Severe Acute Respiratory News and Research

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Small negative lifestyle changes during COVID-19 lockdown could accumulate, say researchers

An interesting new study by researchers in Australia, which has been published in the journal PLOS ONE, suggests that lifestyle changes due to pandemic restrictions on outdoor mobility have been small. But they warn that these may accumulate over time.

8 Mar 2021

Novel bioinformatics tool could help improve COVID-19 diagnosis

An interesting new study by researchers at the University of Liverpool, University of Bristol and Public Health England in the UK describes a novel bioinformatics tool used to detect subgenomic messenger ribonucleic acid (mRNA) sequences from the virus. This may help develop new diagnostic tools and model the transmission of the virus.

8 Mar 2021

How can physicians distinguish between COVID-19 persistence and SARS-CoV-2 reinfection?

One of the most challenging tasks of physicians has been differentiating between persistent COVID-19 and SARS-CoV-2 reinfection. Recently, a team of researchers analyzed SARS-CoV-2 sequences from the publicly available reports on reinfection and persistence. They further characterized the markers of reinfecting sequences and studied the mutation rate in newly evolved persistent variants.

8 Mar 2021

Study analyzes COVID fatality rate using age and GDP as proxies for the quality and abundance of healthcare

The COVID-19 pandemic has claimed over 2.5 million lives globally as of today. The case fatality rate (CFR) is an important parameter in COVID-19 mortality research and is defined as the ratio of the number of infected cases to the death toll number.

7 Mar 2021

Study confirms B.1.1.7 variant of SARS-CoV-2 is more transmissible

A new modeling study published in the journal Science estimates the B.1.1.7 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant is 43% to 90% more transmissible than previous coronavirus variants. The variant was initially found in Southeast England last fall.

7 Mar 2021

Saliva testing has high accuracy in detecting early cases of SARS-CoV-2

New research finds saliva testing has a high sensitivity for detecting severe acute respiratory syndrome 2 (SARS-CoV-2) in both symptomatic and asymptomatic patients.

7 Mar 2021

Children may transmit SARS-CoV-2 at same level as adults, suggests study

Researchers studied SARS-CoV-2 viral loads in over a thousand individuals, including both adults and children. They found the loads to be comparable, suggesting they may play an equal role in COVID-19 transmission.

5 Mar 2021

SARS-CoV-2 escapes host immune responses by modulating dendritic cell maturation

A team of scientists from Italy and the USA has recently explored the maturation pattern of conventional dendritic cells (cDCs) during SARS-CoV-2 infection.

5 Mar 2021

One dose of SARS-CoV-2 vaccine candidate boosts neutralizing antibody response in COVID-19 convalescents

A new study details the results from a single dose of the FINLAY FR 1A recombinant dimeric receptor-binding domain (RBD) base vaccine during a phase I clinical trial with 30 COVID-19 convalescents to test its capacity for boosting natural immunity.

5 Mar 2021

A SARS-CoV-2 spike protein adjuvant vaccine candidate produces durable rapid protection in vivo

A recent study reports the safety and high efficacy of an adjuvanted vaccine candidate against SARS-CoV-2 and the complications of COVID-19.

5 Mar 2021

SARS-CoV-2 proteins are potent suppressors of innate immunity

A new study describes the strong immune-suppressing activity of SARS-CoV-2 genes, among other coronavirus genes.

5 Mar 2021

Failing to communicate COVID-19 vaccine uncertainties has negative consequences

All healthcare decisions come with uncertainty. In addition to the general risks that a healthcare professional is aware of, there is also uncertainty surrounding the associated probabilities, called ambiguity or radical uncertainties. These uncertainties grow as vaccines generated at an unprecedented pace are administered across the world.

4 Mar 2021

Preclinical study finds immune benefit in unrefrigerated Soligenix coronavirus vaccines

A new study reports positive outcomes from two new vaccine candidates. The research, led by Axel T. Lehrer from the University of Hawaii at Manoa, studied mice's immune response when administered the CoVaccine HT adjuvant with an insect-cell expressed SARS-CoV-2 spike protein ectodomain.

