Small Molecules News and Research

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A comprehensive rule book for the design of safe and efficient therapeutic cells

Therapies based on engineered immune cells have recently emerged as a promising approach in the treatment of cancer.

15 Apr 2022

Let’s Talk about Parkinson’s

In recognition of World Parkinson's Day, we speak to Dr. Arthur Roach, Director of Research at Parkinson’s UK, about the current Parkinson's landscape.

11 Apr 2022

Study explores broad-spectrum, host-acting antiviral strategy to treat SARS-CoV-2

A new study investigates the combination of two small molecules that target the host cells and reports a synergistic antiviral activity in vitro against SARS-CoV-2.

7 Apr 2022

Researchers discover a cell plasticity and inflammation driving druggable copper-signaling pathway

A new study identified mechanisms regulating immune cell plasticity to develop new therapeutics.

31 Mar 2022

New model reveals how antibodies navigate pathogen surfaces like a child at play

A new study shows how antibodies select the antigens that they bind to, as they navigate the surface of pathogens like coronaviruses.

24 Mar 2022

Posaconazole found to be effective as a small molecule fusion inhibitor against SARS-CoV-2 variants

Researchers evaluated the importance of the Ex3Lx6L motif in SARS-CoV-2 entry into host cells mediated by the spike protein syncytium formation and membrane fusion.

22 Mar 2022

Study unveils several natural marine products as potential agents against SARS-CoV-2

A recent study, published in the Journal of Natural Products of the American Chemical Society and American Society of Pharmacognosy, highlighted three natural marine products as potent inhibitors of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – without any apparent toxic effects for human lung cells.

21 Mar 2022

Yale researchers uncover how to control the blood-brain barrier with a molecule

The brain is composed of billions of neurons-; vulnerable cells that require a protective environment to function properly.

16 Mar 2022

Bioactive small molecules enhance CRISPR/Cas9 loss-of-function editing in human cells

Researchers demonstrate enhanced loss-of-function editing of CRISPR/Cas9 in human cells.

14 Mar 2022

In silico screening and testing of FDA approved drugs inhibiting SARS-CoV-2 spike protein cleavage

Researchers screened 5,000 Food and Drug Association-approved drugs to identify repurposed drugs targeting SARS-CoV-2 spike protein cleavage at both S1/S2 boundary and S2’.

11 Mar 2022

Study shows SARS-CoV-2 infection induces global alterations of the host endomembrane system

Researchers observed that Golgi fragmentation induced by SARS-CoV-2 facilitates viral trafficking.

11 Mar 2022

Researchers solve the structure of large signaling protein involved in emergence of blood cancers

Researchers led by Christopher Garcia of the Ludwig Center at Stanford University have solved the long-sought structure of a large signaling protein involved in responses to infection, inflammation, the generation of immune cells and when dysregulated by mutation-; the emergence of blood cancers known as myeloproliferative neoplasms.

11 Mar 2022

Small Molecules News and Research

A comprehensive rule book for the design of safe and efficient therapeutic cells

Let’s Talk about Parkinson’s

Study explores broad-spectrum, host-acting antiviral strategy to treat SARS-CoV-2

Researchers discover a cell plasticity and inflammation driving druggable copper-signaling pathway

New model reveals how antibodies navigate pathogen surfaces like a child at play

Posaconazole found to be effective as a small molecule fusion inhibitor against SARS-CoV-2 variants

Study unveils several natural marine products as potential agents against SARS-CoV-2

Yale researchers uncover how to control the blood-brain barrier with a molecule

Bioactive small molecules enhance CRISPR/Cas9 loss-of-function editing in human cells

In silico screening and testing of FDA approved drugs inhibiting SARS-CoV-2 spike protein cleavage

Study shows SARS-CoV-2 infection induces global alterations of the host endomembrane system

Researchers solve the structure of large signaling protein involved in emergence of blood cancers

A new view of SARS-CoV-2 genome structure

Scientists predict structure of SARS-CoV-2 frameshifting pseudoknot

Identification of compounds that inhibit SARS-CoV-2 Mac1-ADP-ribose binding

Integrity Bio and LakePharma Become Curia

Researchers reveal new therapeutic way to block oncogenic RAS mutants

UCLA researchers develop a smartwatch that assesses cortisol levels found in sweat

Damon Runyon Cancer Research Foundation announces newest cohort of Fellows and Breakthrough Scientists

SARS-CoV-2 virus co-opts intrinsic cellular machinery to suppress interferon production

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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