Spike Protein News and Research

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Cholesterol in the plasma membrane is essential for SARS-CoV-2 entry and syncytia formation

A preprint indicates that SARS-CoV-2 requires cholesterol to accomplish entry into the host cells and membrane fusion.

17 Dec 2020

Gene surfing caused the SARS-CoV-2 D614G variant to rise to dominance in the US

A recent preprint that appeared on the bioRxiv* server applies a new approach to conventional birth-death lineage modeling.

17 Dec 2020

SARS-CoV-2 spike deletion ΔH69/ΔV70 shows repeated emergence and spread

Since the COVID 19 pandemic, it has been established that the causative virus, SARS-CoV-2 gains entry to the target host cell via its spike glycoprotein.

17 Dec 2020

HDL nanoparticles prevent cholesterol movement at membrane receptor to inhibit entry of SARS-CoV-2 pseudovirus in cell culture

As researchers strive to find safe therapeutics for COVID 19, a study suggests that preventing the movement of cholesterol may inhibit viral entry by up to 80%.

17 Dec 2020

Why are some groups more vulnerable to COVID-19?

News-Medical speaks to Dr. Jaswinder Singh about his research surrounding why some groups are more susceptible to severe cases of COVID-19.

17 Dec 2020

Traditional herbal medicine Respiratory Detox Shot (RDS) inhibits SARS-CoV, SARS-CoV-2 and Influenza A infection in vitro

As researchers continue to search for antivirals to counter COVID-19, a study presents the potential utility of a decoction called Respiratory Detox Shot (RDS).

16 Dec 2020

Autoimmune condition biomarkers promote SARS-CoV-2 viral entry, study finds

Researchers have reported that the autoimmune PTPN2 risk variant rs1893217 promotes the expression of the SARS-CoV-2 receptor, ACE2, and thus promotes cellular entry, which is mediated by SARS-CoV-2 spike S protein.

16 Dec 2020

AI-based study of social media maps SARS-CoV-2 vaccine hesitancy across the US

Researchers from the University of Rochester, USA, has produced an AI-based study that analyzes the social media platform Twitter to gauge public opinions in the US surrounding SARS-CoV-2 vaccines to shed greater light on this issue.

15 Dec 2020

Researchers develop new technology for efficient production of monoclonal antibodies

Proteins in biopharmaceutical productions are usually separated and purificated through the expensive chromatography technique. European researchers are developing an innovative membrane crystallization technology to overcome the issue and make the production of monoclonal antibodies more efficient.

15 Dec 2020

UK government declares identification of a “new variant” of coronavirus

The UK government has released a statement that a “new variant” of coronavirus that could be causing a faster spread of the virus has been identified.

15 Dec 2020

Reliable Antibodies Testing for SARS-CoV-2

In this interview, Poncho Meisenheimer, VP of R&D at Promega, talks to News-Medical Life Sciences about the importance of having the reliability for SARS-Co-V-2 antibody tests.

From Promega Corporation 15 Dec 2020

Eureka's InvisiMask human antibody nasal spray offers protection against SARS-CoV-2 in mice

Eureka Therapeutics, Inc. announced today successful preclinical results from its InvisiMask™ Human Antibody Nasal Spray in mice, which offers protection against SARS-CoV-2 S pseudotyped virus infection for up to 10 hours.

14 Dec 2020

Remdesivir likely to be highly effective treatment for COVID-19

The drug remdesivir is likely to be a highly effective antiviral against SARS-CoV-2, according to a new study by a team of UK scientists.

14 Dec 2020

Researchers test commercial assays to detect SARS-CoV-2 antibodies six months after infection

Researchers at the Hospices Civils de Lyon (HCL) in France found that people infected with SARS-CoV-2 can develop antibodies that persist for up to six months. After testing commercial assays to detect antibodies, the Wantai antibody assay has a positivity rate of 100%.

14 Dec 2020

Emergence of resistant SARS-CoV-2 variant in immunocompromised patient following therapeutic antibody use

The focus is increasingly moving towards vaccine roll-out as the world faces the real possibility of the second year of social and economic restrictions.

14 Dec 2020

Prior T cell immunity to SARS-CoV-2 unlikely to be the result of seasonal coronavirus infection

Scientists have suggested that a proportion of the population have pre-existing immunity to COVID-19 because of T cells primed against SARS-CoV-2 antigens.

14 Dec 2020

D614G mutation promotes lysosomal trafficking of SARS-CoV-2 spike protein

In the current COVID-19 pandemic, SARS-CoV-2 has led to millions of infections worldwide, with over 1.5 million deaths.

14 Dec 2020

RNA editing within host linked to SARS-CoV-2 variants

Since the start of the COVID-19 pandemic, the causative virus, SARS-CoV-2, has undergone several mutations.

14 Dec 2020

Distant residues modulate the conformational opening in SARS-CoV-2 spike protein

Scientists present an insight into the RBD dynamics with physically distant residues in the spike protein, elaborating on the importance of predicted mutations for therapeutics.

11 Dec 2020

Study shows how coronavirus uses spike proteins to infiltrate cells of different animals

Humans, followed by ferrets and to a lesser extent cats, civets and dogs are the most susceptible animals to SARS-CoV-2 infection, according to an analysis of ten different species carried out by researchers at the Centre for Genomic Regulation (CRG), based in Barcelona.

11 Dec 2020

Spike Protein News and Research

Cholesterol in the plasma membrane is essential for SARS-CoV-2 entry and syncytia formation

Gene surfing caused the SARS-CoV-2 D614G variant to rise to dominance in the US

SARS-CoV-2 spike deletion ΔH69/ΔV70 shows repeated emergence and spread

HDL nanoparticles prevent cholesterol movement at membrane receptor to inhibit entry of SARS-CoV-2 pseudovirus in cell culture

Why are some groups more vulnerable to COVID-19?

Traditional herbal medicine Respiratory Detox Shot (RDS) inhibits SARS-CoV, SARS-CoV-2 and Influenza A infection in vitro

Autoimmune condition biomarkers promote SARS-CoV-2 viral entry, study finds

AI-based study of social media maps SARS-CoV-2 vaccine hesitancy across the US

Researchers develop new technology for efficient production of monoclonal antibodies

UK government declares identification of a “new variant” of coronavirus

Reliable Antibodies Testing for SARS-CoV-2

Eureka's InvisiMask human antibody nasal spray offers protection against SARS-CoV-2 in mice

Remdesivir likely to be highly effective treatment for COVID-19

Researchers test commercial assays to detect SARS-CoV-2 antibodies six months after infection

Emergence of resistant SARS-CoV-2 variant in immunocompromised patient following therapeutic antibody use

Prior T cell immunity to SARS-CoV-2 unlikely to be the result of seasonal coronavirus infection

D614G mutation promotes lysosomal trafficking of SARS-CoV-2 spike protein

RNA editing within host linked to SARS-CoV-2 variants

Distant residues modulate the conformational opening in SARS-CoV-2 spike protein

Study shows how coronavirus uses spike proteins to infiltrate cells of different animals

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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