Tacrolimus News and Research

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Tacrolimus is a drug used to help reduce the risk of rejection by the body of organ and bone marrow transplants.

New drug combination may prevent GvHD after stem cell transplantation for blood cancers

A drug combination can safely prevent transplanted stem cells, known as a graft, from attacking the recipient's body, allowing them to develop into healthy new blood and immune cells, a new study shows.

14 Dec 2021

Fourth shot of Moderna COVID vaccine improves Delta variant neutralization in kidney transplant patients

New research suggests that a fourth dose of the mRNA-1273 vaccine in kidney transplant recipients improves Delta variant serum neutralization.

1 Dec 2021

Kidney transplant patients are more susceptible to harmless bacterium, finds study

It's a pervasive bacterium found in soil and water that rarely causes disease, but a new national review of nocardia infection in people who have had a kidney transplant shows that when it occurs it most commonly causes pneumonia and brain abscess, and reminds their physicians to stay on the lookout for it, investigators say

11 Oct 2021

Development of SARS-CoV-2 antibody escape variants in an immunocompromised individual

A new study published in mBio discusses the microevolution of SARS-CoV-2.

31 Aug 2021

Immunosuppression in COVID-19 promotes emergence of multiple immune escape mutants

An interesting new study describes the emergence of several such variants from a chronically immunosuppressed COVID-19 patient, who remained infected for over 170 days before clearing the virus.

7 May 2021

Can an immunosuppressive cancer drug promote SARS-CoV-2 entry into host cells?

A new study shows that rapamycin, an immunosuppressive drug used in some cancers, and its analogs, may have an undesirable effect on viral entry into the host cells. This finding could inform their use to treat symptomatic COVID-19.

20 Apr 2021

Study demonstrates that the main creators of SARS-CoV-2 mutations are vaccine-suppressed

A new research paper posted to the medRxiv* preprint server describes the changes in genomic sequence observed during the course of infection in a patient on the drug tacrolimus, along with steroids, both potent immunosuppressants, and who also received convalescent plasma treatment. These mutations were observed to occur within three weeks from infection.

14 Apr 2021

CRISPR screen identifies clinically approved immunosuppressants that could treat coronavirus infections

Researchers in Switzerland and Germany have identified host cell factors required for coronavirus replication that could serve as targets for treatment with clinically-approved drugs.

25 Feb 2021

Long-term steroid treatment may not be necessary for kidney transplant patients

Long-term use of a medication used to treat kidney transplant patients may not be necessary in individuals with low-to-moderate risk of organ rejection, according to the results of a study led by a University of Cincinnati transplant researcher.

24 Feb 2021

Researchers design armored immune cells to attack recurring cancer in liver transplant patients

Duke-NUS Medical School researchers, together with collaborators in Singapore, have designed armored immune cells that can attack recurring cancer in liver transplant patients, while temporarily evading immunosuppressant drugs patients take to avoid organ rejection.

19 Jan 2021

Patients taking immunosuppressive drugs did not have worse COVID-19 outcomes

People taking immunosuppressive drugs to prevent organ transplant rejection or to treat inflammatory or autoimmune diseases do not fare worse than others on average when they are hospitalized with COVID-19, according to a study from researchers at the Johns Hopkins Bloomberg School of Public Health.

7 Jan 2021

New therapeutic strategy designed to improve kidney function after lung transplantation

The Covid-19 pandemic shows the importance of medical research in the treatment of lung diseases. The Medical University of Vienna is renowned the world over in the field of lung transplantation medicine.

23 Dec 2020

Immune-inflammatory mediators indicate that rejection and tissue injury can be avoided with drugs

Immune inflammatory mediators are critical in pathology, transplantation, and regenerative medicine, scientists report in The American Journal of Pathology

22 Dec 2020

High-impact clinical trial results could improve kidney-related medical care

The results of numerous high-impact clinical trials that could affect kidney-related medical care will be presented online during ASN Kidney Week 2020 Reimagined October 19-October 25.

23 Oct 2020

Researchers say that NSAIDs, JAK inhibitors and TNF blockers are safe to use in COVID-19

Amid the coronavirus disease (COVID-19) pandemic, many theories have emerged about the disease and the treatments that can in supportive care. A recent theory emerged that suggests non-steroidal anti-inflammatory drugs (NSAIDs) might exacerbate the symptoms of the novel coronavirus. Now, a new study shows that there is no evidence for or against the use of NSAIDS, particularly ibuprofen, for patients with COVID-19.

1 Apr 2020

New study helps identify drugs that are safe for treating COVID-19

A recent study has found that there is no evidence for or against the use of non-steroidal anti-inflammatory drugs such as ibuprofen for patients with COVID-19.

31 Mar 2020

How cannabis interacts with medications

A new practice guideline published in the journal CMAJ in February 2020 describes five types of drug interactions possible with the use of cannabis. Cannabis is a plant-derived drug containing the psychoactive ingredient delta-9-tetrahydrocannabinol (THC) and non-psychoactive cannabidiol (CBD). These cannabinoids are broken down by the liver enzymes cytochrome P450 C(YP)34A, and CYP2CC9.

2 Mar 2020