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Multi-organ scRNA-seq reveals targeting pro- or anti-inflammatory regulators may be exploited for personalized treatment of immune diseases

Researchers performed multi-organ single-cell RNA sequencing of collagen-induced arthritis murine model to evaluate immune-mediated inflammatory disease alterations by characterizing the genome, organizing the organome, and prioritizing pathways in the multi-organ data.

3 Mar 2023

Scientists use systems biology approach to identify molecular players in rheumatoid arthritis

Using a novel systems biology approach, scientists at University of California San Diego School of Medicine have further parsed the cellular players and roles involved in rheumatoid arthritis (RA), a complex disease that affects more than one million Americans in ways that have defied development of uniform treatments.

24 Oct 2022

Study identifies an epigenetic regulator that suppresses pathogenic events in rheumatoid arthritis

Rheumatoid arthritis (RA) is characterized by chronic inflammation of synovium, eventually leading to joint destruction. Epigenetic alteration (the mechanism of gene expression regulation without DNA sequence changes), such as low levels of DNA methylation, is one of the factors which worsens the RA state.

8 Jun 2022

Computer vision tool effectively distinguishes rheumatoid arthritis from osteoarthritis in joint tissue

A new study led by Hospital for Special Surgery investigators in New York City has found that their computer vision tool effectively distinguishes rheumatoid arthritis (RA) from osteoarthritis (OA) in joint tissue taken from patients who underwent total knee replacement (TKR).

3 Jun 2022

NYU Langone joins NIH-sponsored program as leading center to discover new targets for autoimmune, inflammatory diseases

NYU Langone Health is joining a new National Institutes of Health (NIH)-sponsored program called Accelerating Medicines Partnership Autoimmune and Immune-Mediated Diseases (AMP AIM) as a leading center to discover new targets for therapy in these diseases.

30 Mar 2022

Novel type of cellular therapy safe for knee pain caused by osteoarthritis, study confirms

A study released in STEM CELLS Translational Medicine has confirmed the safety of a novel type of cellular therapy for knee pain caused by osteoarthritis.

3 Aug 2021

Corticosteroid injections for knee OA do not speed up the progression of disease

New research shows that corticosteroid injections for knee OA treatment do not hasten a patient's progression to a total knee replacement when compared with hyaluronic acid injections.

6 Nov 2020

High-resolution TB-PET/CT scanner reveals complete picture of systemic inflammatory arthritis

For the first time, physicians can examine the systemic burden of inflammatory arthritis simultaneously across all joints and organ systems, using the high-sensitivity, high-resolution uEXPLORER total-body positron emission tomography/computed tomography (TB-PET/CT) scanner.

13 Jul 2020

Updated guideline for management of osteoarthritis of the hand, hip and knee released

Today, the American College of Rheumatology, in partnership with the Arthritis Foundation, released the 2019 ACR/AF Guideline for the Management of Osteoarthritis of the Hand, Hip and Knee.

7 Jan 2020

Pilot study shows strong results for genicular artery embolization to treat OA-related knee pain

A new study published in Journal of Vascular and Interventional Radiology details the first study of its kind in the U.S. to examine the use of genicular artery embolization (GAE) for extended treatment of knee pain caused by osteoarthritis.

17 Dec 2019

Rheumatoid arthritis linked to other diseases, finds new study

A study found that risk of developing rheumatoid arthritis is higher in people with certain diseases.

21 Nov 2019

Research highlights benefits of oral prednisolone in patients with hand osteoarthritis

Research presented at the 2019 ACR/ARP Annual Meeting found that a six-week treatment with low-dose oral prednisolone substantially improves pain and decreases signs of inflammation in patients with painful hand osteoarthritis.

11 Nov 2019

Opioids do not improve quality of life or depression in OA patients

New research presented at the 2019 ACR/ARP Annual Meeting suggests that opioids contribute no measurable benefit to quality of life or depression for patients with osteoarthritis (OA).

