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Lung memory B-cells provide primary protection against SARS-CoV-2 reinfection

Researchers study influenza and SARS-CoV-2 infection models to identify lung memory B cells during viral infection.

20 Dec 2021

Using fungal vaccine to train stem cells and enhance immune response to infections

The research group Immunology of Fungal Infections at the University of Valencia (UV) has investigated a fungal vaccine with which to train stem cells and hematopoietic progenitors (which produce all the cells of the blood and lifelong immune system) to improve the immune response to infections. The work has been published in the journal Frontiers in Immunology.

16 Dec 2021

New mRNA vaccine platform provides stronger protection against SARS-CoV-2 delta variant

A group of researchers from various institutions developed a nucleoside-modified mRNA vaccine that encodes the SARS-CoV-2 N protein (mRNA-N) and is formulated in lipid nanoparticles for this investigation (LNP).

14 Dec 2021

Novel therapy found to be safe and well-tolerated in patients with bone marrow cancer

Mount Sinai physician-scientists have found that a novel therapy for the bone marrow cancer myelofibrosis is safe and well-tolerated and is associated with modest improvements in patients in a Phase 1b clinical trial.

12 Dec 2021

Scientists develop and characterize variant-specific vaccines against SARS-CoV-2

In a recent study conducted at Yale University, USA, scientists have investigated the immunogenicity of mRNA-based coronavirus disease 2019 (COVID-19) vaccine candidates encoding the spike proteins of different severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants. The findings reveal that the vaccines induce robust immune responses against SARS-CoV-2 variants. The study is currently available on the bioRxiv* preprint server.

6 Dec 2021

NEI researchers identify unique population of B cells that tamps down the immune system

Researchers at the National Eye Institute (NEI) have identified, isolated, and characterized a unique population of B cells that tamps down the immune system, reducing chronic inflammation.

2 Dec 2021

Tobacco mosaic virus nanoparticle-based novel COVID-19 vaccine candidate

Scientists generate a VLP type NP platform made of recombinant viral antigens conjugated with TMV virions.

23 Nov 2021

Researchers discover new type of cell that may help regulate heart rate

Researchers at the University of Notre Dame discovered a new type of cell in the heart that may help regulate heart rate, and could be an important key in understanding certain types of congenital heart defects and other diseases that involve the heart.

21 Nov 2021

Study reveals complex interplay between diet, gut microbiota, and immune function

The cliché "you are what you eat" has been used for hundreds of years to illustrate the link between diet and health. Now, an international team of researchers has found the molecular proof of this concept, demonstrating how diet ultimately affects immunity through the gut microbiome.

17 Nov 2021

A study of livestock exposure to the SARS-CoV-2 virus

Researchers recently published reports on pilot studies evaluating the susceptibility of common domestic livestock (cattle, sheep, goat, alpaca, rabbit, and horse) to intranasal infection with SARS-CoV-2 in the journal Emerging Microbes & Infections.

14 Nov 2021

Mycobacterium tuberculosis may induce resistance to secondary SARS-CoV-2 infection

The current study reveals that mice infected with mycobacterium tuberculosis are resistant to SARS-CoV-2 infection.

14 Nov 2021

Study improves understanding of the link between obesity and gum disease

Chronic inflammation caused by obesity may trigger the development of cells that break down bone tissue, including the bone that holds teeth in place, according to new University at Buffalo research that sought to improve understanding of the connection between obesity and gum disease.

12 Nov 2021

Researchers identify gene expression involved in cancer progression and chemotherapy resistance

Even within a single patient with cancer, there is a vast diversity of individual tumor cells, which display distinct behaviors related to growth, metastasis, and responses to chemotherapy.

11 Nov 2021

Researchers investigate how intestinal bacteria distribute metabolic products in membrane vesicles

Bacteria in the intestine pack a wide spectrum of their biomolecules into small capsules. These are transported via the bloodstream to various organs in the body and even absorbed and processed by nerve cells in the brain.

9 Nov 2021

Study finds inhaled microspheres reduce SARS-CoV-2 infective effectiveness

A new study develops an inhaled microfluidic microsphere with a genetically engineered membrane from the ACE2 receptor-overexpressing cells and macrophages.

1 Nov 2021

Electroceutical research with widespread implications for regulating spleen function

An international team of researchers, led by University of Houston Cullen Endowed Professor of biomedical engineering Mario Romero-Ortega, has progressed electroceutical research for treatment of diseases including rheumatoid arthritis, colitis and sepsis.

25 Oct 2021

Improper Z-RNA recognition contributes to pathogenesis of Aicardi-Goutières syndrome

Like DNA, RNA molecules contain information through unique combinations of four different nucleotides. However, through a molecular process called RNA editing, chemical changes can be made to adenosine nucleotides that convert them to a nucleotide called inosine by enzymes known as adenosine deaminases (ADARs).

21 Oct 2021

Spleen News and Research

Lung memory B-cells provide primary protection against SARS-CoV-2 reinfection

Using fungal vaccine to train stem cells and enhance immune response to infections

New mRNA vaccine platform provides stronger protection against SARS-CoV-2 delta variant

Novel therapy found to be safe and well-tolerated in patients with bone marrow cancer

Scientists develop and characterize variant-specific vaccines against SARS-CoV-2

NEI researchers identify unique population of B cells that tamps down the immune system

Tobacco mosaic virus nanoparticle-based novel COVID-19 vaccine candidate

Researchers discover new type of cell that may help regulate heart rate

Study reveals complex interplay between diet, gut microbiota, and immune function

A study of livestock exposure to the SARS-CoV-2 virus

Mycobacterium tuberculosis may induce resistance to secondary SARS-CoV-2 infection

Study improves understanding of the link between obesity and gum disease

Researchers identify gene expression involved in cancer progression and chemotherapy resistance

Researchers investigate how intestinal bacteria distribute metabolic products in membrane vesicles

Study finds inhaled microspheres reduce SARS-CoV-2 infective effectiveness

Electroceutical research with widespread implications for regulating spleen function

Improper Z-RNA recognition contributes to pathogenesis of Aicardi-Goutières syndrome

SARS-CoV-2 induces tissue immune memory

Hollings Cancer Center researcher awarded NCI grant to pursue early investigator studies in leukemia

Review explores the role of cellular senescence in lymphoid organ dysfunction and immunosenescence

Snapping at new biotech breakthroughs with Gator Pro

Realizing the Importance of Medical Electronic Devices

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