Spleen News and Research

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Tobacco mosaic virus nanoparticle-based novel COVID-19 vaccine candidate

Scientists generate a VLP type NP platform made of recombinant viral antigens conjugated with TMV virions.

23 Nov 2021

Researchers discover new type of cell that may help regulate heart rate

Researchers at the University of Notre Dame discovered a new type of cell in the heart that may help regulate heart rate, and could be an important key in understanding certain types of congenital heart defects and other diseases that involve the heart.

21 Nov 2021

Study reveals complex interplay between diet, gut microbiota, and immune function

The cliché "you are what you eat" has been used for hundreds of years to illustrate the link between diet and health. Now, an international team of researchers has found the molecular proof of this concept, demonstrating how diet ultimately affects immunity through the gut microbiome.

17 Nov 2021

A study of livestock exposure to the SARS-CoV-2 virus

Researchers recently published reports on pilot studies evaluating the susceptibility of common domestic livestock (cattle, sheep, goat, alpaca, rabbit, and horse) to intranasal infection with SARS-CoV-2 in the journal Emerging Microbes & Infections.

14 Nov 2021

Mycobacterium tuberculosis may induce resistance to secondary SARS-CoV-2 infection

The current study reveals that mice infected with mycobacterium tuberculosis are resistant to SARS-CoV-2 infection.

14 Nov 2021

Study improves understanding of the link between obesity and gum disease

Chronic inflammation caused by obesity may trigger the development of cells that break down bone tissue, including the bone that holds teeth in place, according to new University at Buffalo research that sought to improve understanding of the connection between obesity and gum disease.

12 Nov 2021

Researchers identify gene expression involved in cancer progression and chemotherapy resistance

Even within a single patient with cancer, there is a vast diversity of individual tumor cells, which display distinct behaviors related to growth, metastasis, and responses to chemotherapy.

11 Nov 2021

Researchers investigate how intestinal bacteria distribute metabolic products in membrane vesicles

Bacteria in the intestine pack a wide spectrum of their biomolecules into small capsules. These are transported via the bloodstream to various organs in the body and even absorbed and processed by nerve cells in the brain.

9 Nov 2021

Study finds inhaled microspheres reduce SARS-CoV-2 infective effectiveness

A new study develops an inhaled microfluidic microsphere with a genetically engineered membrane from the ACE2 receptor-overexpressing cells and macrophages.

1 Nov 2021

Electroceutical research with widespread implications for regulating spleen function

An international team of researchers, led by University of Houston Cullen Endowed Professor of biomedical engineering Mario Romero-Ortega, has progressed electroceutical research for treatment of diseases including rheumatoid arthritis, colitis and sepsis.

25 Oct 2021

Improper Z-RNA recognition contributes to pathogenesis of Aicardi-Goutières syndrome

Like DNA, RNA molecules contain information through unique combinations of four different nucleotides. However, through a molecular process called RNA editing, chemical changes can be made to adenosine nucleotides that convert them to a nucleotide called inosine by enzymes known as adenosine deaminases (ADARs).

21 Oct 2021

SARS-CoV-2 induces tissue immune memory

A new study reports that the SARS-CoV-2 induces protective tissue memory that includes both humoral and cellular elements to protect specific tissue sites.

14 Oct 2021

Hollings Cancer Center researcher awarded NCI grant to pursue early investigator studies in leukemia

MUSC Hollings Cancer Center researcher Haizhen (Jen) Wang, Ph.D., was awarded a five-year $344,000 per year grant by the National Cancer Institute to pursue her early investigator studies in leukemia.

5 Oct 2021

Review explores the role of cellular senescence in lymphoid organ dysfunction and immunosenescence

Aging-US published "Cellular senescence in lymphoid organs and immunosenescence" which reported that immunosenescence is a multi-faceted phenomenon at the root of age-associated immune dysfunction.

5 Oct 2021

Study paves the way for development of novel delivery systems to suppress HIV

In a new study supported by the National Institutes of Health, researchers used exosomes, tiny nanoparticles capable of being taken up by cells, to deliver novel protein into the cells of mice infected with HIV. The protein attached to HIVs' genetic material and prevented it from replicating, resulting in reduced levels of HIV in the bone marrow, spleen, and brain.

21 Sep 2021

Specially designed lipid nanoparticles overcome resistance to anti-tumor immunotherapy

A specially designed lipid nanoparticle could deliver immune-signaling molecules into liver macrophage cells to overcome resistance to anti-tumor immunotherapy.

18 Sep 2021

Scientists identify new approach to overcome resistance to cancer immunotherapy

Hokkaido University scientists and colleagues in Japan have found a way that could help some patients overcome resistance to immunotherapy treatment for cancer. The approach, proven in mice experiments, was reported in the Journal for Immunotherapy of Cancer.

17 Sep 2021