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Metformin prevents pulmonary or lung inflammation in animals infected with SARS-CoV-2

Metformin is a widely prescribed blood sugar-lowering drug. It is often used as an early therapy (in combination with diet and lifestyle changes) for type 2 diabetes, which afflicts more than 34 million Americans.

11 Jun 2021

Nanobodies from nanomice and llamas show potent neutralizing activity against SARS-CoV-2 variants

While several COVID-19 vaccines have been approved to date, the constant evolution of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) receptor-binding domain (RBD) has challenged the efficacy of these vaccines.

11 Jun 2021

Cross-sectional study explores differences in biomarkers in fulminant and non-fulminant COVID-19 myocarditis

Researchers from the US recently conducted a study to examine the clinical course and echocardiographic and lab testing across clinically defined fulminant and non-fulminant COVID-19 myocarditis. This study is published on the preprint server, medRxiv.*

11 Jun 2021

In vivo protection from emerging SARS-CoV-2 variants by protein nanoparticle vaccine

Researchers in the United States have developed a new coronavirus disease 2019 (COVID-19) vaccine that induced potent neutralizing antibodies against variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in animal models.

10 Jun 2021

Shark vNAR antibodies inhibit SARS-CoV-2 variants in vitro

Researchers in the UK and Austria have identified a novel class of antibodies that is highly effective at neutralizing the original strain of severe acute respiratory syndrome (SARS-CoV-2) and maintaining blocking activity against certain viral variants that have emerged.

10 Jun 2021

Labor department issues emergency rules to protect health care workers from Covid

Labor Department officials on Thursday announced a temporary emergency standard to protect health care workers, saying they face "grave danger" in the workplace from the ongoing coronavirus pandemic.

10 Jun 2021

The longevity of SARS-CoV-2 antibodies and their cross-neutralization against variants of concern

In a new study by researchers in the UK, the activity of neutralizing antibodies collected from the sera of individuals that contracted COVID-19 during the first wave of the pandemic is tested against variants of concern the B.1.1.7 (or UK) variant and the B.1.351 (or South African) variant, demonstrating somewhat reduced potency of neutralization towards these strains.

10 Jun 2021

Bovine-derived polyclonal antibodies exhibit high efficacy in neutralizing SARS-CoV-2 variants

A team of scientists in Estonia has recently evaluated the therapeutic/prophylactic efficacy of anti-SARS-CoV-2 polyclonal antibodies derived from the colostrum of immunized cows.

10 Jun 2021

Is B.1.617.2 more transmissible than earlier SARS-CoV-2 variants?

A new study, released as a preprint on the medRxiv* server, reports that the B.1.617.2 variant is possibly more transmissible than earlier variants, based on the discovery that the serial intervals were not prolonged with this strain.

10 Jun 2021

Are pre-existing Vitamin D deficiencies linked to COVID-19 severity and mortality?

Even as the COVID-19 pandemic continues to spread and new variants of SARS-CoV-2 emerge, much remains to be known about why severity varies so unpredictably between individuals. A new study, released as a preprint on the medRxiv* server, elucidates the relationship between Vitamin D and COVID-19 severity.

10 Jun 2021

Could the COVID-19 vaccination rollout protect against future coronavirus outbreaks?

A new study suggests that the rollout of vaccines against the COVID-19 pandemic may be significant not only in preventing infections by SARS-CoV-2 but other endemic and pandemic-potential coronaviruses (CoVs) as well.

10 Jun 2021

Local anesthetic procaine inhibits SARS-CoV-2 in vitro

Research has shown that procaine and procaine-hydrochloride can reduce replication of SARS-CoV-2 and influenza A viruses in infected cells and reduce the production of cytokines by the viruses, making them potentially useful for treating COVID-19.

10 Jun 2021

New article explains the pros and cons of nasal vaccines

Vaccines are mostly synonymous with needles, an efficient and effective way to provide immunity to myriad infections. As COVID-19 vaccination efforts roll out across the U.S. and the world, some experts believe that a vaccine administered through the nose could be just as effective and easier to administer.

10 Jun 2021

Eldelumab and Fenofibrate show potential for COVID-19

In a new study posted to the medRxiv* preprint server, researchers from the University of Pittsburgh and Barrow Neurological Institute report the results of their analysis of several RNA-Seq studies and used computational approaches to discover potential drugs against COVID-19.

10 Jun 2021

Nose-to-brain: Nasal delivery of biopharmaceuticals to the brain

Placing medications as close as possible to the site of the disease: This sounds completely believable in theory, but is unfortunately not so simple in practice. While this works well for many drugs via the bloodstream or the digestive tract, it does not apply to the brain.

9 Jun 2021

Trained dogs can accurately identify COVID-19 by scent

An interesting new medRxiv* preprint reveals that with careful training, the exquisite scent sensitivity of dogs may be exploited to rule out the presence of coronavirus disease 2019 (COVID-19) in human beings in real-time.

9 Jun 2021

Review of COVID-19's long-term effects

In a recent study, Canadian researchers documented the prevalence of post-COVID-19 conditions 4-12 weeks (short-term) and >12 weeks (long-term), by conducting a systematic review of peer-reviewed literature. This work is posted to the medRxiv* preprint server.

9 Jun 2021

Respiratory News and Research

Metformin prevents pulmonary or lung inflammation in animals infected with SARS-CoV-2

Nanobodies from nanomice and llamas show potent neutralizing activity against SARS-CoV-2 variants

Cross-sectional study explores differences in biomarkers in fulminant and non-fulminant COVID-19 myocarditis

In vivo protection from emerging SARS-CoV-2 variants by protein nanoparticle vaccine

Shark vNAR antibodies inhibit SARS-CoV-2 variants in vitro

Labor department issues emergency rules to protect health care workers from Covid

The longevity of SARS-CoV-2 antibodies and their cross-neutralization against variants of concern

Bovine-derived polyclonal antibodies exhibit high efficacy in neutralizing SARS-CoV-2 variants

Is B.1.617.2 more transmissible than earlier SARS-CoV-2 variants?

Are pre-existing Vitamin D deficiencies linked to COVID-19 severity and mortality?

Could the COVID-19 vaccination rollout protect against future coronavirus outbreaks?

Local anesthetic procaine inhibits SARS-CoV-2 in vitro

New article explains the pros and cons of nasal vaccines

Eldelumab and Fenofibrate show potential for COVID-19

Nose-to-brain: Nasal delivery of biopharmaceuticals to the brain

Trained dogs can accurately identify COVID-19 by scent

Review of COVID-19's long-term effects

Warmer conditions are not enough to prevent COVID-19 transmission, research shows

SARS-CoV-2 enzyme inhibitors among drugs screened for repurposing

New cell-penetrating peptide may protect against life-threatening microbial inflammation

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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