Systemic lupus erythematosus (SLE) is the form of the disease that most people are referring to when they say "lupus." The word "systemic" means the disease can affect many parts of the body. The symptoms of SLE may be mild or serious. Although SLE usually first affects people between the ages of 15 and 45 years, it can occur in childhood or later in life as well.
Research supported by the Accelerating Medicines Partnership on Rheumatoid Arthritis and Systemic Lupus Erythematosus provides new insights into tissue damage for these autoimmune conditions.
Nitric oxide (NO) prevents high blood pressure and artery plaque build-up in our body. However, its duplicity is shown when it causes serious inflammatory disease such as systemic lupus erythematosus, Cronh's disease, and rheumatoid arthritis.
The immune system is programmed to rid the body of biological bad guys--like viruses and dangerous bacteria--but its precision isn't guaranteed. In the tens of millions of Americans suffering from autoimmune diseases, the system mistakes normal cells for malicious invaders, prompting the body to engage in self-destructive behavior.
The kidneys of patients living with systemic lupus erythematosus are often under assault, and not all those living with the disease will respond to standard treatment.
Adverse childhood experiences encompass traumas such as abuse, neglect, and household challenges.
Adults with lupus who report having had adverse childhood experiences, such as abuse, neglect and household challenges, report higher disease activity, depression and poorer overall health compared to those without such experiences, according to a study by researchers at UC San Francisco.
A new study examines the barriers to vaccination of immunocompromised children. Findings from the study will be presented during the Pediatric Academic Societies 2019 Meeting, taking place on April 24 - May 1 in Baltimore.
The U.S. Food and Drug Administration today approved Benlysta (belimumab) intravenous infusion for treatment of children with systemic lupus erythematosus – often referred to as simply "lupus" – a serious chronic disease that causes inflammation and damage to various body tissues and organs.
Covalently closed circular RNAs are produced by precursor mRNA back-splicing the exons of thousands of genes in eukaryotes.
It's one of the great mysteries of medicine, and one that affects the lives of millions of people: Why do women's immune systems gang up on them far more than men's do, causing nine times more women to develop autoimmune diseases such as lupus?
A study of pregnant women with systemic lupus erythematosus has identified early changes in the RNA molecules present in the blood that could be used to determine the likelihood of them developing preeclampsia.
With $5 million in grants from the National Institutes of Health, two University of Houston biomedical researchers are moving the needle on early detection and monitoring of kidney nephritis, or inflammation, in patients who have Systemic Lupus Erythematosus, known simply as lupus.
Ohio State University researchers have evidence that blood samples can reliably detect fibromyalgia, a disease that is often misdiagnosed due to its general symptoms that characterize a number of other conditions.
Researchers have found that treating psoriasis, a chronic inflammatory skin disease, with biologic drugs that target immune system activity can reduce the early plaque buildup that clogs arteries, restricts blood flow, and leads to heart attacks and stroke.
Autoimmune diseases, such as systemic lupus erythematosus or rheumatoid arthritis, are difficult to diagnose, specially in early stages. Specifically, in the case of lupus, specific antibodies aimed at antigens located in the nucleus of cells appear, including the anti-Ro/SSA.
Checkpoint inhibitor therapy is a form of cancer treatment immunotherapy currently under research. The therapy targets immune checkpoints, key regulators of the immune system that stimulate or inhibit its actions, which tumors can use to protect themselves from attacks by the immune system.
In 2013, renowned Boston Children's Hospital pain researcher Clifford Woolf, MB, BCh, PhD, and chemist Kai Johnsson, PhD, his fellow co-founder at Quartet Medicine, believed they held the key to non-narcotic pain relief.
If we really want to know how our body's cells work - or don't work, in the case of disease - we might need to look beyond their genes and even beyond the proteins they are made of.
In the autoimmune disease systemic lupus erythematosus or SLE, the immune system produces antibodies against parts of the body itself. How cells that produce those antibodies escape the normal "checks and balances" has been unclear, but recent research from Emory University School of Medicine sheds light on a missing link.
Two variants of an autoimmune disease that affects thousands but is hard to diagnose are relatively common among black Africans, research shows.