Remdesivir News and Research

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Researchers examine acriflavine's antiviral potential against SARS-CoV-2

Acriflavine is traditionally employed as a topical antiseptic, though has more recently been implicated as an antiviral agent at low doses, potentially by stimulating the production of interferon. In a new study recently uploaded to the bioRxiv* preprint server, the application of the drug to SARS-CoV-2 infection is investigated, demonstrating a broad activity towards a range of other betacoronaviruses.

24 Mar 2021

Researchers develop innovative biosensor that can detect and quantitate SARS-CoV-2 infection

Researchers have generated protease-activatable fluorescent and luminescent biosensors for SARS-CoV-2 MPro (main protease) and PLPro (papain-like protease) activity, one based on “flip” GFP (FlipGFP), and the other based on circularly permuted firefly luciferase (FFluc).

24 Mar 2021

Clofazimine inhibits coronaviruses including SARS-CoV-2, study finds

Researchers at the University of Hong Kong found that Clofazimine, a lipophilic antimicrobial riminophenazine dye used in combination with agents like rifampicin and dapsone to treat leprosy, inhibits coronaviruses, including the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes COVID-19 disease.

21 Mar 2021

Blocking folate metabolism could reduce SARS-CoV-2 viral replication in infected cells

The novel beta-coronavirus virus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and coronaviruses, in general, alter the host's cellular metabolism to support massive production of ~30 kB viral genomes and subgenomic viral RNAs. However, how this is achieved is largely unknown.

21 Mar 2021

Backtracking occurs within SARS-CoV-2 replication-transcription complex

Researchers continue to achieve a better understanding of SARS-CoV-2, the virus behind the ongoing COVID-19 pandemic. One such effort has been reported in a new preprint on the bioRxiv server, dealing with the phenomenon of backtracking.

16 Mar 2021

Genome-wide CRISPR screening used to identify factors essential for SARS-CoV-2 infection in humans

In a methodologically trailblazing paper published in the journal Nature Genetics, a team of Belgian scientists uncovered an assembly of coronavirus host factors that may be exploited to develop drugs against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), but also potentially forthcoming zoonotic coronaviruses.

14 Mar 2021

Pfizer’s newest vaccine plant has persistent mold issues, history of recalls

Pfizer's management knew last year there was "a mold issue" at the Kansas facility now slated to produce the drugmaker's urgently needed covid-19 vaccine, according to a Food and Drug Administration inspection report.

10 Mar 2021

ACTIV-3 clinical trial evaluating investigational COVID-19 therapies closes enrollment in two sub-studies

The ACTIV-3 clinical trial, which is evaluating the safety and efficacy of investigational therapeutics for COVID-19 in hospitalized patients, has closed enrollment in two sub-studies: one examining the investigational monoclonal antibody therapy VIR-7831, and another evaluating the investigational combination monoclonal antibody therapy containing BRII-196 and BRII-198.

5 Mar 2021

Study reveals a small molecule inhibits SARS-CoV-2 infection in cells

Researchers found a small molecule that inhibits different virus proteins and significantly reduces infection in cells. Combined with the antiviral remdesivir, its potency increases significantly, suggesting it may be a potential antiviral candidate for the treatment of COVID-19.

4 Mar 2021

Study reports persistent SARS-CoV-2 with increasing viral variants in pediatric patients

New research, published on medRxiv preprint server, has reported the effect of prolonged SARS-CoV-2 infection in immunocompromised children and young adults.

4 Mar 2021

Comparative analysis of SARS-CoV-2 antivirals leads to new potential treatment for COVID-19

Scientists compared the in vitro efficacy and cytotoxicity profiles of PF-00835231 and remdesivir in two human model systems for SARS-CoV-2 infection.

1 Mar 2021

Early tracheostomy could reduce recovery time in critical COVID-19, say researchers

A new study by researchers at the Northwestern University Feinberg School of Medicine, USA, reports the findings of a study on the safety of tracheostomy of critically ill patients and the feasibility of decannulation in most survivors. The researchers view this as a means to improve care in these patients

1 Mar 2021

Study explores individual differences of SARS-CoV-2 infection in ACE2-expressing stem cells

The clinical phenotype of COVID-19, caused by SARS-CoV-2, is remarkable for its wide range of severity among individual patients. Genetic variations are known to mediate part of these differences. To examine these differences, researchers in a new study used human induced pluripotent stem cells (iPSCs) from different genetically diverse individuals. These cells are used to model genetic disease since they contain the donor’s genetic information. Researchers use a panel of iPSCs from over 500 individuals. The researchers preferred undifferentiated iPSCs to reduce the time required to differentiate them, especially since infection is not always reliable.

