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Decreasing activity of ZMPSTE24 protease with age and comorbidities may make elderly COVID-19 patients vulnerable

Studies have shown that circulating levels of PAI-1, the coagulation cascade activator, are considerably higher in COVID-19 patients with severe respiratory illness compared to patients with bacterial-sepsis and acute respiratory distress syndrome (ARDS). Hence the increase in PAI-1 levels is recognized as an early marker of endothelial dysfunction in COVID-19 patients.

23 May 2021

SARS-CoV-2 mutations strengthen RBD-ACE2 binding, making the virus more infectious

In January 2020, the first complete severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) genome sequence was deposited to GenBank. Since then, the amount of new genome sequences has increased rapidly at GenBank and GISAID. This has laid the foundations for analyzing the virulence, antigenicity, pathogenicity, and transmissibility of SARS-CoV-2 mutations.

22 May 2021

SARS-CoV-2 B.1.1.7 and B.1.351 variants exhibit enhanced affinity towards the ACE2 receptor

In a short correspondence paper recently uploaded to the Lancet by Ramanathan, Muthukumar et al. (May 19th, 2021) the affinity of labeled SARS-CoV-2 spike receptor-binding domain proteins sourced from each of these two variants of concern towards human angiotensin-converting enzyme 2 (ACE2) recombinant proteins is investigated using microscale thermophoresis, confirming the enhanced affinity towards the receptor observed in other studies.

22 May 2021

SARS-CoV-2 virus persistence in immunocompromised individuals

Positive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) tests are frequently obtained from individuals that have already recovered from the virus in the past. They have therefore undergone seroconversion and bear the expected antibodies.

22 May 2021

High seroprevalence in Peruvian population recovering from SARS-CoV-2 infection

By the middle of 2020, Iquitos, Peru, had the highest number of SARS-CoV-2 antibodies in the world. Despite natural immunity, the city experienced a second coronavirus wave, with reinfections possibly owing to the P.1 variant.

22 May 2021

Landmark study confirms that controlled blood pressure is key to prevent stroke, heart disease

Follow-up data from the landmark SPRINT study of the effect of high blood pressure on cardiovascular disease have confirmed that aggressive blood pressure management -- lowering systolic blood pressure to less than 120 mm Hg -- dramatically reduces the risk of heart disease, stroke, and death from these diseases, as well as death from all causes, compared to lowering systolic blood pressure to less than 140 mm Hg.

22 May 2021

Australian discovery could speed up SARS-CoV-2 vaccine development

To address this gap, researchers from Australia recently examined the relationship between levels of in vitro neutralization and the observed protection obtained from SARS-CoV-2 infection. They used data from 7 currently available vaccines and convalescent cohorts. Their research is published in the journal Nature Medicine.

22 May 2021

When COVID-19 is severe, rogue antibodies attack body tissues and organs

The study, published in the journal Nature, sheds light on the disease mechanism of COVID-19 and how the virus causes a faulty immune system.

21 May 2021

Modeling SARS-CoV-2 spike/human ACE2 complex identifies high-affinity variants that cause greater transmissibility

The study, published in the Journal of Molecular Biology, shows promise in detecting potential new variants that can cause the faster spread of COVID-19. The recent mutations and variants detected have caused the rapid spread of the infection in many countries.

21 May 2021

Plant-based vaccine against SARS-CoV-2 shows promise

Researchers at Canadian biotechnology company Medicago report that Phase 1 trials of a plant-based vaccine for SARS-CoV-2 are underway and showing promise.

21 May 2021

Campylobacter infection can also be spread through sexual contact

Campylobacter infection, one of the most common foodborne illnesses in the Western world, can also be spread through sexual contact, according to a new research discovery by an OU Hudson College of Public Health faculty member, working in conjunction with colleagues in Denmark.

21 May 2021

Novel broad-spectrum antiviral compounds effective against Zika and SARS-CoV-2

A research team at the University of Alberta, Canada, led by Dr. Daniel Limonta, has described two novel molecules with broad antiviral properties that are effective against a range of virus types, including SARS-CoV-2.

21 May 2021

How do common mutations in SARS-CoV-2’s spike affect its binding affinity with host cell receptors?