4 Mar 2021

Study explains how the B.1.1.7 SARS-CoV-2 variant is more transmissible

New research led by Thushan I. de Silva from the University of Sheffield proposes that increases in subgenomic RNA (sgRNA) expression cause increased viral transmissibility and subsequent infection. They suggest the ORF9 protein, found in high amounts of sgRNA, could be regulating interferon responses.

4 Mar 2021

Novavax COVID-19 vaccine shows efficacy against South African SARS-CoV-2 variant

Researchers in the United States and South Africa report that the NVX-CoV2373 vaccine from Novavax has proved effective at preventing coronavirus disease (COVID-19) caused by the B.1.351 variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that has recently emerged in South Africa.

4 Mar 2021

Brazilian SARS-CoV-2 P.1 variant shows resistance to antibody neutralization

Researchers in the United States say the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant – P.1 – that has recently emerged in Brazil shows a worrying level of resistance to neutralization by antibodies.

4 Mar 2021

Combining terpenes and cannabidiol may be highly active against human coronaviruses

A group of researchers from a well-known technology company in Israel showed a significant antiviral effect of a combination of terpenes and cannabidiol against a human coronavirus strain 229E. This exciting and first-of-its-kind report is currently available on the bioRxiv preprint server.

4 Mar 2021

Study reveals a small molecule inhibits SARS-CoV-2 infection in cells

Researchers found a small molecule that inhibits different virus proteins and significantly reduces infection in cells. Combined with the antiviral remdesivir, its potency increases significantly, suggesting it may be a potential antiviral candidate for the treatment of COVID-19.

4 Mar 2021

Delayed detection of oral fluid anti-SARS-CoV-2 antibodies increases the time to viral clearance

A prospective observational study has revealed that the late appearance of anti-SARS-CoV-2 antibodies in oral fluid, absence of fever as an early symptom, and elevated BMI are associated with delayed clearance of viral RNA in mild to moderate COVID-19 patients.

4 Mar 2021

Researchers show potential benefits of delaying second mRNA COVID-19 vaccine dose

The currently approved mRNA vaccines from Moderna and Pfizer-BioNTech help create neutralizing antibodies against the SARS-CoV-2 spike protein. Both companies designed their vaccines to be delivered in two doses. However, given the limited supply of vaccines worldwide, a new modeling study has suggested that vaccinating more people with the first dose and delaying the second could be an alternate route to achieving population immunity that could reduce mortality rates.

4 Mar 2021

Severe Acute Respiratory News and Research

Small negative lifestyle changes during COVID-19 lockdown could accumulate, say researchers

Novel bioinformatics tool could help improve COVID-19 diagnosis

How can physicians distinguish between COVID-19 persistence and SARS-CoV-2 reinfection?

Study analyzes COVID fatality rate using age and GDP as proxies for the quality and abundance of healthcare

Study confirms B.1.1.7 variant of SARS-CoV-2 is more transmissible

Saliva testing has high accuracy in detecting early cases of SARS-CoV-2

Children may transmit SARS-CoV-2 at same level as adults, suggests study

SARS-CoV-2 escapes host immune responses by modulating dendritic cell maturation

One dose of SARS-CoV-2 vaccine candidate boosts neutralizing antibody response in COVID-19 convalescents

A SARS-CoV-2 spike protein adjuvant vaccine candidate produces durable rapid protection in vivo

SARS-CoV-2 proteins are potent suppressors of innate immunity

Failing to communicate COVID-19 vaccine uncertainties has negative consequences

Preclinical study finds immune benefit in unrefrigerated Soligenix coronavirus vaccines

Study explains how the B.1.1.7 SARS-CoV-2 variant is more transmissible

Novavax COVID-19 vaccine shows efficacy against South African SARS-CoV-2 variant

Brazilian SARS-CoV-2 P.1 variant shows resistance to antibody neutralization

Combining terpenes and cannabidiol may be highly active against human coronaviruses

Study reveals a small molecule inhibits SARS-CoV-2 infection in cells

Delayed detection of oral fluid anti-SARS-CoV-2 antibodies increases the time to viral clearance

Researchers show potential benefits of delaying second mRNA COVID-19 vaccine dose

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