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WHO's new List of Essential Medicines prioritizes access to diabetes and cancer treatments

WHO today published the new edition of its Model Lists of Essential Medicines and Essential Medicines for Children, which include new treatments for various cancers, insulin analogues and new oral medicines for diabetes, new medicines to assist people who want to stop smoking, and new antimicrobials to treat serious bacterial and fungal infections.

1 Oct 2021

Two-mAb cocktail prevents SARS-CoV-2 infection, study suggests

A promising study shows that a combination of two monoclonal antibodies effectively neutralized SARS-CoV-2 in monkeys and proved efficacious against newer variants of concern in vitro.

1 Oct 2021

Enveloped virus-like particle based vaccines potentially broaden immunity against SARS-CoV-2 variants

A new preprint describes promising results with a novel vaccine candidate designed to improve the breadth of neutralization.

1 Oct 2021

Structure of monoclonal antibody that can potently neutralize SARS-CoV-2 and variants of concern

A new preprint deals with the analysis of the monoclonal antibody J08, which was capable of powerful neutralization of the wildtype SARS-CoV-2, and its VOCs.

1 Oct 2021

Persistence of humoral immune response in SARS-CoV-2 convalescent individuals a year after infection

A new study reported the persistence of immune responses over twelve months after natural infection.

1 Oct 2021

Similar viral load in vaccinated and unvaccinated individuals infected with SARS-CoV-2 Delta variant

Researchers evaluated Ct-values among distinct groups, namely, a) completely vaccinated and unvaccinated individuals and b) asymptomatic and symptomatic individuals at the time of testing.

1 Oct 2021

The extent to which COVID-19 vaccination reduces transmission varies with vaccine type and SARS-CoV-2 strain

Researchers from the University of Oxford have been examining the impact of vaccination on the spread of the Alpha and Delta variants through the population.

1 Oct 2021

Study finds US pediatric COVID-19 cases are higher than expected

Researchers from the CDC have investigated differences in seroprevalence across pediatric age groups to estimate an infection to case ratio.

1 Oct 2021

Study reveals how the blood and immune systems develop in prenatal bone marrow

The first comprehensive analysis of how the blood and immune systems develop in prenatal bone marrow has been conducted by scientists at the Wellcome Sanger Institute, Newcastle University and their collaborators.

1 Oct 2021

Comparison of Pfizer, Moderna, J&J, AZ vaccines for neutralization titer, against Delta and other variants

Is one COVID vaccine better than the other? Four current vaccines — Moderna, Pfizer-BioNTech, Johnson & Johnson, and AstraZeneca — are highly effective against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), but a new medRxiv* study suggests the level of protection varies.

30 Sep 2021

Non-severe COVID-19 may elicit more durable memory B cell response than severe COVID-19

A recent study conducted by researchers from the US aimed to measure the impact of severity of COVID-19 on memory B cell response and characterize changes in the memory B cell compartment during the period between recovery and five months after symptom onset. This study is available on the bioRxiv* preprint server.

30 Sep 2021

Dual therapy improves cardiac outcomes in pediatric patients suffering from MIS-C

A recent study by a multidisciplinary team of cardiologists and infectious disease specialists at Children's Hospital Colorado (Children's Colorado) found that pediatric patients suffering from Multisystem Inflammatory Syndrome (MIS-C) who received initial, intensified therapy consisting of intravenous immunoglobulin (IVIG) plus Infliximab had improved cardiac outcomes versus those who received IVIG alone.

30 Sep 2021

Early-stage interaction of monocytes with SARS-CoV-2-infected epithelial cell decides COVID-19 severity

A team of scientists from the USA and France has recently unveiled the mechanism of immune dysregulation in coronavirus disease 2019 (COVID-19) patients by analyzing the early-stage interaction between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected epithelial cells and immune cells. The study is currently available on the bioRxiv* preprint server.

30 Sep 2021

The connection between age and virulence of SARS-CoV-2 variants of concern

A new study focuses on determining the existence of an age-related heterogeneity in the severity of COVID-19.

30 Sep 2021

SARS-CoV-2 nucleocapsid antigen as a possible COVID-19 severity marker

French researchers used a highly sensitive and specific nucleocapsid-Ag assay to explore the relationship between N-Ag in urine during COVID-19 and the severity of the disease in hospitalized patients.

30 Sep 2021

The applications of nanomaterials against viral disease

The application of nanomaterials in the diagnosis, prevention, and treatment of viral diseases is reviewed in detail, highlighting areas of significant progress or stagnation from the past few decades.

30 Sep 2021

Diverse vaccine attitudes amongst UK healthcare workers suggest hesitancy may remain after vaccine acceptance

In a recent paper, the phenomenon of vaccine hesitancy is further explored amongst UK healthcare workers.

30 Sep 2021

SARS-CoV-2 infection aided by antibody-dependent enhancement

The coronavirus disease 2019 (COVID-19) pandemic has raised concerns about the detrimental effects of antibodies. Antibody-dependent enhancement (ADE) of infection is one of the biggest concerns in terms of not only the antibody reaction to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) upon reinfection with the virus but also the reaction to COVID-19 vaccines.

30 Sep 2021

Instrument to measure risk of reverse zoonotic SARS-CoV-2 transmission events from humans to animals

A new study published on the medRxiv* preprint server presents a standardized survey instrument for evaluating risk factors associated with bidirectional zoonotic transmission of SARS-CoV-2 and pathogens. The instrument is particularly focused on settings where humans and animals share close contact.

30 Sep 2021

Scientists describe SARS-CoV-2 uptake in tissue-resident human macrophages enhanced by virus-specific antibodies

Now, in a new news study posted to the bioRxiv* preprint server, researchers have successfully induced similar chronicity associated with SARS-CoV-2 infection in MISTRG6-hACE2 humanized mice.

29 Sep 2021

Syndrome News and Research

WHO's new List of Essential Medicines prioritizes access to diabetes and cancer treatments

Two-mAb cocktail prevents SARS-CoV-2 infection, study suggests

Enveloped virus-like particle based vaccines potentially broaden immunity against SARS-CoV-2 variants

Structure of monoclonal antibody that can potently neutralize SARS-CoV-2 and variants of concern

Persistence of humoral immune response in SARS-CoV-2 convalescent individuals a year after infection

Similar viral load in vaccinated and unvaccinated individuals infected with SARS-CoV-2 Delta variant

The extent to which COVID-19 vaccination reduces transmission varies with vaccine type and SARS-CoV-2 strain

Study finds US pediatric COVID-19 cases are higher than expected

Study reveals how the blood and immune systems develop in prenatal bone marrow

Comparison of Pfizer, Moderna, J&J, AZ vaccines for neutralization titer, against Delta and other variants

Non-severe COVID-19 may elicit more durable memory B cell response than severe COVID-19

Dual therapy improves cardiac outcomes in pediatric patients suffering from MIS-C

Early-stage interaction of monocytes with SARS-CoV-2-infected epithelial cell decides COVID-19 severity

The connection between age and virulence of SARS-CoV-2 variants of concern

SARS-CoV-2 nucleocapsid antigen as a possible COVID-19 severity marker

The applications of nanomaterials against viral disease

Diverse vaccine attitudes amongst UK healthcare workers suggest hesitancy may remain after vaccine acceptance

SARS-CoV-2 infection aided by antibody-dependent enhancement

Instrument to measure risk of reverse zoonotic SARS-CoV-2 transmission events from humans to animals

Scientists describe SARS-CoV-2 uptake in tissue-resident human macrophages enhanced by virus-specific antibodies

Achieving and maintaining ISO 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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