Antibodies produced during a previous case of COVID-19 or vaccine-induced immunity are targeted towards S protein, where the neutralizing antibodies attach to the Spike RBD domain. Some of the variants have mutations in their RBD domain, causing resistance to the neutralizing antibodies. However, the effect of these mutations on the affinity and kinetics of the binding of Spike RBD to ACE2 is not clear. A new study has been published on the bioRxiv* preprint server, which deals with the study of affinity and kinetic analysis of the interface between Spike RBD and ACE2 at physiological temperatures.

21 May 2021

Pfizer-BioNTech vaccination not associated with platelet activation in new study

Among the devastating complications of severe or critical coronavirus disease 2019 (COVID-19), clot formation ranks high in the adverse impact it creates. An important question is whether SARS-CoV-2-spike-based vaccines also cause such coagulopathies. A new study, released as a preprint on the medRxiv* server, examines this risk for the first time.

21 May 2021

Risk factors for rare COVID-19 complications in children (MIS-C)

While the earlier waves of COVID-19 relatively spared children, some of the affected children have developed a systemic inflammatory condition, with occasionally fatal outcomes. Called multisystem inflammatory syndrome in children (MIS-C), its pathogenesis and risk factors are the subject of a new study on the medRxiv* preprint server.

21 May 2021

Can SARS-CoV-2 trigger amyloidosis?

A new study, released as a preprint on the bioRxiv* server, describes the results of an analysis of the role played by the virus in amyloid formation, with its subsequent effects on the health of various organs and of the whole organism.

21 May 2021

Electrospun nanofibrous filters capture 99.9 percent of coronavirus aerosols, study finds

Researchers at The George Washington University and the University of California in the U.S. compared the efficacy of surgical and cotton masks, a neck gaiter, and electrospun nanofiber membranes to capture coronavirus aerosols and prevent airborne transmission.

21 May 2021

Should colorectal cancer screening start at age 45?

Colorectal cancer rates among young adults are steadily increasing over the years. The United States Task Force has long recommended that people aged 50 to 75 get screened. Now, the U.S. Preventive Services Task Force updated its 2016 recommendation of colorectal screening for people aged 50, down to 45 years old. The five-year earlier screening can save many lives by allowing earlier diagnosis and treatment of the condition.

21 May 2021

Masks and physical distancing could reduce SARS-CoV-2 spread to 1% among essential food plant workers, says study

The food supply is an essential service. Yet, workers in this industry are at high risk of acquiring infection with the novel coronavirus in their workplace unless proper mitigation measures are put in place. A new study, released as a preprint on the medRxiv* server, shows that the risk of infection may be reduced to less than 1% with proper precautions.

21 May 2021

Facets of SARS-CoV-2 infection and animal models

A new study in the journal Frontiers in Cell and Developmental Biology discusses the ribonucleic acid (RNA) genome of the virus, and the mechanisms by which it establishes infection within the host cell. The researchers also summarize the development of animal models of COVID-19, which will both help understand the clinical features of the illness, and indicate new approaches for the treatment of the infection.

21 May 2021

Syndrome News and Research

Decreasing activity of ZMPSTE24 protease with age and comorbidities may make elderly COVID-19 patients vulnerable

SARS-CoV-2 mutations strengthen RBD-ACE2 binding, making the virus more infectious

SARS-CoV-2 B.1.1.7 and B.1.351 variants exhibit enhanced affinity towards the ACE2 receptor

SARS-CoV-2 virus persistence in immunocompromised individuals

High seroprevalence in Peruvian population recovering from SARS-CoV-2 infection

Landmark study confirms that controlled blood pressure is key to prevent stroke, heart disease

Australian discovery could speed up SARS-CoV-2 vaccine development

When COVID-19 is severe, rogue antibodies attack body tissues and organs

Modeling SARS-CoV-2 spike/human ACE2 complex identifies high-affinity variants that cause greater transmissibility

Plant-based vaccine against SARS-CoV-2 shows promise

Campylobacter infection can also be spread through sexual contact

Novel broad-spectrum antiviral compounds effective against Zika and SARS-CoV-2

How do common mutations in SARS-CoV-2’s spike affect its binding affinity with host cell receptors?

Pfizer-BioNTech vaccination not associated with platelet activation in new study

Risk factors for rare COVID-19 complications in children (MIS-C)

Can SARS-CoV-2 trigger amyloidosis?

Electrospun nanofibrous filters capture 99.9 percent of coronavirus aerosols, study finds

Should colorectal cancer screening start at age 45?

Masks and physical distancing could reduce SARS-CoV-2 spread to 1% among essential food plant workers, says study

Facets of SARS-CoV-2 infection and animal models

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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