Statin News and Research

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Statins are drugs used to lower cholesterol. Your body needs some cholesterol to work properly. But if you have too much in your blood, it can stick to the walls of your arteries, narrowing or even blocking them.

Statins not associated with reduced colorectal cancer risk

Use of cholesterol reducing drugs is not associated with a reduced risk of colorectal cancer, according to a study in the Journal of the National Cancer Institute.

8 Jan 2006

Statins do not appear to reduce the incidence of cancer

The cholesterol-lowering medications called statins do not appear to reduce the incidence of cancer or cancer deaths, according to a meta-analysis of previous studies in the January 4 issue of JAMA: The Journal of the American Medical Association.

6 Jan 2006

Implantable defibrillators benefit women as much as men after heart attack

Women who have had a heart attack get as much survival benefit as men from implanted cardioverter defibrillators (ICDs), devices designed to monitor the heart's pumping rhythm and shock it back to normal when needed, according to a study published in the December edition of the Journal of Cardiovascular Electrophysiology.

22 Dec 2005

Physicians slow to prescribe newer heart drugs

An analysis of the treatment received by more than 100,000 heart patients has shown that physicians' prescription practices for drugs proven effective for treating heart disease has shown steady improvement over the past three years, cardiologists at the Duke Clinical Research Institute (DCRI) have concluded.

7 Dec 2005

Lowering of LDL level shows limited benefit for patients with previous heart attack

Patients who have had a heart attack and are treated with a high dose of a statin drug did not have significant reduction in the primary outcome of major cardiac events (coronary death, nonfatal acute heart attack, or cardiac arrest with resuscitation), but did appear to have reduced risk when certain secondary outcomes (composite end points of any coronary heart disease event) were examined, according to a study in the November 16 issue of JAMA.

26 Nov 2005

Why some people do not respond as well as others to statin therapy

A newly discovered genetic variation, in combination with a second variation, reduces the ability of statin drugs to lower "bad" LDL cholesterol, researchers report at the American Heart Association's Scientific Sessions 2005.

20 Nov 2005

Drug pravastatin may provide a previously unknown cardiovascular benefit

The drug pravastatin, which is used widely to decrease high cholesterol, may provide a previously unknown cardiovascular benefit in addition to lowering lipids.

20 Nov 2005

Cholesterol lowering drugs, including statins, may slow the progression of Alzheimer's disease

Cholesterol lowering drugs, including statins, may slow the progression of Alzheimer's disease, concludes a study in the Journal of Neurology Neurosurgery and Psychiatry.

20 Nov 2005

Aspirin advice ignored by those who need it

A daily dose of aspirin is an inexpensive, proven strategy for reducing the likelihood of heart disease among those most at risk for such disorders, yet a new study from the Stanford University School of Medicine shows that aspirin therapy is being used by fewer than one-third of the U.S. outpatients who would benefit from it.

20 Nov 2005

Lack of aggressive treatment for clogged leg blood vessels means missed heart attack prevention opportunity

Despite the fact that clogged arteries in the legs usually mean clogged arteries near the heart, doctors often fail to give heart-protecting drugs to people with severe leg blood vessel blockages, a new University of Michigan-led study finds.

15 Nov 2005

Tricor disappoints in diabetes trial

Researchers say the results of a large trial of a drug to lower triglycerides failed in its primary goal of significantly reducing heart attacks and coronary deaths among patients with type II diabetes.

15 Nov 2005

Role of statin therapy in patients with heart failure

An advanced study launched at Yale School of Medicine is evaluating the role of statin therapy in patients with heart failure, one of the leading causes of hospitalization in people over age 65.

14 Nov 2005

Statins reduce the risk of stroke after carotid artery endarterectomy

Carotid artery endarterectomy (CEA) is the most commonly performed operation to prevent stroke in the United States. However, the operation itself carries a small risk of stroke.

13 Nov 2005

Scientists identify molecular link between body fat and blood lipids

Scientists from Wageningen University in the Netherlands have discovered that a factor released from body fat, which they call Fasting-Induced Adipose Factor or FIAF, has a major impact on blood levels of HDL and triglycerides in mice.

10 Nov 2005

Statin drug reverses learning and attention deficits in a mouse model of the genetic disorder Neurofibromatosis type I

This week, researchers report evidence that a statin drug already shown to be safe for use in humans has proven effective at correcting cell-cell communication and curing learning disfunction in a mouse model of Neurofibromatosis type I, a human genetic disorder that causes learning disabilities in millions of people worldwide.

7 Nov 2005

Cholesterol lowering drugs do not appear to decrease the risk of melanoma

No clear evidence exists that some widely-prescribed cholesterol-lowering drugs can decrease the risk of melanoma, a deadly and malignant skin cancer, according to a new review of recent studies.

7 Nov 2005

Pravastatin is highly effective in lowering the risk of heart attack

The cholesterol-lowering drug pravastatin is highly effective in lowering the risk of heart attack and other cardiovascular events in patients with diabetes and chronic kidney disease (CKD), reports a study in the December Journal of the American Society of Nephrology.

27 Oct 2005

Cholesterol levels and use of statins are not associated with breast cancer risk

Although some evidence suggests that statins (the most commonly used type of lipid-lowering drugs) may inhibit tumor development and may work in combination with chemotherapy drugs against cancer, studies on the association between the use of statins and breast cancer have had conflicting results

25 Oct 2005

New glaucoma risk calculator

High eye pressure is the leading risk factor for glaucoma, and is the only modifiable one. If glaucoma is untreated, vision loss may continue, leading to blindness in some individuals.

17 Oct 2005

Very low LDL cholesterol levels appear to be safe for heart patients on statin therapies

"There was no apparent safety concern for patients whose resultant LDL on intensive therapy was lower than current guidelines. There was a trend toward improved clinical outcomes in the lowest LDL groups," said Stephen D. Wiviott, M.D., from Brigham and Women's Hospital in Boston, Massachusetts.

11 Oct 2005