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Water-soluble vitamin E compounds directly inhibit SARS-CoV-2 replication and synergize with remdesivir

Researchers in the United States have shown that water-soluble derivatives of vitamin E (α-tocopherol) exhibit potent antiviral activity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19).

15 Jul 2021

COVID-19 vaccine candidate that can be produced in yeast proves effective in macaques

Researchers in the United States have designed a modular protein subunit vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that elicited a strong immune response in macaques and prevented the animals from developing coronavirus disease 2019 (COVID-19).

15 Jul 2021

COVID-19 researchers review 184 drug repurposing candidates

New research describes the use of integrative bioinformatics analyses of transcriptomic profiles for COVID-19 therapeutics.

15 Jul 2021

About 4 in 100 COVID-19 hospitalized children may develop neurological complications, a study finds

In a recently published article in The Lancet’s Child & Adolescent Health, scientists have described in detail neurological and psychiatric manifestations of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in children. As mentioned in the study, an estimated prevalence of infection-related neurological complications and pediatric inflammatory multisystem syndrome in hospitalized children and adolescents is about 3.8 cases per 100 patients.

15 Jul 2021

Heart problems in kids with MIS-C resolve rapidly, study shows

Heart problems in children hospitalized with multisystem inflammatory syndrome (MIS-C)--an inflammatory condition triggered by COVID--were mostly gone within a few months, a new study by researchers at Columbia University Vagelos College of Physicians and Surgeons and NewYork-Presbyterian has found.

15 Jul 2021

Potential compounds targeting SARS-COV-2 main protease (in vivo)

Now, new research published in the journal Hippokratia focuses on assisting the ongoing COVID-19 therapeutic research by developing a new method to identify active compounds that have the potential to fight against COVID-19 infection.

15 Jul 2021

Study reveals key mechanisms of how physical load stimulates bone growth

When things get too much, we're often advised to "take a load off," but when it comes to bone maintenance, doing the opposite can be a good thing. Researchers from Japan have discovered some key mechanisms of how physical load stimulates bone growth.

15 Jul 2021

Short chain fatty acids have potential therapeutic applications against COVID-19, study suggests

SARS-CoV-2, the virus responsible for the COVID-19 pandemic, is highly transmissible, with nasal passages being the target of original infection.

15 Jul 2021

Rapid COVID-19 antibody detection with time‐resolved fluorescence immunoassay

A new study published in the journal Biotechnology and Applied Biochemistry deals with the development of a time-resolved fluorescence immunoassay (TRFIA) for the detection of total COVID-19 antibodies in humans.

15 Jul 2021

Study finds clear association between hemoglobin levels and key cardiovascular traits

A new study led by the University of Oulu in Finland refutes the belief that high hemoglobin levels are always desirable for health.

15 Jul 2021

Should we be concerned about the SARS-CoV-2 Lambda variant?

As the coronavirus disease (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), wreaks havoc across the globe, the efficacy of available vaccines is being threatened by emerging variants.

15 Jul 2021

A pencil graphite biosensor that detects SARS-CoV-2

In a new study, scientists discuss the development of a rapid COVID-19 diagnostic tool known as the Low-cost Electrochemical Advanced Diagnostic (LEAD).

14 Jul 2021

“Herd immunity” not responsible for Sweden’s control of COVID-19, say researchers

Researchers in Sweden have challenged the interpretation that variable non-pharmaceutical interventions (NPIs) and “herd immunity” protection are responsible for the rise and fall of coronavirus disease 2019 (COVID-19) epidemic waves in hard-hit locations where authorities have not enforced strict NPIs.

14 Jul 2021

New OMV-based COVID-19 vaccine candidate proves effective in mice

Researchers in Italy have demonstrated the efficacy of using modified outer membrane vesicles (OMVs) as a vaccine to protect against coronavirus disease 2019 (COVID-19) in an animal model.

14 Jul 2021

Could corticosteroids increase mortality in COVID-19 patients without high oxygen supplementation?

A new paper focuses on the role of corticosteroids, in particular, as these were widely used among patients on intensive respiratory support (IRS).

14 Jul 2021

Nanopore technology allows point-of-care SARS-CoV-2 genomic sequencing

As the SARS-CoV-2 continues to spread worldwide and cause disease and death on a devastating scale, genomic sequencing has become a primary method of keeping track of emerging variants and new outbreaks. A new medRxiv* preprint explores the role of nanopore sequencing in this effort.

14 Jul 2021

COVID-19 vaccine booster strategy against Delta variant evidence of growing inequity, says WHO

Could the COVID-19 vaccine booster dose strategy being planned in wealthyy nations underscore issues of health inequality?

14 Jul 2021

Is niclosamide a potential SARS-CoV-2 antiviral inhibitor?

Niclosamide is an antihelminthic drug, historically used to treat tapeworm infestations, though has been investigated and repurposed for use against SARS-CoV-2. In a new study recently uploaded to the preprint server bioRxiv* by Garrett et al. (July 12, 2021), the drug demonstrates the ability to reorganize the lipid profile of SARS-CoV-2 infected Vero E6 cells, thereby limiting virus replication.

14 Jul 2021

Researchers examine efficacy of CT-P59 monoclonal antibody against SARS-CoV-2 Brazil variant

The therapeutic monoclonal antibody CT-P59 binds to the RBD of SARS-CoV-2, the site of these three major mutations, which may therefore reduce the potency of this antibody against the P.1 lineage. In a new study, the neutralizing potency of this monoclonal antibody towards both wildtype and P.1 SARS-CoV-2 is investigated. The researchers found that the ability to bind with the virus is impeded by the mutations, resulting in reduced potency in vitro.

14 Jul 2021

People with learning disabilities are at higher risk of covid-19 related hospitalizations, deaths

People with learning disabilities with covid-19 are five times more likely to be admitted to hospital and eight times more likely to die compared with the general population of England, finds a study published by The BMJ today.

14 Jul 2021

Syndrome News and Research

Water-soluble vitamin E compounds directly inhibit SARS-CoV-2 replication and synergize with remdesivir

COVID-19 vaccine candidate that can be produced in yeast proves effective in macaques

COVID-19 researchers review 184 drug repurposing candidates

About 4 in 100 COVID-19 hospitalized children may develop neurological complications, a study finds

Heart problems in kids with MIS-C resolve rapidly, study shows

Potential compounds targeting SARS-COV-2 main protease (in vivo)

Study reveals key mechanisms of how physical load stimulates bone growth

Short chain fatty acids have potential therapeutic applications against COVID-19, study suggests

Rapid COVID-19 antibody detection with time‐resolved fluorescence immunoassay

Study finds clear association between hemoglobin levels and key cardiovascular traits

Should we be concerned about the SARS-CoV-2 Lambda variant?

A pencil graphite biosensor that detects SARS-CoV-2

“Herd immunity” not responsible for Sweden’s control of COVID-19, say researchers

New OMV-based COVID-19 vaccine candidate proves effective in mice

Could corticosteroids increase mortality in COVID-19 patients without high oxygen supplementation?

Nanopore technology allows point-of-care SARS-CoV-2 genomic sequencing

COVID-19 vaccine booster strategy against Delta variant evidence of growing inequity, says WHO

Is niclosamide a potential SARS-CoV-2 antiviral inhibitor?

Researchers examine efficacy of CT-P59 monoclonal antibody against SARS-CoV-2 Brazil variant

People with learning disabilities are at higher risk of covid-19 related hospitalizations, deaths

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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