Sarcoma News and Research

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Treating soft tissue sarcoma with shorter radiation treatment found to be safe, effective

A new study led by researchers at the UCLA Jonsson Comprehensive Cancer Center found that treating soft tissue sarcoma with radiation over a significantly shorter period of time is safe, and likely just as effective, as a much longer conventional course of treatment.

13 Feb 2020

St. Jude's researchers receive ACGT grant to tackle challenges of pediatric sarcomas

An innovative approach to tackling the challenges of pediatric sarcomas is being pursued by researchers at St. Jude Children's Research Hospital (Memphis, Tennessee) with a new grant from Alliance for Cancer Gene Therapy.

9 Feb 2020

Researchers identify determinant protein for metastasis in alveolar rhabdomyosarcoma

Rhabdomyosarcoma is the most common childhood cancer in the soft tissues, and it is mainly originated in the muscles.

29 Jan 2020

Scientists discover how B-cells in tumor cells promote a favorable immunotherapy response

The white blood cells are potent fighters that protect the body against foreign invaders, including pathogens and cancer cells. Scientists have found that the presence of B cells, which are powerhouses, in tumor cells, combat the disease from within.

16 Jan 2020

Study sheds light on the role of B cells in cancer immunotherapy

Cancer patients responded better to immunotherapy and had a better prognosis if their melanoma tumors contained specific clusters of B cells, according to new research from Lund University in Sweden.

16 Jan 2020

B cell count tells how certain cancers will respond to immunotherapy

Some melanomas, sarcomas and renal cell carcinomas, but not all, have been found to respond dramatically to new drugs called immune checkpoint blockers, which exploit the body’s known capability to mount an immune response against the foreign antigen-bearing tumor cells.

15 Jan 2020

Houston Methodist scientist proposes new combination treatment for Ewing sarcoma

Ewing sarcoma, an aggressive tumor that commonly affects bones in adolescents and young adults, is diagnosed in about 225 American children and teens every year, accounting for about 1 percent of pediatric cancers.

16 Dec 2019

Broadly expressed metabolic approach could make sarcoma susceptible to targeted therapies

Soft tissue sarcoma cells stop a key metabolic process which allows them to multiply and spread, and so restarting that process could leave these cancers vulnerable to a variety of treatments.

26 Nov 2019

Gene-editing technique CRISPR trialed for first time as cancer treatment

The go-ahead has been given for the first trials using CRISPR as an alternative therapy for treating cancer.

6 Nov 2019

Study reveals novel druggable driver gene in human gastrointestinal stromal tumors

Sarcomas - cancers that arise from transformed mesenchymal cells (a type of connective tissue) - are quite deadly. Gastrointestinal stromal tumors are the most common human sarcoma and are initiated by activating mutations in the KIT receptor tyrosine kinase.

24 Oct 2019

Epigenetic changes can lead to development of GISTs, other cancers

Most cases of gastrointestinal stromal tumor (GIST), a type of soft-tissue cancer (sarcoma), are caused by mutations in genes that can be effectively targeted with drugs that inhibit the activity of rogue cancer-promoting enzymes.

16 Oct 2019

Research may help explain how liquid organelles in cells coexist without merging

New research may help to explain an intriguing phenomenon inside human cells: how wall-less liquid organelles are able to coexist as separate entities instead of just merging together.

10 Oct 2019

Researchers propose potential treatment for Ewing sarcomas

Ewing sarcoma is a bone cancer that appears mainly in teenagers. Due to a single defective gene, once it spreads to distant organs it is hard to treat. Researchers at the Weizmann Institute of Science have discovered molecular interactions underlying Ewing sarcomas and proposed a potential treatment, which has shown promise in a study in mice.

2 Oct 2019

Openspecimen chosen to manage ARTB's biospecimen library

The Auckland Region Tissue Bank is a critical component in New Zealand’s medical research infrastructure. As a central facility for storing blood and tissue samples, they have a library that could hold the secrets to unlocking cures for existing and future chronic diseases and illnesses.

25 Sep 2019

Scientists identify a potentially novel avenue to treat non-small cell lung cancers

Researchers at the University of Kentucky Markey Cancer Center have made a breakthrough discovery that solves a mystery long forgotten by science and have identified a potentially novel avenue in pre-clinical models to treat non-small cell lung cancers.

13 Sep 2019

Researchers discover a molecule that regulates tumor development in different types of cancers

Researchers from the Josep Carreras Leukemia Research Institute, discover that a non-coding region of the genome originates a key molecule for the proliferation of tumors in breast cancer and some types of sarcoma.

5 Sep 2019

Super-powered immune cells to attack tumors

Ground-breaking immune therapy promises to deliver vital evidence in the fight against cancer as researchers from the Centre for Cancer Biology open a new clinical trial using genetically engineered immune cells to treat solid cancers.

23 Aug 2019

Study sheds light on likely conserved functions of gammaherpesvirus microRNAs

The discovery of thousands of host mRNAs targeted by gammaherpesvirus microRNAs (miRNAs) could shed light on the biology of gammaherpesviruses and how these pathogens establish lifelong infections, according to a study published August 8 in the open-access journal PLOS Pathogens by Scott Tibbetts of the University of Florida, and colleagues.

From PLOS ONE 13 Aug 2019

An unexpected developmental hierarchy in a rare disease affecting young children

Langerhans cell histiocytosis is a rare disease affecting primarily young children. While LCH may heal by itself without treatment in some patients, others require intensive chemotherapy and suffer from long-term consequences, or may even succumb to the disease.

26 Jul 2019

Researchers develop new compound to block therapeutic target in aggressive blood cancer

Researchers at the UNC Lineberger Comprehensive Cancer Center have discovered a hyperactive cell signal that contributes to tumor growth in an aggressive blood cancer.

23 Jul 2019