25 Feb 2021

Influenza A virus defective interfering particles against SARS-CoV-2

In the search for a broadly acting pan-specific antiviral, an interdisciplinary team from Germany tested the previously proposed (for antiviral treatment against Influenza A infections) - Influenza A virus (IAV) defective interfering particles (DIPs). The research is published online on the bioRxiv preprint server.

23 Feb 2021

FDA-approved heart drug shows potential for treatment of SARS-CoV-2

A federally approved heart medication shows significant effectiveness in interfering with SARS-CoV-2 entry into the human cell host, according to a new study by a research team from Texas A&M University and The University of Texas Medical Branch.

22 Feb 2021

Some nutritional supplements may help prevent or mitigate COVID-19 severity

A new study in the Journal of dietary supplements shows that nutritional supplements, including several vitamins and the mineral zinc, may be useful in preventing the infection or reducing its severity if caught.

22 Feb 2021

Organ transplant patient dies after receiving Covid-infected lungs

Doctors say a woman in Michigan contracted covid-19 and died last fall two months after receiving a tainted double-lung transplant from a donor who turned out to harbor the virus that causes the disease — despite showing no signs of illness and initially testing negative.

22 Feb 2021

Chicken-derived antibody shows potent neutralizing capacity against SARS-CoV-2 in vitro

Researchers report on a Chicken-derived antibody against SARS-CoV-2, offering preliminary data on a potential therapeutic for COVID-19 warranting further research.

19 Feb 2021

Research shows rapid global spread of Southern California COVID-19 strain

A new strain of the coronavirus in Southern California, first reported last month by Cedars-Sinai, is rapidly spreading across the country and around the world as travelers apparently carry the virus with them to a growing list of global destinations, according to new research published today in the peer-reviewed Journal of the American Medical Association.

15 Feb 2021

SARS-CoV-2's resistance to remdesivir in vitro

A new preprint research paper posted to the bioRxiv server discusses the emergence of mutations in the SARS-CoV-2 virus, allowing it to escape the effects of the most commonly used antiviral drug, remdesivir.

14 Feb 2021

Remdesivir News and Research

Researchers examine acriflavine's antiviral potential against SARS-CoV-2

Researchers develop innovative biosensor that can detect and quantitate SARS-CoV-2 infection

Clofazimine inhibits coronaviruses including SARS-CoV-2, study finds

Blocking folate metabolism could reduce SARS-CoV-2 viral replication in infected cells

Backtracking occurs within SARS-CoV-2 replication-transcription complex

Genome-wide CRISPR screening used to identify factors essential for SARS-CoV-2 infection in humans

Pfizer’s newest vaccine plant has persistent mold issues, history of recalls

ACTIV-3 clinical trial evaluating investigational COVID-19 therapies closes enrollment in two sub-studies

Study reveals a small molecule inhibits SARS-CoV-2 infection in cells

Study reports persistent SARS-CoV-2 with increasing viral variants in pediatric patients

Comparative analysis of SARS-CoV-2 antivirals leads to new potential treatment for COVID-19

Early tracheostomy could reduce recovery time in critical COVID-19, say researchers

Study explores individual differences of SARS-CoV-2 infection in ACE2-expressing stem cells

Influenza A virus defective interfering particles against SARS-CoV-2

FDA-approved heart drug shows potential for treatment of SARS-CoV-2

Some nutritional supplements may help prevent or mitigate COVID-19 severity

Organ transplant patient dies after receiving Covid-infected lungs

Chicken-derived antibody shows potent neutralizing capacity against SARS-CoV-2 in vitro

Research shows rapid global spread of Southern California COVID-19 strain

SARS-CoV-2's resistance to remdesivir in vitro

Achieving and maintaining ISO 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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