Tamoxifen News and Research

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Tamoxifen is a drug used to treat certain types of breast cancer in women and men. It is also used to prevent breast cancer in women who have had ductal carcinoma in situ (abnormal cells in the ducts of the breast) and in women who are at a high risk of developing breast cancer. Tamoxifen is also being studied in the treatment of other types of cancer. It blocks the effects of the hormone estrogen in the breast. Tamoxifen is a type of antiestrogen. Also called tamoxifen citrate.

A new take on growth factor signaling in tamoxifen resistance

Differences in growth factor (GF) signaling may cause the poor prognosis in some breast cancer cases. A new study, published in the open access journal BMC Medical Genomics, suggests that some estrogen receptor-positive breast cancers respond poorly to tamoxifen because of increased GF signaling.

23 Jun 2009

Researchers develop promising new breast cancer diagnostic marker

Indiana University School of Medicine researchers have developed a new breast cancer diagnostic marker that could enable physicians to more easily determine which patients have a less aggressive form of the disease that may not require chemotherapy treatment.

21 Jun 2009

Discovery of protein profile that may predict whether a cancer will be tamoxifen resistant.

Tamoxifen is a widely used and highly successful drug in the treatment of breast cancer, though resistance to tamoxifen is still a concern in recurrent disease (affecting 25-35% of patients), since therapy resistant metastatic tumor cells are a major cause of death.

10 Jun 2009

A new method for breast cancer biomarker discovery

Three researchers from the Virginia Bioinformatics Institute (VBI) at Virginia Tech have developed and evaluated a new one-step bioanalytical approach that allows them to profile in detail complex cellular extracts of proteins. The method has allowed the scientists to look at how the levels of proteins change in breast cancer cells when they are treated with hormones or cancer drugs like tamoxifen.

9 Jun 2009

Prevalence and predictors of antioxidant supplement use during breast cancer treatment

A new study finds that many women with breast cancer take antioxidant supplements while undergoing cancer treatment, even though the consequences of doing so are unknown.

9 Jun 2009

Cisplatin doubles lung cancer survival time in mice

A lung cancer treatment that inhibits nicotine receptors was shown to double survival time in mice, according to Italian researchers.

9 Jun 2009

Popular antidepressants taken with tamoxifen can increase the risk of breast cancer recurrence

A new study found that taking tamoxifen with certain antidepressants more than doubled the risk of breast cancer recurrence in women taking both medications. The antidepressants inhibit an enzyme, CYP2D6, which helps tamoxifen work effectively.

1 Jun 2009

Genetic signature predicts clinical outcomes in certain types of breast cancer

Vanderbilt-Ingram Cancer Center researchers have uncovered a gene signature that may help predict clinical outcomes in certain types of breast cancer.

19 May 2009

Pregabalin shows potential as treatment for hot flashes

A pill used for nerve pain offers women relief from hot flashes, Mayo Clinic researchers report at the 45th Annual Meeting of the American Society of Clinical Oncology (ASCO).

17 May 2009

Loss of stromal protein major new prognostic factor in patients with breast cancer

Reporting online in the American Journal of Pathology, researchers from the Kimmel Cancer Center at Jefferson have implicated the loss of a stromal protein called caveolin-1 as a major new prognostic factor in patients with breast cancer, predicting early disease recurrence, metastasis and breast cancer patient survival.

6 May 2009

Cancer rates among U.S. elderly, minorities set to explode

Over the next 20 years, the number of new cancer cases diagnosed annually in the United States will increase by 45 percent, from 1.6 million in 2010 to 2.3 million in 2030, with a dramatic spike in incidence predicted in the elderly and minority populations, according to research from The University of Texas M. D. Anderson Cancer Center.

29 Apr 2009

Study predicts dramatic growth in cancer rates among US elderly, minorities

29 Apr 2009

Number of women dying from breast cancer hits record low

The number of women dying from breast cancer has fallen to less than 12,000 for the first time since national statistics were recorded almost 40 years ago, Cancer Research UK reveals today.

22 Apr 2009

Statins may be useful in patients with tamoxifen-resistant breast cancer

Breast cancer cells in the laboratory that don't respond to tamoxifen may be producing high amounts of cholesterol in order to provide a kind of shield against the drug, say researchers at Georgetown University Medical Center (GUMC).

20 Apr 2009

Trial of new combination treatment targeting hormone receptor-positive locally advanced breast cancer

Researchers at The Cancer Institute of New Jersey (CINJ) have opened a clinical trial, which aims to evaluate a new treatment for breast cancer in combination with one that is already approved for other types of cancers.

16 Mar 2009

Systematic estimation of breast cancer risk appears justified in postmenopausal women

Screening for breast cancer risk in all postmenopausal women, using a combination of risk factors and breast density, can identify women at high risk of disease, according to systematic literature reviews and meta-analyses reported in the March 10 online issue of the Journal of the National Cancer Institute.

11 Mar 2009

BRCA gene mutations influence a women's views of preventive mastectomy

Women whose cells harbor harmful mutations in the BRCA genes are likely to view preventive mastectomy as the best way to reduce their risk and fears of developing breast cancer, despite other, less drastic options available.

10 Mar 2009

Goserelin improves long-term survival in premenopausal women with early breast cancer

Goserelin, a lutenizing hormone-releasing hormone agonist, reduces the long-term risk of disease recurrence and deaths in premenopausal women with early breast cancer who did not take tamoxifen, according to trial data reported in the February 24 online issue of the Journal of the National Cancer Institute.

24 Feb 2009

Atorvastatin and lovastatin found to be ineffective for breast cancer prevention

Laboratory work in animals showed limited activity when statins were given to prevent breast cancer, according to a report in the February issue of Cancer Prevention Research , a journal of the American Association for Cancer Research.

8 Feb 2009

Breast cancer four times more likely in women with strong family history

Women who have a strong family history of breast cancer are over four times more likely to develop the disease than the general population, according to research published in the British Journal of Cancer.

19 Jan 2009

Tamoxifen News and Research

Further Reading

A new take on growth factor signaling in tamoxifen resistance

Researchers develop promising new breast cancer diagnostic marker

Discovery of protein profile that may predict whether a cancer will be tamoxifen resistant.

A new method for breast cancer biomarker discovery

Prevalence and predictors of antioxidant supplement use during breast cancer treatment

Cisplatin doubles lung cancer survival time in mice

Popular antidepressants taken with tamoxifen can increase the risk of breast cancer recurrence

Genetic signature predicts clinical outcomes in certain types of breast cancer

Pregabalin shows potential as treatment for hot flashes

Loss of stromal protein major new prognostic factor in patients with breast cancer

Cancer rates among U.S. elderly, minorities set to explode

Study predicts dramatic growth in cancer rates among US elderly, minorities

Number of women dying from breast cancer hits record low

Statins may be useful in patients with tamoxifen-resistant breast cancer

Trial of new combination treatment targeting hormone receptor-positive locally advanced breast cancer

Systematic estimation of breast cancer risk appears justified in postmenopausal women

BRCA gene mutations influence a women's views of preventive mastectomy

Goserelin improves long-term survival in premenopausal women with early breast cancer

Atorvastatin and lovastatin found to be ineffective for breast cancer prevention

Breast cancer four times more likely in women with strong family history

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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