Signaling Pathway News and Research

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New model for signal transduction in cells

Among the key communication systems within a cell is the Wnt signaling pathway, which regulates embryonic development and whose deregulation can also contribute to cancer development.

28 Jun 2007

Scientists show protein accelerates breast cancer progression in animal models

The study is being published in an advanced online edition of the Proceedings of the National Academy of Sciences.

23 Jun 2007

PINK1 protects from Parkinson's

Parkinson disease (PD) is a common neurodegenerative disease characterized by the selective loss of midbrain dopaminergic neurons.

19 Jun 2007

New cellular pathway that operates to restrict inflammation and immunity

Jonsson Cancer Center have discovered a novel anti-inflammatory cell signaling pathway that may serve as a vital Yin-Yang mechanism to maintain the delicate balance of immune response.

16 Jun 2007

Mouse hibernation hormones described

A key hormone enables starving mice to alter their metabolism and “hibernate” to conserve energy, revealing a novel molecular target for drugs to treat human obesity and metabolic disorders, UT Southwestern Medical Center researchers have found.

8 Jun 2007

Check and balance for neuron activity provides insight into schizophrenia, seizures

Two genes important for human development and implicated in cancer and schizophrenia also help keep a healthy balance between excitation and inhibition of brain cells, researchers say.

24 May 2007

Clearer view of synaptic plasticity

Scientists are keenly studying how neurons form synapses--the physical and chemical connections between neurons--and the "pruning" of neural circuits during development, not least because synaptic abnormalities may partially underlie many developmental and neurodegenerative diseases.

17 May 2007

New understanding of ubiquitylation

It turns out there's more than one way to skin a gene. New research from Rockefeller University suggests that two closely related DNA unpackaging mechanisms may not work the way scientists thought.

10 May 2007

Biomira selects PX-866 as clinical development candidate

Biomira Inc. has announced that it has selected PX-866 as its next clinical development candidate.

17 Apr 2007

Study improves understanding of early ovarian cancer

A new University of Michigan Medical School study sheds light on cell defects that lead to one common type of ovarian cancer and puts forth a promising new mouse model that already is being used for preclinical drug testing.

12 Apr 2007

New mouse model for ovarian cancer

12 Apr 2007

Insulin receptors play a critical role in promoting islet growth

A new Joslin-led study has identified the insulin receptor as an important protein that promotes islet cell growth in mice whose bodies are unable to use insulin properly, or are insulin resistant, a precursor to type 2 diabetes.

4 Apr 2007

Fungal compound galiellalactone may combat prostate cancer

Can a substance from a fungus that grows on decaying trees provide a cure for aggressive prostate cancer? This is the hope of researchers at Lund University in Sweden.

3 Apr 2007

Inflammation plays key role in the metastasis of prostate cancer

Many would assume that "mounting an immune response" or "having your body fight the cancer" is a good thing.

19 Mar 2007

Scientists decipher a signaling pathway crucially involved in Crohn's disease and ulcerative colitis

Inflammatory bowel diseases, such as Crohn's disease and Ulcerative Colitis, severely impair the lives of more than four million people worldwide. The development of effective therapies against these diseases requires an understanding of their underlying molecular mechanisms.

15 Mar 2007

Genetic mutations make people susceptible to schizophrenia

Gene mutations governing a key brain enzyme make people susceptible to schizophrenia and may be targeted in future treatments for the psychiatric illness, according to MIT and Japanese researchers.

20 Feb 2007

Cell pathway identified which plays critical role in colon cancer

For the one in 18 men and women who will be diagnosed with cancer of the colon and rectum during their lifetime and over 150,000 people diagnosed on a yearly basis, today's genetic research news offers some optimism.

20 Feb 2007

TrkB and its role in learning and memory

For the first time researchers investigate the molecular basis of memory in living mice.

9 Jan 2007

Researchers create roadmap to integrin activation

Calling it an important technical advance in the study of the complex receptors and pathways of the body's cellular system, researchers at the University of California, San Diego (UCSD) School of Medicine have reconstructed the signaling pathways that impact activation of a receptor that is critical to the control of bleeding and to the thrombosis that occurs in heart attacks and strokes.

18 Sep 2006