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Investigational drug may help increase protein levels in babies with spinal muscular atrophy

A preliminary study suggests that an investigational drug may help increase protein levels in babies with spinal muscular atrophy. The open-label study is released today and will be presented at the American Academy of Neurology's 70th Annual Meeting in Los Angeles, April 21 to 27, 2018.

19 Apr 2018

CNIO researchers determine structure of protein complex related to cell survival

A team from the Spanish National Cancer Research Centre has determined for the first time the high-resolution structure of a complex (R2TP) involved in key processes for cell survival and in diseases such as cancer.

16 Apr 2018

UT Southwestern's Dr. Nijhawan selected for ASCI's 2018 Seldin-Smith Award

UT Southwestern's Dr. Deepak Nijhawan became a co-recipient of the 2018 Donald Seldin-Holly Smith Award for Pioneering Research. The award recognizes Dr. Nijhawan's work identifying targets for cancer treatment.

10 Apr 2018

Scientists discover basic molecular mechanism that helps understand how ALS works

It took eight long years of research, but now an international team led by neuroscientists at Université de Montréal has discovered a basic molecular mechanism that better helps understand how Lou Gehrig's disease, or amyotrophic lateral sclerosis (ALS), works.

19 Mar 2018

Discovery aids understanding of amyotrophic lateral sclerosis

Researchers have discovered a basic molecular mechanism that sheds light on the disease process underlying amyotrophic lateral sclerosis (ALS).

19 Mar 2018

Researchers develop method to identify splicing-based biomarkers for liver cancer

Because liver cancer is particularly diverse, genetically, and prone to relapse, identifying biomarkers that can predict disease progression is a critical goal in the fight against it.

2 Mar 2018

Study unravels developmental splicing program that promotes neuronal maturation

Neurons, or nerve cells, in the brain communicate with each other by transmitting electric signals, or firing action potentials, through long processes named axons (which send out signals) and dendrites (which receive signals).

1 Feb 2018

Why Should We Weigh Every Protein in the Human Body?

Our mission is to advance the measurement of human proteins with greater precision, to bring to the world the benefits of absolute molecular specificity when it comes to interrogating proteins at the molecular level.

From Pittcon 5 Jan 2018

Research clarifies role of zinc transport mechanism in onset of obstructive pulmonary diseases

Obstructive pulmonary disease is a collective term for refractory respiratory diseases with chronic airway inflammation and excessive mucus retention that are accompanied by airway obstruction.

28 Dec 2017

Loss of specific protein makes breast cancers more aggressive, resistant to chemotherapy

Researchers in Italy have discovered how specific versions of a protein called Numb protect the key tumor suppressor p53 from destruction.

21 Dec 2017

Caris Life Sciences reveals identification of new mechanism of action to treat NHL

Caris Life Sciences, a leading innovator in molecular science focused on fulfilling the promise of precision medicine, today announced a data presentation, at the 59th American Society of Hematology Annual Meeting & Exposition in Atlanta, demonstrating the identification of a new mechanism of action to treat non-Hodgkin lymphoma (NHL).

13 Dec 2017

Researchers reveal pathological mechanisms in congenital myotonic dystrophy

Myotonic dystrophy (DM) is the most common form of genetic muscular dystrophy that begins in adulthood. DM is characterized by progressive muscle wasting and weakness. People with this disorder often have prolonged muscle contractions (myotonic) and are not able to relax certain muscles after use.

12 Dec 2017

UC San Diego researchers receive nearly $8 million grant for new stem cell-based AML treatments

The Independent Citizens Oversight Committee of the California Institute for Regenerative Medicine unanimously approved yesterday two grants worth a total of almost $8 million to University of California San Diego School of Medicine researchers investigating novel stem cell-based treatments for acute myeloid leukemia or AML.

4 Dec 2017

Biogen and Ionis awarded 2017 Prix Galien USA Award for SPINRAZA

Biogen and Ionis have been awarded the prestigious 2017 Prix Galien USA Award for Best Biotechnology Product for SPINRAZA (nusinersen). The Prix Galien USA Award recognizes extraordinary achievement in scientific innovation that improves the state of human health. The award was presented at a ceremony in New York City on October 26, 2017.

30 Oct 2017

Penn study sheds light on genetic cause of early hearing loss

From the moment a baby is born, they are put through a battery of screenings to test for all sorts of characteristics, which includes the sense of hearing.

26 Oct 2017

Biochemists discover genes that determine animal complexity

Genes which determine animal complexity – or what makes humans so much more complex than a fruit fly or a sea urchin – have been identified for the first time.

30 Sep 2017

Alternative splicing may also trigger cancer, study shows

Cancer, which is one of the leading causes of death worldwide, arises from the disruption of essential mechanisms of the normal cell life cycle, such as replication control, DNA repair and cell death.

22 Sep 2017

Boise State professor wins federal grant to explore basic functions of the genome

It's rare for a faculty member in any physics department to earn a federal grant administered by the National Institutes of Health, but that is exactly what Boise State assistant professor and biophysicist Matt Ferguson has done.

14 Sep 2017

MUSC researchers show how non-coding RNA promotes tumor formation

A mechanism that pushes a certain gene to produce a non-coding form of RNA instead of its protein-coding alternative can promote the growth of cancer, report researchers at the Medical University of South Carolina in an article published online ahead of print on August 21, 2017 by Nature Cell Biology.

22 Aug 2017

Protein changes essential for normal adult muscle function

Researchers at Baylor College of Medicine have shed light on the process that guides the maturation of newborn muscles into adult, fully functional organs.

14 Aug 2017