Severe Acute Respiratory News and Research

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How the SARS-CoV-2 Omicron variant spike protein is changing

The study assesses the degree to which the D614G mutation in the SARS-CoV-2 RBD allows access of spike protein trimers to LA-binding-like conformations.

21 Dec 2021

Comparison of point-of-care SARS-CoV-2 diagnostic kits

A multinational group of scientists investigates the performance characteristics of several point-of-care diagnostic kits for SARS-CoV-2.

21 Dec 2021

What are the long-term effects of COVID-19 on mental health?

Researchers determine the long-term adverse mental health symptoms associated with COVID-19 by estimating acute infection severity.

21 Dec 2021

Molecular mechanism of SARS-Cov-2-induced thrombosis

Researchers demonstrate that the exposure of platelets to the SARS-CoV-2 spike protein promotes their activation and adhesion.

21 Dec 2021

Booster doses offer broader protection in SARS-CoV-2 infected and vaccinated individuals

Researchers determined IgG titers of vaccinated healthcare workers 11 months following primary COVID-19 vaccination.

21 Dec 2021

Severe COVID-19 found to be associated with disrupted intestinal Peyer’s patches

A new study demonstrates significantly altered structure and cellularity of Peyer’s patches in deceased COVID-19 patients.

21 Dec 2021

Diagnostic assays that use the 2019-nCoV-N1 primer-probe are unlikely to be impacted by Omicron variant

A new study aimed to detect the genomic material of SARS-CoV-2 and its variants, such as the recently emerged variant of concern (VOC) Omicron.

21 Dec 2021

Effect of T cell reactivity in COVID-19 infection and vaccination

Researchers recently developed an immunodiagnostic T cell assay to classify T cell immune responses of the subjects based on their coronavirus disease 2019 infection and vaccination history.

21 Dec 2021

Do reactive oxygen species play a role in fighting COVID-19?

Serum-free thiols are known to reflect the activity of reactive oxygen species in the body, and researchers have been examining the difference in these thiols in COVID-19 patients.

21 Dec 2021

Crude infection fatality rate is a key indicator in understanding COVID-19 mortality

Researchers leveraged recent data sources and broadly applicable modeling strategies to calculate the COVID-19 crude infection fatality rate (cIFR) in 77 countries from 28 March 2020 to 31 March 2021

21 Dec 2021

Stabilizing the long-term endemic behavior of COVID-19

Researchers used a classic age and contact structured model to explore the several reopening and vaccination coverage scenarios regarding the COVID-19 pandemic.

21 Dec 2021

Younger cancer patients at particularly increased risk of mortality from COVID-19

Systematic reviews and meta-analysis were conducted to identify the impact of SARS-CoV-2 in cancer patients based on tumor type, age, and treatment, and any novel risk factors for COVID-19 in cancer patients

21 Dec 2021

Understanding SARS-CoV-2-induced systemic amyloidosis

A new study proposed that inflammation combined with aggregates of amyloidogenic peptides of SARS-CoV-2 S proteins might induce systemic amyloidosis.

21 Dec 2021

Identifying a recurring pattern in broadly neutralizing antibodies that can target an epitope on SARS-CoV-2

Interesting research decrypts a recurring sequence in antibodies against severe acute respiratory syndrome 2 (SARS-CoV-2) and identifies it to be a board neutralizing antibody that targets a conserved epitope on the SARS-CoV-2 receptor-binding domain (RBD) of the spike protein.

21 Dec 2021

Risk of hospitalization for infants and children with COVID-19 below 1%

Children are a low-risk group for COVID-19 following infection with SARS-CoV-2, with less than 2% of European hospitalizations with the disease being in children below the age of 19.

21 Dec 2021

Children with isolated symptoms as likely as those with multiple symptoms to test COVID-19 positive

A new study compares rates of coronavirus disease 2019 infection in children who reported no symptoms, one isolated symptom, or two or more symptoms during the circulation of the Delta variant.

21 Dec 2021

Efficacy of the mRNA-1273 vaccine against emerging COVID-19 variants

A new study emphasized the effectiveness of two doses of mRNA-1273 in preventing infection with SARS-CoV-2 and hospital admission with covid-19 due to variants including delta.

21 Dec 2021

Estimating vaccine efficacy against COVID-like illness from omicron and other COVID-19 variants

A new study combines real-time syndromic surveillance data from daily cross-sectional surveys with a COVID-like illness (CLI) prevalence-based vaccine efficacy estimator to better explain the early onset of the omicron variant.

21 Dec 2021

Researchers create 'UV Curtain' that can sterilize rooms against coronaviruses

Researchers from the Ludwig Maximilian University of Munich have created a new system to protect areas from the virus, using a light-emitting diode (LED)-based ultraviolet C (UV-C) light curtain. Specific wavelengths of UV-C are known to inactivate viruses and bacteria, and this tool could help keep areas sterile.

20 Dec 2021

Booster shots improve CD8+ T cell response to SARS-CoV-2 in animal model

In a new study, published on the bioRxiv* preprint server, scientists showed in a mice model that three doses of the same synthetic peptide vaccine, eliciting an exclusive CD8+ T cell response against one SARS-CoV-2 Spike epitope, protected against lethal SARS-CoV-2 infection, in the absence of neutralizing antibodies. Researchers also showed that the third dose resulted in superior generation of effector-memory T cells in the circulation and tissue-resident memory T (TRM) cells.

20 Dec 2021

Severe Acute Respiratory News and Research

How the SARS-CoV-2 Omicron variant spike protein is changing

Comparison of point-of-care SARS-CoV-2 diagnostic kits

What are the long-term effects of COVID-19 on mental health?

Molecular mechanism of SARS-Cov-2-induced thrombosis

Booster doses offer broader protection in SARS-CoV-2 infected and vaccinated individuals

Severe COVID-19 found to be associated with disrupted intestinal Peyer’s patches

Diagnostic assays that use the 2019-nCoV-N1 primer-probe are unlikely to be impacted by Omicron variant

Effect of T cell reactivity in COVID-19 infection and vaccination

Do reactive oxygen species play a role in fighting COVID-19?

Crude infection fatality rate is a key indicator in understanding COVID-19 mortality

Stabilizing the long-term endemic behavior of COVID-19

Younger cancer patients at particularly increased risk of mortality from COVID-19

Understanding SARS-CoV-2-induced systemic amyloidosis

Identifying a recurring pattern in broadly neutralizing antibodies that can target an epitope on SARS-CoV-2

Risk of hospitalization for infants and children with COVID-19 below 1%

Children with isolated symptoms as likely as those with multiple symptoms to test COVID-19 positive

Efficacy of the mRNA-1273 vaccine against emerging COVID-19 variants

Estimating vaccine efficacy against COVID-like illness from omicron and other COVID-19 variants

Researchers create 'UV Curtain' that can sterilize rooms against coronaviruses

Booster shots improve CD8+ T cell response to SARS-CoV-2 in animal model

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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