Stem Cells News and Research

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Stem cells have the remarkable potential to develop into many different cell types in the body during early life and growth. In addition, in many tissues they serve as a sort of internal repair system, dividing essentially without limit to replenish other cells as long as the person or animal is still alive. When a stem cell divides, each new cell has the potential either to remain a stem cell or become another type of cell with a more specialized function, such as a muscle cell, a red blood cell, or a brain cell.

SOX2 neural stem cell gene important in eye development

Scientists at the University of North Carolina at Chapel Hill have demonstrated that normal development of the eye requires the right amount of a neural stem cell gene be expressed at the right time and place.

16 May 2006

Study sheds light on cancer susceptibility and disease involving bone-marrow failure

Defective protein production can occur in cells even when the genes controlling those proteins are normal, according to a new study to be published May 12 in Science.

12 May 2006

Gene amplification could guide treatment for high-risk breast cancer

A new study shows that breast cancer patients with an "amplification," or greater number of copies, of the TOP2A gene are 45% more likely than women who do not have this amplification to benefit from a longer course of anthracycline-based adjuvant chemotherapy.

11 May 2006

Interferon-gamma plays a critical role in damaging the cells that produce myelin

A new way to preserve the cells that surround and protect nerves could lead to new treatments for demyelinating diseases such a multiple sclerosis, a research team reports in the May 10, 2006, issue of the Journal of Neuroscience.

10 May 2006

Promising chemo, therapeutic viruses, cutting-edge surgery debut at M. D. Anderson Cancer Center

Brain tumor specialists at The University of Texas M. D. Anderson Cancer Center are poised on the brink of a new era.

10 May 2006

Stem cell 'fusion' occurs in tumors

An Oregon Health & Science University study is adding credence to an increasingly popular theory that fusion is what bonds stem cells with bone marrow cells to regenerate organ tissue.

10 May 2006

New discovery about role of sugar in cell communication

A research team from Uppsala University has uncovered an entirely new mechanism for how communication between cells is regulated.

9 May 2006

New insight into the way an embryonic retina cell develops

The discovery provides a new vantage point for understanding how a healthy visual system develops. It also raises the possibility of re-directing the production of cell types as needed to stave off eye disease.

9 May 2006

Discovery of new type of cell that generates crucial immune system cells

A new type of cell that generates crucial cells of the immune system has been discovered at The Walter and Eliza Hall Institute.

8 May 2006

DARPA grant supports research toward realizing tissue regeneration

While U.S. soldiers fighting in Iraq and Afghanistan are surviving injuries that in previous conflicts likely would have been fatal, the number of wounded with major tissue loss has never before been so high.

3 May 2006

Differential effects of HOXB4 on nonhuman primate short and long-term repopulating cells

Transplantation of hematopoietic stem cells (HSCs, the cells that can give rise to all blood and most immune cell types) can save patients whose own hematopoietic system is defective or has been destroyed (often through radiation or chemotherapy of cancer).

3 May 2006

Three-dimensional breast cell cultures reveal clues to breast cancer hidden inside stem cells

Stem cells and how to boost them is hot on the research agenda. But stopping them could be critical too, as evidence implicating stem cells in cancer is mounting.

3 May 2006

Sperm-producing stem cells found in testicles could be extracted, grown in the lab, and frozen for future use

Men may cringe at the idea, but sperm-producing stem cells found in testicles could be extracted, grown in the lab, and frozen for future use.

2 May 2006

Transplanted stem cells hoped to be able to regenerate damaged heart muscle in first heart attack victims

Rush cardiologists are hoping that transplanted stem cells can regenerate damaged heart muscle in those who experience a first heart attack. The study involves an intravenous infusion of adult mesenchymal stem cells from healthy donor bone marrow that might possibly reverse damage to heart tissue.

28 Apr 2006

Polycomb proteins key factors in influencing the direction of embryonic stem cell development

Embryonic stem cells may one day provide a means to treat disease, but according to two new reports, they are already revealing remarkable insights into the mysteries of human biology. How humans manage to develop from a single fertilized egg into the trillions of cells that make up a mature adult remains a poorly understood process. Now, using both human and mouse embryonic stem cells, researchers have mapped how a key developmental ingredient controls the genome.

28 Apr 2006

Discovery brings embryonic stem cell medicine a step closer

A team of scientists announced a critical step on the path of realizing the promise of embryonic stem (ES) cells for medicine. The researchers have discovered unique molecular imprints coupled to DNA in mouse ES cells that help explain the cells' rare ability to form almost any body cell type. These imprints, or "signatures," appear near the master genes that control embryonic development and probably coordinate their activity in the early stages of cell differentiation. Not only do these findings help to unlock the basis for ES cells' seemingly unlimited potential, they also suggest ways to understand why ordinary cells are so limited in their abilities to repair or replace damaged cells.

26 Apr 2006

Studies indicate stem cells are flexible enough to become any cell in the body

Two studies in the April 21, 2006 Cell report new details of the "genetic program" that affords embryonic stem cells the flexibility to give rise to any cell type in the body. Both groups identified mechanisms by which the embryonic stem cells of mice or humans keep from going down any one particular developmental path--that of muscle or nervous tissue, for example--while remaining "poised for activation."

26 Apr 2006

Studies indicate stem cells are flexible enough to become any cell in the body

26 Apr 2006

Scientists clarify role of phosphatase and tensin homolog tumor suppressor gene

Jiwang Zhang, Ph.D., formerly a Senior Research Associate at the Stowers Institute for Medical Research, and Linheng Li, Ph.D., Associate Investigator, are credited as the first and last authors, respectively, on a paper highlighting several previously unknown functions of phosphatase and tensin homolog (PTEN), an important tumor suppressor gene.

23 Apr 2006

Adult stem cell implant first in orthopaedic patient

The Royal Melbourne Hospital has performed the world's first implant of cultured specialist stem cells into an orthopaedic patient who suffered a broken femur nine months ago which failed to heal.

19 Apr 2006

Stem Cells News and Research

Further Reading

SOX2 neural stem cell gene important in eye development

Study sheds light on cancer susceptibility and disease involving bone-marrow failure

Gene amplification could guide treatment for high-risk breast cancer

Interferon-gamma plays a critical role in damaging the cells that produce myelin

Promising chemo, therapeutic viruses, cutting-edge surgery debut at M. D. Anderson Cancer Center

Stem cell 'fusion' occurs in tumors

New discovery about role of sugar in cell communication

New insight into the way an embryonic retina cell develops

Discovery of new type of cell that generates crucial immune system cells

DARPA grant supports research toward realizing tissue regeneration

Differential effects of HOXB4 on nonhuman primate short and long-term repopulating cells

Three-dimensional breast cell cultures reveal clues to breast cancer hidden inside stem cells

Sperm-producing stem cells found in testicles could be extracted, grown in the lab, and frozen for future use

Transplanted stem cells hoped to be able to regenerate damaged heart muscle in first heart attack victims

Polycomb proteins key factors in influencing the direction of embryonic stem cell development

Discovery brings embryonic stem cell medicine a step closer

Studies indicate stem cells are flexible enough to become any cell in the body

Studies indicate stem cells are flexible enough to become any cell in the body

Scientists clarify role of phosphatase and tensin homolog tumor suppressor gene

Adult stem cell implant first in orthopaedic patient

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