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Scientists explore mutations in the SARS-CoV-2 receptor-binding domain

Researchers assessed the different mutations of concern in the SARS-CoV-2 receptor-binding domain.

6 Jul 2022

Omicron infections have similar incubation periods but shorter generation intervals than Delta infections

Researchers assessed the differences between the generation-interval distributions and incubation periods of the SARS-CoV-2 Delta and Omicron variants.

6 Jul 2022

Targeting C5a/C5aR1 signaling ameliorates COVID-19 immunopathology

A new study investigated the role of complement component 5a (C5a) and its receptor (C5a receptor type 1, C5aR1) in the pathophysiology of COVID-19.

6 Jul 2022

Damon Runyon Cancer Research Foundation names five new Damon Runyon Clinical Investigators

The Damon Runyon Cancer Research Foundation has named five new Damon Runyon Clinical Investigators.

6 Jul 2022

Bereavement linked to increased risk of death in heart failure patients

Heart failure patients experiencing grief or in mourning following the loss of a close family member are at an increased risk of death, particularly during the first week following the family member's death, according to a study published today in JACC: Heart Failure.

6 Jul 2022

Study yields molecular clues that could lead to new treatments for rare genetic disease

A new stem cell study by KAUST researchers helps to explain a rare genetic disease called Wiskott-Aldrich syndrome (WAS), yielding molecular clues that could lead to new treatments for a devastating immune deficiency disorder.

6 Jul 2022

Pregnancies following frozen embryo transfer have higher risk of hypertensive disorders

Concerns have been raised over the past few years that pregnancies derived from frozen embryo transfers in IVF might increase the maternal risk of hypertensive disorders, particularly pre-eclampsia, complications which may have severe consequences for the mother and fetus.

6 Jul 2022

The host cell membrane binding surfaces of SARS-CoV-2 spike variants

Researchers identified SARS-CoV-2 spike surfaces involved in binding to host cell membranes.

6 Jul 2022

Beyond COVID-19: the potential future applications of mRNA vaccines

Researchers described the production, mechanisms, and potential applications of mRNA vaccines.

6 Jul 2022

Intrahost genetic diversity and evolution of the SARS-CoV-2 B.1.517 lineage during chronic infection of an immunocompromised individual

Researchers investigated the intrahost evolution and genetic diversity of the SARS-CoV-2 B.1.517 variant in an immunosuppressed person with chronic COVID-19.

6 Jul 2022

The global biogeography of bat-origin betacoronaviruses

Researchers developed a spatial and quantitative framework to explore the biogeography of and map the evolutionary risk of bat-origin βCoVs such as SARS-CoV, SARS-CoV-2 and MERS-CoV based on the geographic mosaic theory of coevolution.

6 Jul 2022

How does hybrid immunity shape humoral immune response to SARS-CoV-2?

In a recent study posted to the medRxiv* preprint server, researchers illustrated that hybrid severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immunity widens effective humoral signatures of SARS-CoV-2 vaccinations.

6 Jul 2022

"Selfish chromosomes" explain why most human embryos die very early on, study suggests

New research by a scientist at the Milner Center for Evolution at the University of Bath suggests that "selfish chromosomes" explain why most human embryos die very early on. The study, published in PLoS, Biology, explaining why fish embryos are fine but sadly humans' embryos often don't survive, has implications for the treatment of infertility.

6 Jul 2022

Research highlights importance of designing effective COVID vaccine allocation strategies

In a recent study posted to the medRxiv* pre-print server, researchers at the University of Melbourne used a modified Susceptible, Exposed, Infectious, and Recovered (SEIR) mathematical model to examine the impact of different vaccine mechanisms and disease characteristics on a population comprised of individuals at high and low risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.

6 Jul 2022

Paxlovid resistance associated with SARS-CoV-2 3CLpro mutations

In a recent study published in the bioRxiv* preprint server, researchers at the Medical University of Innsbruck assessed the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) 3CLpro mutations responsible for Paxlovid resistance. The 3-chymotrypsin-like protease (3CLPro), or main protease (Mpro), is the main protease found in coronaviruses.

6 Jul 2022

Healthy, cancer, and immunosuppressed patients all benefit from COVID boosters

In a recent study posted to the medRxiv* pre-print server, researchers developed a mechanistic mathematical model to predict the course of vaccine-induced immunity in healthy and immunosuppressed patients for the long term, exceeding the time frames for which clinical data is currently available.

5 Jul 2022

Novel inhalable COVID-19 vaccine

A recent study published in the Nature Biomedical Engineering journal illustrated a novel inhalable SARS-CoV-2 vaccine candidate centered on exosomes (Exos) coupled with recombinant severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) receptor-binding domain (RBD).

5 Jul 2022

What causes insomnia and how to treat it?

A new study evaluates the symptoms of insomnia and its treatment as reported by patients in primary care settings.

5 Jul 2022

Has the COVID pandemic affected breastfeeding intention?

A new study discusses the impact of the pandemic on breastfeeding practices.

5 Jul 2022

SARS-Cov-2 Omicron variant raises significant concerns about high transmissibility in China

Omicron (B.1.1.529), the fifth variant of concern (VOC) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was firstly identified in November 2021 in South Africa. Omicron contains far more genome mutations than any other VOCs ever found, raising significant concerns about its increased transmissibility and immune evasion.

5 Jul 2022

Syndrome News and Research

Scientists explore mutations in the SARS-CoV-2 receptor-binding domain

Omicron infections have similar incubation periods but shorter generation intervals than Delta infections

Targeting C5a/C5aR1 signaling ameliorates COVID-19 immunopathology

Damon Runyon Cancer Research Foundation names five new Damon Runyon Clinical Investigators

Bereavement linked to increased risk of death in heart failure patients

Study yields molecular clues that could lead to new treatments for rare genetic disease

Pregnancies following frozen embryo transfer have higher risk of hypertensive disorders

The host cell membrane binding surfaces of SARS-CoV-2 spike variants

Beyond COVID-19: the potential future applications of mRNA vaccines

Intrahost genetic diversity and evolution of the SARS-CoV-2 B.1.517 lineage during chronic infection of an immunocompromised individual

The global biogeography of bat-origin betacoronaviruses

How does hybrid immunity shape humoral immune response to SARS-CoV-2?

"Selfish chromosomes" explain why most human embryos die very early on, study suggests

Research highlights importance of designing effective COVID vaccine allocation strategies

Paxlovid resistance associated with SARS-CoV-2 3CLpro mutations

Healthy, cancer, and immunosuppressed patients all benefit from COVID boosters

Novel inhalable COVID-19 vaccine

What causes insomnia and how to treat it?

Has the COVID pandemic affected breastfeeding intention?

SARS-Cov-2 Omicron variant raises significant concerns about high transmissibility in China

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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