Structural Protein News and Research

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The universal role of Nsp1: Common mechanisms of translational shutdown by coronaviruses

Researchers investigate Nsp1 from SARS-CoV-2, MERS-CoV, and Bat-Hp-CoV using biophysical, structural, and biochemical assays.

5 Jun 2023

Ecology, transmission, and diagnosis of mosquito-borne Tahyna virus

Researchers summarized the current knowledge on the Tahyna virus (TAHV).

4 May 2023

Study uncovers a novel fold within the SARS-CoV-2 replication co-factor non-structural protein 9

Researchers present the crystal structure of an anti-non-structural protein 9 specific nanobody in complex with the SARS-CoV-2 nsp9.

15 Apr 2023

Study develops a novel intranasal influenza virus-vectored vaccine for SARS-CoV-2

Researchers developed a novel intranasal vaccine candidate for coronavirus disease 2019 (COVID-19).

14 Apr 2023

Low-cost, universal oral COVID-19 vaccine prevents severe respiratory illness in hamsters

A UCLA-led team has developed an inexpensive, universal oral COVID-19 vaccine that prevented severe respiratory illness and weight loss when tested in hamsters, which are naturally susceptible to SARS-CoV-2.

22 Mar 2023

Research highlights the potential risk of secondary SARS-CoV-2 transmission from wild rats

In a recent study published in the journal mBio, researchers in the United States evaluated rat exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in New York City (NYC).

16 Mar 2023

Pathogenicity of SARS-CoV-2 viral components on human periodontal tissues and cells

Researchers assessed the impact of COVID-19 on fibrotic pathogenesis via the deregulation of mitochondrial beta-oxidation.

23 Feb 2023

Repurposing or improving drugs for spinocerebellar ataxia type 5

A team of researchers has developed a new method to screen FDA-approved drugs to determine if they could be repurposed or improved to help patients with a rare, debilitating disease of the nervous system.

16 Feb 2023

Researchers identify inhibitors of the SARS-CoV-2 Nsp14 N7-methyltransferase

A recent study identified inhibitors for SARS-CoV-2 non-structural protein 14 (Nsp14).

17 Jan 2023

Preclinical study shows the therapeutic value of kinetin against SARS-CoV-2

Researchers investigated the ability of kinetin (N6-furfurylaminopurine, MB-905) to inhibit severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) proliferation in vitro.

17 Jan 2023

Researchers analyze targets of human T cell recognition against all coronaviruses

Researchers analyzed T cell reactivity against alpha and beta common cold coronaviruses (CoVs) [(CCC)] to inform the development of pan-CoV vaccine concepts.

9 Jan 2023

New research on nirmatrelvir resistance in SARS-CoV-2 using powerful replicon cell culture systems

In a recent study posted to the bioRxiv* preprint server, researchers at Emory University used severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Washington (WA.1) and Omicron (BA.1) strains to test for mutations that could result in resistance to the antiviral drug nirmatrelvir.

8 Jan 2023

Hair follicle transplants can rejuvenate scars, study finds

In a new study involving three volunteers, skin scars began to behave more like uninjured skin after they were treated with hair follicle transplants.

6 Jan 2023

Vitamin D can help the immune system fight tuberculosis, study says

Most people probably associate tuberculosis with a leaky loft in 20th-century Paris. But as a matter of fact, tuberculosis is not ancient history.

6 Jan 2023

What is the role of SARS-CoV-2 non-structural protein 2 in repressing host antiviral immunity?

Researchers uncovered a novel mechanism that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and other coronaviruses (CoVs) use to exploit host antiviral immune system to facilitate their replication.

5 Jan 2023

mRNA-FISH for the detection of viral RNA in SARS-CoV-2 infected cells and the determination of the kinetics of early RNA replication

Researchers evaluated the early replication kinetics of SARS-CoV-2.

15 Dec 2022

Structural Protein News and Research

The universal role of Nsp1: Common mechanisms of translational shutdown by coronaviruses

Ecology, transmission, and diagnosis of mosquito-borne Tahyna virus

Study uncovers a novel fold within the SARS-CoV-2 replication co-factor non-structural protein 9

Study develops a novel intranasal influenza virus-vectored vaccine for SARS-CoV-2

Low-cost, universal oral COVID-19 vaccine prevents severe respiratory illness in hamsters

Research highlights the potential risk of secondary SARS-CoV-2 transmission from wild rats

Pathogenicity of SARS-CoV-2 viral components on human periodontal tissues and cells

Repurposing or improving drugs for spinocerebellar ataxia type 5

Researchers identify inhibitors of the SARS-CoV-2 Nsp14 N7-methyltransferase

Preclinical study shows the therapeutic value of kinetin against SARS-CoV-2

Researchers analyze targets of human T cell recognition against all coronaviruses

New research on nirmatrelvir resistance in SARS-CoV-2 using powerful replicon cell culture systems

Hair follicle transplants can rejuvenate scars, study finds

Vitamin D can help the immune system fight tuberculosis, study says

What is the role of SARS-CoV-2 non-structural protein 2 in repressing host antiviral immunity?

mRNA-FISH for the detection of viral RNA in SARS-CoV-2 infected cells and the determination of the kinetics of early RNA replication

Research reveals that a viral toxin may contribute to the severity of COVID-19

New study describes two major possible onsets of the COVID-19 pandemic

Moderate alcohol intake may affect lipoprotein metabolism

Research reveals existence of a hidden ''pocket’ on the surface of key SARS-CoV-2 protein

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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