Small Molecules News and Research

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Revolutionizing drug discovery: Giga-scale screening unleashes power of AI and virtual libraries

Research discusses recent advances in computer-aided drug discovery, including the use of virtual screening and deep learning methods and their potential to revolutionize the drug discovery process by identifying diverse, potent, and drug-like ligands to protein targets.

28 Apr 2023

New strategy for identifying small molecules offers a promising path for discovering targeted drugs

Scripps Research scientists have developed a new strategy for identifying small molecules that can change the function of proteins, offering a promising path for discovering targeted drugs.

27 Apr 2023

Developing Next-Generation Nanomaterials for Medical Applications

In this interview conducted at Pittcon 2023 in Philadelphia, Pennsylvania, we spoke to Dr. Chad Merkin, Director of the International Institute for Nanotechnology, about his work developing next-generation nanomaterials for medical applications.

From Pittcon 27 Apr 2023

Study uncovers a protein-protein interaction that contributes to Parkinson's disease

In a study published in Nature Communications, a team led by Krembil Brain Institute Senior Scientists, Drs. Lorraine Kalia and Suneil Kalia, and University of Toronto (U of T) Professor, Dr. Philip M. Kim, identified a protein-protein interaction that contributes to Parkinson's disease.

20 Apr 2023

New drug could effectively disarm multidrug-resistant bacteria

A new type of drug could provide a way to treat multidrug-resistant bacteria, according to a study published in Nature Communications.

19 Apr 2023

Study uncovers a novel fold within the SARS-CoV-2 replication co-factor non-structural protein 9

Researchers present the crystal structure of an anti-non-structural protein 9 specific nanobody in complex with the SARS-CoV-2 nsp9.

15 Apr 2023

Genomic study reveals Babesia duncani's pathogenicity and virulence

'Tis the season for hiking now that spring has arrived and temperatures are on the upswing. But with hikes come insect bites and on the increase in North America is babesiosis, a malaria-like disease spread especially between May and October by a tick.

13 Apr 2023

MIP Discovery announces drugs of abuse reagent launch

MIP Discovery, a leader in rationally designed detection reagents based on its proprietary nanoMIP technology, in response to the growing synthetic opioid crisis has announced the launch of its first drugs of abuse products which are able to recognize norfentanyl, the main urinary metabolite of fentanyl.

From MIP Discovery 4 Apr 2023

Oral antiviral CD04872SC shows promise in neutralizing COVID-19 variants, offering hope for broad-spectrum treatment

Researchers discover a small molecule drug candidate that could provide immediate protection against infection with SARS-CoV-2.

4 Apr 2023

Lipid Nanoparticles (LNPs) and DNA delivery – unlocking the future of medical research

In this interview, Kate Stumpo speaks to Michael Girgis about Lipid nano particles, and the future of the field.

From Bruker Life Sciences Mass Spectrometry 31 Mar 2023

New insights and emerging disease-modifying drugs for Alzheimer’s disease treatment

A recent review published in Biochemical Pharmacology summarized the ongoing research, providing insights into pathophysiology and emerging drugs for Alzheimer’s disease (AD).

31 Mar 2023

Riboswitch may be the key to advance gene therapy, regenerative medicine

The Okinawa Institute of Science and Technology, in collaboration with Astellas Pharma Inc., has developed a new toolkit that uses small molecules to control the activity of a piece of synthetic RNA, and ultimately regulate gene expression.

30 Mar 2023

New review examines link between HDLC and different types of cancer

Researchers summarized studies on the association between high-density lipoprotein cholesterol and different types of cancer

29 Mar 2023

Discovery suggests a new way to treat spinal muscular atrophy

Columbia researchers have discovered how a genetic defect leads to spinal muscular atrophy (SMA), a critical piece of information about the disease that neurologists have been seeking for decades.

23 Mar 2023

Next-gen Mpro inhibitor: Promising new drug candidate against Omicron and other SARS-CoV-2 variants

A recent Nature Signal Transduction and Targeted Therapy journal study demonstrated the potential antiviral activity of a new Mpro inhibitor (SY110) against SARS-CoV-2 Omicron and its sublineages.

21 Mar 2023

Snapping at new biotech breakthroughs with Gator Pro

In this interview, we speak to Subodh Nimkar, Marketing Director at Gator Bio, about their latest technology, Gator Pro which allows for fast, reliable, and high-quality data.

From Gator Bio, Inc. 21 Mar 2023

AI-based design method synthesizes polymers that mimic blood plasma

Most life on Earth is based on polymers of 20 amino acids that have evolved into hundreds of thousands of different, highly specialized proteins. They catalyze reactions, form backbone and muscle and even generate movement.

20 Mar 2023

Newly identified small molecule may help treat people with drug-resistant epilepsy

Researchers at Tufts University School of Medicine and colleagues have identified a small molecule that may help treat people with epilepsy whose condition has become resistant to the benzodiazepine drugs usually used in managing seizures.

15 Mar 2023

Specific enzyme produced in liver cancer cells could turn a molecule into potential anticancer drug

Scientists at the National Institutes of Health and Massachusetts General Hospital in Boston have uncovered a potential new approach against liver cancer that could lead to the development of a new class of anticancer drugs.

14 Mar 2023

Novel culture system for effectively growing large numbers of blood stem cells in the lab

Hematopoietic stem cells (HSCs) are important immature blood cells in bone marrow that can be triggered to develop into any blood cell type.

8 Mar 2023