Smallpox News and Research

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Smallpox is a highly contagious disease caused by the variola virus, a member of the Orthopox virus family. It is one of the most devastating diseases known to humanity, with a mortality rate as high as 30%. In 1967, the World Health Organization embarked upon an intensified vaccination campaign to eliminate smallpox, which culminated in the successful eradication of the disease globally by 1980.

By the mid-1980s, there were only two known repositories of variola virus: the Institute of Virus Preparations in Russia, and the US CDC. The events in the US in September and October 2001 highlighted the risk that the variola virus might be used as an agent of bioterrorism. Governments around the world are taking precautionary measures to be ready to deal with a potential smallpox outbreak.

Breakthrough could help protect against the use of smallpox by terrorists

Researchers at the ANU John Curtin School of Medical Research have identified proteins that determine which mice succumb to mousepox and which do not. The new insights into the immune response of mice to the mousepox virus could enable scientists to improve treatment for poxvirus infections, including smallpox.

9 Jun 2004

150 top scientists debate and offer expert advice on cutting edge vaccine research

More than 150 top scientists, researchers and public health experts from around the world will meet in Switzerland next week to present, debate and offer expert advice on cutting edge vaccine research and development, as well as vaccine policy and implementation.

3 Jun 2004

Myth of disease threat posed by dead bodies after natural disasters unfounded

Fears that dead bodies will spread infection and disease following natural disasters are largely baseless, and simply serve to prolong the suffering of surviving friends and family members, according a scientific article published today.

1 Jun 2004

Double-punch approach to vaccine design more effective

A study revealing new information about how viral proteins move between cells and alert the immune system suggests that a double-punch approach to vaccine design would make them more effective.

1 Jun 2004

Research tests the efficacy of a smallpox vaccine candidate known as LC16m8

When used as an aerosolized weapon, smallpox could be controlled by a new vaccine under study at Saint Louis University School of Medicine, according to new data.

27 May 2004

$3.5 million grant to develop AIDS vaccinations

Researchers at the Vaccine and Gene Therapy Institute (VGTI) and the Oregon National Primate Research Center at Oregon Health & Science University have received a $3.5 million grant from the National Institutes of Health to develop new methods for vaccinating humans against human immunodeficiency virus (HIV), the virus that causes AIDS.

25 May 2004

WHO to tackle heart disease, diabetes, cancers, road safety as well as diseases

The World Health Assembly, the supreme decision-making body of the World Health Organization, has raised global public health to a new level, by resolving to take more action to prevent death and illness resulting from heart disease, diabetes, cancers, road safety, and lack of access to health services as well as from diseases spread by viruses, bacteria and other dangerous microbes.

22 May 2004

Network formed to tackle potentially fatal reaction to smallpox vaccine

The National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH), launched the Atopic Dermatitis and Vaccinia Network (ADVN), a nationwide research group that seeks to reduce the risk of eczema vaccinatum (EV), a severe and potentially deadly complication of smallpox immunization.

19 May 2004

$20.7 million to make smallpox vaccine safer

The National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health, has awarded a five-year, $20.7 million grant to National Jewish Medical and Research Center to lead a consortium of academic medical centers trying to make smallpox vaccines safer for millions of people with atopic dermatitis, also known as eczema.

19 May 2004

Higher rate of cardiac complications from smallpox vaccinations for US military

While adverse reactions from smallpox vaccinations given to military personnel in the wake of renewed threats of bioterrorism remain minimal, the rate of cardiac complications has been higher than expected, according to a clinical review presented at an American Medical Society media briefing on cardiology today.

16 May 2004

Alternative vaccine to Dryvax for smallpox

Not everybody can safely be vaccinated against smallpox using the current FDA-approved vaccine. Scientists hope another study vaccine, now undergoing its first testing in the United States at Saint Louis University, will give a choice to people who can't be given the current vaccine, known as Dryvax®.

10 May 2004

Experts conclude plans to control zoonoses, diseases transmitted from animals to humans

International experts today concluded a three-day international consultation on zoonoses, held by the World Health Organization (WHO) together with the Food and Agriculture Organization (FAO) and the World Organization for Animal Health (OIE), in collaboration with the Dutch Health Council.

6 May 2004

Computers to combat disease

A new initiative harnesses the USA's computing skill to enhance our ability to respond to disease epidemics and bioterrorism.

4 May 2004

Scientists looking for 480 people to test experimental anthrax vaccine

Scientists in Rochester and 11 other cities around the nation are beginning tests of an experimental vaccine aimed at protecting people against anthrax, a rare disease that, like smallpox, has become more threatening with the emergence of bioterrorism.

28 Apr 2004

Experimental smallpox DNA vaccine

In the first successful study of its kind, scientists have shown that a DNA-based vaccine for smallpox can protect nonhuman primates from monkeypox, a disease that resembles smallpox in humans.

27 Apr 2004

World expert speaks on bioterrorism and emerging infections

World renowned and esteemed Australian virologist Professor Frank Fenner will present the inaugural Rod Andrew Oration this week at Monash University. His topic "Big lessons from smallpox: bioterrorism and emerging infections" is timely and sure to be thought-provoking.

19 Apr 2004

An experimental vaccine based on a critical piece of the SARS virus

An experimental vaccine based on a critical piece of the SARS virus protects mice from SARS infection, researchers from the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, have found.

19 Apr 2004

Scientists studying vaccinia virus, a relative of smallpox, have determined that a gene necessary for virus replication also has a key role in turning off inflammation

Scientists at the University of Illinois at Urbana-Champaign studying vaccinia virus, a close relative of smallpox, have determined that a gene necessary for virus replication also has a key role in turning off inflammation, a crucial anti-viral immune response of host cells.

6 Apr 2004

First US Tests of Bird-Flu Vaccine in Humans

Doctors are beginning the first test in the United States of a vaccine designed to protect people against one form of bird flu should an outbreak of the virus occur in humans. While the vaccine under study is not designed to protect against the precise bird-flu virus causing the current outbreak in poultry and in people, scientists will learn whether it protects against another strain of the virus that infects birds and people.

24 Mar 2004