 50% of people who take the drug infliximab for inflammatory bowel diseases, such as Crohn's disease, end up becoming resistant or unresponsive to it.

5 Aug 2020

Immunosuppressive steroids help tumors to evade the immune system

A new study has revealed that tumors can evade the immune system by telling immune cells to produce immunosuppressive steroids.

30 Jul 2020

From swab to sequencing - scalable method for identifying SARS-CoV-2

A research group headed by Stanford University scientists has developed a scalable, high throughput method to generate high fidelity whole genome and HLA sequencing, viral genomes, and representation of human transcriptome from single nasopharyngeal swabs of coronavirus disease (COVID19) patients. Their results are published on the medRxiv preprint server.

30 Jul 2020

Study identifies potential drug targets for developing new cancer immunotherapies

A study has revealed that tumours can evade the immune system by telling immune cells to produce immunosuppressive steroids.

30 Jul 2020

Scientists develop human lung organoids to study SARS-CoV-2 infection

Now, a new study published on the preprint server bioRxiv in July 2020 reports the development of a human distal lung culture system that can be functionally tested. This will help not only to understand how this infection produces disease but also to test the proliferative capacity of the stem cells in this part of the body.

30 Jul 2020