Systemic Lupus Erythematosus News and Research

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Systemic lupus erythematosus (SLE) is the form of the disease that most people are referring to when they say "lupus." The word "systemic" means the disease can affect many parts of the body. The symptoms of SLE may be mild or serious. Although SLE usually first affects people between the ages of 15 and 45 years, it can occur in childhood or later in life as well.

Study of pregnant women with lupus identifies early indicators of pregnancy complications

A study of pregnant women with systemic lupus erythematosus has identified early changes in the RNA molecules present in the blood that could be used to determine the likelihood of them developing preeclampsia.

8 Apr 2019

Researchers developing new tests for early detection, monitoring of lupus nephritis

With $5 million in grants from the National Institutes of Health, two University of Houston biomedical researchers are moving the needle on early detection and monitoring of kidney nephritis, or inflammation, in patients who have Systemic Lupus Erythematosus, known simply as lupus.

2 Apr 2019

Researchers hope blood test that accurately diagnoses fibromyalgia could be available within five years

Ohio State University researchers have evidence that blood samples can reliably detect fibromyalgia, a disease that is often misdiagnosed due to its general symptoms that characterize a number of other conditions.

18 Mar 2019

Psoriasis treatment associated with reduction in coronary artery disease

Researchers have found that treating psoriasis, a chronic inflammatory skin disease, with biologic drugs that target immune system activity can reduce the early plaque buildup that clogs arteries, restricts blood flow, and leads to heart attacks and stroke.

5 Feb 2019

New system for early detection of lupus developed

Autoimmune diseases, such as systemic lupus erythematosus or rheumatoid arthritis, are difficult to diagnose, specially in early stages. Specifically, in the case of lupus, specific antibodies aimed at antigens located in the nucleus of cells appear, including the anti-Ro/SSA.

1 Feb 2019

Immune checkpoint inhibitors induce rheumatic and musculoskeletal diseases

Checkpoint inhibitor therapy is a form of cancer treatment immunotherapy currently under research. The therapy targets immune checkpoints, key regulators of the immune system that stimulate or inhibit its actions, which tumors can use to protect themselves from attacks by the immune system.

18 Jan 2019

Surprising discovery about BH4 may rekindle interest in once-promising pathway

In 2013, renowned Boston Children's Hospital pain researcher Clifford Woolf, MB, BCh, PhD, and chemist Kai Johnsson, PhD, his fellow co-founder at Quartet Medicine, believed they held the key to non-narcotic pain relief.

19 Nov 2018

New approach may lead to better diagnostic techniques for autoimmune disorders

If we really want to know how our body's cells work - or don't work, in the case of disease - we might need to look beyond their genes and even beyond the proteins they are made of.

23 Oct 2018

Study sheds light on lupus's autoimmune origins in precursor cells

In the autoimmune disease systemic lupus erythematosus or SLE, the immune system produces antibodies against parts of the body itself. How cells that produce those antibodies escape the normal "checks and balances" has been unclear, but recent research from Emory University School of Medicine sheds light on a missing link.

11 Oct 2018

New discovery could improve diagnosis and treatment of lupus in black Africans

Two variants of an autoimmune disease that affects thousands but is hard to diagnose are relatively common among black Africans, research shows.

17 Sep 2018

CRI to bestow top honors on three scientists for contributions to cancer immunology and immunotherapy

The Cancer Research Institute, a nonprofit organization dedicated to the discovery and development of immunotherapies for all forms of cancer, will bestow its highest honors on three scientists who have made fundamental contributions to the fields of immunology and cancer immunotherapy.

11 Sep 2018

Imaging with CMR can improve detection of cardiac injury in lupus patients

The number of diagnoses of systemic lupus erythematodes has tripled over the past 45 years - due in part to improved diagnostic methods.

7 Sep 2018

Hypertension drugs may be used to preserve memory of lupus patients

Researchers from The Feinstein Institute for Medical Research have discovered that the activation of brain cells called microglia likely contributes to the memory loss and other cognitive impairments suffered by many patients with systemic lupus erythematosus.

5 Sep 2018

Study shows B cells could play reciprocal roles in pathogenesis of systemic sclerosis

Systemic sclerosis (SSc, also known as scleroderma), a connective tissue disorder of autoimmune etiology, is characterized by excessive fibrosis in the skin and various internal organs.

30 Aug 2018

Study reveals early signs of cardiac impairment in patients with newly diagnosed lupus

Cardiovascular disease is a leading cause of death in patients with lupus, a systemic autoimmune disease. In a new study in Arthritis & Rheumatology—a journal published by Wiley on behalf of the American College of Rheumatology—imaging tests revealed signs of cardiac impairment in patients newly diagnosed with lupus, even before any symptoms of chest discomfort.

2 Aug 2018

UH researchers awarded $2 million grant to unravel link between women and lupus

The chronic inflammatory disease systemic lupus erythematosus, is about nine times more common in women than men, and a University of Houston researcher now has the money to find out why.

1 Aug 2018

Sage launches new web-based tool that helps explore curated genomic analyses of Alzheimer's

Sage Bionetworks announces the launch of the Agora platform an interactive, web-based tool that allows researchers to explore curated genomic analyses of Alzheimer's Disease, including a list of early candidate target nominations for AD.

20 Jul 2018

Study elucidates pathophysiology of systemic lupus erythematosus

Osaka University researchers elucidated the pathophysiology of systemic lupus erythematosus, an autoimmune disorder that causes inflammation and tissue damage.

11 Jul 2018

Study finds new theory for gender differences in occurrence of autoimmune diseases

New findings are now being presented on possible mechanisms behind gender differences in the occurrence of rheumatism and other autoimmune diseases. The study, published in Nature Communications, can be of significance for the future treatment of diseases.

6 Jun 2018

High blood pressure drug may also help prevent onset of type 1 diabetes

A drug commonly used to control high blood pressure may also help prevent the onset of type 1 diabetes in up to 60 percent of those at risk for the disease, according to researchers at the University of Colorado Anschutz Medical Campus and the University of Florida in Gainesville.

15 Feb 2018