11 Nov 2019

Methotrexate appears to facilitate bone remodeling in patients with osteoarthritis

According to new research findings presented at the 2019 ACR/ARP Annual Meeting, methotrexate did not demonstrate superior efficacy over placebo for pain relief and function evolution at three and 12 months in patients with erosive hand osteoarthritis.

11 Nov 2019

Osteoarthritis has no cure, but symptoms can be managed

Osteoarthritis can't be ignored. On a grand scale, it is the most common form of arthritis (which actually isn't a specific disease but rather a general term for inflammation in a joint), accounting for more cases than all the other forms combined. It affects an estimated 31 million Americans and is a leading cause of disability among adults.

10 Oct 2019

FDA approves first therapy for symptomatic tenosynovial giant cell tumor

Today, the U.S. Food and Drug Administration granted approval to Turalio (pexidartinib) capsules for the treatment of adult patients with symptomatic tenosynovial giant cell tumor (TGCT) associated with severe morbidity or functional limitations and not responsive to improvement with surgery.

3 Aug 2019

Researchers identify new clues on tissue damage in rheumatoid arthritis and lupus

Research supported by the Accelerating Medicines Partnership on Rheumatoid Arthritis and Systemic Lupus Erythematosus provides new insights into tissue damage for these autoimmune conditions.

19 Jun 2019

New TSPO-targeted PET imaging more fully evaluates extent of rheumatoid arthritis

A new positron emission tomography imaging method more fully evaluates the extent of rheumatoid arthritis by targeting translocator protein expression in the synovium (joint lining tissue).

10 Jul 2018

Studies provide insight into molecular changes prior to onset of arthritis

The results of two studies presented today at the Annual European Congress of Rheumatology (EULAR 2018) provide insight into molecular changes prior to the onset of arthritis which could inform future novel diagnostics and early therapeutic interventions.

18 Jun 2018

Researchers uncover the cause of rheumatoid arthritis

A team of researchers have identified the cellular network involved in initiating and maintaining chronic inflammation in rheumatoid arthritis.

30 May 2018

Synovium News and Research

Multi-organ scRNA-seq reveals targeting pro- or anti-inflammatory regulators may be exploited for personalized treatment of immune diseases

Scientists use systems biology approach to identify molecular players in rheumatoid arthritis

Study identifies an epigenetic regulator that suppresses pathogenic events in rheumatoid arthritis

Computer vision tool effectively distinguishes rheumatoid arthritis from osteoarthritis in joint tissue

NYU Langone joins NIH-sponsored program as leading center to discover new targets for autoimmune, inflammatory diseases

Novel type of cellular therapy safe for knee pain caused by osteoarthritis, study confirms

Corticosteroid injections for knee OA do not speed up the progression of disease

High-resolution TB-PET/CT scanner reveals complete picture of systemic inflammatory arthritis

Updated guideline for management of osteoarthritis of the hand, hip and knee released

Pilot study shows strong results for genicular artery embolization to treat OA-related knee pain

Rheumatoid arthritis linked to other diseases, finds new study

Research highlights benefits of oral prednisolone in patients with hand osteoarthritis

Opioids do not improve quality of life or depression in OA patients

Methotrexate appears to facilitate bone remodeling in patients with osteoarthritis

Osteoarthritis has no cure, but symptoms can be managed

FDA approves first therapy for symptomatic tenosynovial giant cell tumor

Researchers identify new clues on tissue damage in rheumatoid arthritis and lupus

New TSPO-targeted PET imaging more fully evaluates extent of rheumatoid arthritis

Studies provide insight into molecular changes prior to onset of arthritis

Researchers uncover the cause of rheumatoid arthritis

Unlocking the Secrets of Multiple Sclerosis Progression: Brain-Immune Cell Communication

Passing on Polycystic Ovary Syndrome: Health risks for male offspring of women with PCOS

Top-Down Proteomics: Bridging the Genotype-to-Phenotype Gap

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