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Mouse study shows potential new way to unlock the power of immunotherapy for cancer patients

Immunotherapy has revolutionized cancer treatment by stimulating the patient's own immune system to attack cancer cells, yielding remarkably quick and complete remission in some cases. But such drugs work for less than a quarter of patients because tumors are notoriously adept at evading immune assault.

11 Aug 2020

Chemotherapy not commonly used when treating adults with localized sarcoma

UCLA researchers have found that chemotherapy is not commonly used when treating adults with localized sarcoma, a rare type of cancer of the soft tissues or bone.

6 Aug 2020

Stand Up To Cancer announces $1.1 million in funding to foster collaborative research

Stand Up To Cancer announced today five new awards that will cut across institutional and national lines to foster collaborative research and explore new paths to improve cancer treatment.

29 Jul 2020

Mouse orthotopic model was used to determine personalized therapy for relapse sarcoma

A team from IDIBELL and ICO, using a mouse orthotopic model, conducted a real-time personalized oncology study to test the best therapeutic option to treat a type of relapse sarcoma. Malignant Peripheral Nerve Sheath Tumor are very aggressive and do not usually have a good prognosis, especially if complete surgical excision cannot be achieved.

23 Jul 2020

Hollings Cancer Center researcher receives NCI grants for cancer immunotherapy studies

Hollings Cancer Center researcher Jessica Thaxton, Ph.D., is the recipient of two grants totaling $3.4 million from the National Cancer Institute for her work in cancer immunotherapy and cell stress, one of which is part of the Cancer Moonshot Initiative on immunometabolism.

23 Jul 2020

Research could lead to more efficient cellular immunotherapies for advanced cancers

Adoptive cell transfer immunotherapy is one of the most promising new treatments for people with hard-to-treat cancers.

23 Jul 2020

Discovery hints at novel therapeutic target for Ewing sarcoma

New insights into Ewing sarcoma, an aggressive childhood cancer, were published July 15 in the prestigious journal Nature. Researchers from the Long School of Medicine at The University of Texas Health Science Center at San Antonio contributed to the study.

16 Jul 2020

Novel drug could enable the immune system to attack ovarian cancer

A drug known as SP-2577 could help enable the body's own immune system to attack ovarian cancer, according to a study led by the Translational Genomics Research Institute, an affiliate of City of Hope.

13 Jul 2020

Breakthrough discovery could lead to ‘kinder’ treatments for childhood bone cancer

Researchers at the University of East Anglia and University of Manchester have made an important breakthrough that could lead to ‘kinder’ treatments for children with bone cancer, and save lives.

13 Jul 2020

A metabolic enzyme drives B cell lymphomas and could be a potential drug target

Scientists at the Sloan Kettering Institute have found that increased activity of a normal metabolic enzyme can lead to cancer. The enzyme, SHMT2, is a driver of a large portion of B cell lymphomas and could be a potential drug target.

24 Jun 2020

Improving cancer therapies by exploiting drug resistance in cancer

News-Medical talks to Professor David Thomas about his recent research identifying the mechanisms behind cancer cells developing resistance to drugs.

23 Jun 2020

Study provides molecular explanation to a longstanding mystery in viral oncology

The oncogenic herpesvirus (HHV8 or KSHV) causes a cancer known as Kaposi's Sarcoma. An international team of scientists led by the University of Helsinki has discovered key factors that control the genome maintenance and replication of a virus responsible for lymphatic vascular cancer.

10 Jun 2020

Study investigates combined effects of cancer therapy and inherited genetics

Scientists at St. Jude Children's Research Hospital are studying the combined effect of cancer treatments and inherited mutations in DNA-repair genes.

5 Jun 2020

SARS-CoV-2 infected patients who undergo surgery experience worse postoperative outcomes

Patients undergoing surgery after contracting coronavirus are at greatly increased risk of postoperative death, a new global study published in The Lancet reveals.

2 Jun 2020

Adoptive T-cell therapy targeting MAGE-A4 achieves responses in patients with multiple solid tumors

The adoptive T-cell therapy ADP-A2M4, which is engineered to express a T-cell receptor (TCR) directed against the MAGE-A4 cancer antigen, achieved responses in patients with multiple solid tumor types, including synovial sarcoma, head and neck cancer and lung cancer, according to results from a Phase I clinical trial led by researchers at The University of Texas MD Anderson Cancer Center.

29 May 2020

Immunotherapy treatment shows promise for some patients with advanced rare cancers

A study conducted by researchers at The University of Texas MD Anderson Cancer Center demonstrated acceptable toxicity and anti-tumor activity in patients with four types of advanced, hard-to-treat rare cancers.

20 Mar 2020

New type of adoptive cell therapy could target prostate and pancreatic cancers in humans

In experiments with mice, researchers at the Johns Hopkins Kimmel Cancer Center say they have slowed the growth of transplanted human prostate and pancreatic cancer cells by introducing bone marrow cells with a specific gene deletion to induce a novel immune response.

5 Mar 2020

Comprehensive tumor profiling reveals why osteosarcoma does not respond to immunotherapy

Comprehensive profiling of tumor samples taken from patients with osteosarcoma shows that multiple factors contribute to the traditionally poor responses observed from treatment with immune checkpoint inhibitors, according to new research from The University of Texas MD Anderson Cancer Center.

22 Feb 2020

Researchers design new drug cocktail to kill brain and soft tissue cancers

Researchers at the USC Viterbi School of Engineering have designed a new drug cocktail that kills some types of brain and soft tissue cancers by tricking the cancer cells to behave as if they were starving for their favorite food--glucose.

20 Feb 2020

A high number of lifetime sexual partners raises cancer risk

A new study seems to reinforce traditional common sense and good morals: people who play around with sex tend to have a higher risk of cancer. The study published online in the journal BMJ Sexual and Reproductive Health in February 2020 shows that having ten or more sex partners increases the risk of cancer in both men and women. And in women, this pattern of sexual behavior increases the chances of a chronic debilitating illness.

13 Feb 2020

Sarcoma News and Research

Mouse study shows potential new way to unlock the power of immunotherapy for cancer patients

Chemotherapy not commonly used when treating adults with localized sarcoma

Stand Up To Cancer announces $1.1 million in funding to foster collaborative research

Mouse orthotopic model was used to determine personalized therapy for relapse sarcoma

Hollings Cancer Center researcher receives NCI grants for cancer immunotherapy studies

Research could lead to more efficient cellular immunotherapies for advanced cancers

Discovery hints at novel therapeutic target for Ewing sarcoma

Novel drug could enable the immune system to attack ovarian cancer

Breakthrough discovery could lead to ‘kinder’ treatments for childhood bone cancer

A metabolic enzyme drives B cell lymphomas and could be a potential drug target

Improving cancer therapies by exploiting drug resistance in cancer

Study provides molecular explanation to a longstanding mystery in viral oncology

Study investigates combined effects of cancer therapy and inherited genetics

SARS-CoV-2 infected patients who undergo surgery experience worse postoperative outcomes

Adoptive T-cell therapy targeting MAGE-A4 achieves responses in patients with multiple solid tumors

Immunotherapy treatment shows promise for some patients with advanced rare cancers

New type of adoptive cell therapy could target prostate and pancreatic cancers in humans

Comprehensive tumor profiling reveals why osteosarcoma does not respond to immunotherapy

Researchers design new drug cocktail to kill brain and soft tissue cancers

A high number of lifetime sexual partners raises cancer risk

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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