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Study uncovers new markers present on melanoma tumors

A collaborative study led by Monash University's Biomedicine Discovery Institute and the Olivia Newton-John Cancer Research Institute has uncovered new markers (HLA-associated peptides) that are uniquely present on melanoma tumours and could pave the way for therapeutic vaccines to be developed in the fight against melanoma.

16 Sep 2020

Scientists unlock crucial molecular details regarding tau's activity

Frontotemporal lobar degeneration (FTLD) is a type of dementia that appears earlier in life than Alzheimer's disease (AD).

15 Sep 2020

Scientists elucidate cause for Parkinson's disease and identify potential treatments

In a seven-year research effort, an international team of scientists has clarified the cause for certain genetic forms of Parkinson's disease, and has identified potential pharmacological treatments.

12 Sep 2020

Acne drug could be a potential treatment for dilated cardiomyopathy

Dilated cardiomyopathy (DCM) is a leading cause of heart failure, affecting 1 in 250 people. The disease is characterised by an increase in size of the left ventricle of the heart.

8 Sep 2020

RNA-based therapeutic approach holds promise as potential cure for hereditary diseases

ETH Zurich scientists have developed an RNA molecule that can be used in bone marrow cells to correct genetic errors that affect protein production.

18 Aug 2020

Researchers identify new mechanism that causes leukemia

Every year, 1.1 million new cases of blood cancers are diagnosed worldwide. Presently, chemotherapy remains the most common and effective course of treatment.

13 Aug 2020

FDA approves first oral drug for treatment of spinal muscular atrophy

The U.S. Food and Drug Administration today approved Evrysdi (risdiplam) to treat patients two months of age and older with spinal muscular atrophy (SMA), a rare and often fatal genetic disease affecting muscle strength and movement.

7 Aug 2020

Unique molecular mechanics can pave way for potential treatments for infections

Unique molecular mechanics allowing parasites to thrive in the guts of one billion people open the door to new treatments that are safe for the host.

6 Aug 2020

New method reveals the dynamics of cell development and gene activity

Traditional single-cell sequencing methods help to reveal insights about cellular differences and functions - but they do this with static snapshots only rather than time-lapse films.

4 Aug 2020

UC San Diego researchers part of special package of human genome studies

Researchers at University of California San Diego School of Medicine are among the contributors to a package of 10 studies, published July 29, 2020 in the journal Nature, describing the latest results from the ongoing Encyclopedia of DNA Elements (ENCODE) project, a worldwide effort led by the National Institutes of Health to understand how the human genome functions.

29 Jul 2020

Continuous survival of neurons is intrinsically programmed during development

When our neurons -- the principle cells of the brain -- die, so do we.Most neurons are created during embryonic development and have no "backup" after birth. Researchers have generally believed that their survival is determined nearly extrinsically, or by outside forces, such as the tissues and cells that neurons supply with nerve cells.

25 Jul 2020

New regulatory mechanism reveals complex intricacies of plant immune responses

To ensure survival, living organisms are equipped with defensive systems that detect threats and respond with effective counter measures.

23 Jul 2020

RNA editing may repair the underlying cause of Rett Syndrome in mouse model

A genomic error that causes Rett Syndrome, a serious lifelong neurological disorder, can be corrected in the brains of mice by rewriting the genetic instructions carried by the RNA.

15 Jul 2020

Damon Runyon Cancer Research Foundation awards $3.2 million to early-career physician-scientists

The Damon Runyon Cancer Research Foundation has named four new Damon Runyon Clinical Investigators.

12 Jun 2020

Study unravels role of a protein in osteoclast generation

Bone-dissolving cells called osteoclasts are derived from a type of immune cells called macrophages. They are necessary for the maintenance and renewal of bones.

9 Jun 2020

Researchers shed new light on the structure of RNA

Australian and US researchers have made a breakthrough in understanding the structure of a key genetic molecule, called RNA, and revealing for the first time how these changes impact RNA's function.

7 May 2020

Study finds abnormal alternative RNA splicing patterns in aggressive prostate cancer

Aggressive forms of prostate cancer don't act the way they should, hanging on to genetic materials called introns that should be thrown away, a new six-year study led by Dean Tang, Ph.D., and Song Liu, Ph.D., of Roswell Park Comprehensive Cancer Center has revealed.

30 Apr 2020

Coronaviruses represent a source of pandemic viruses

In a new paper published on the preprint journal bioRxiv in April 2020, researcher T. Konishi argues that the coronavirus family is a constellation of pandemic pathogens, that includes the currently spreading severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

29 Apr 2020

Researchers develop online resource to refine results from RNA sequencing

DNA sequencing is becoming a more commonplace method for detecting diseases and improving precision medicine.

8 Apr 2020

Researchers publish review on HIV-1 Rev Regulatory complex in “Current HIV Research” journal

A team of researchers led by Patrick E. H. Jackson at the Myles H. Thaler Center for HIV and Human Retrovirus Research, University of Virginia, Charlottesville, Virginia, USA, has published a review on the subject of the HIV-1 Rev Regulatory complex (dubbed the HIV-1 Rev Regulatory Axis) in the journal, Current HIV Research.

1 Apr 2020