Tamoxifen News and Research

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Tamoxifen is a drug used to treat certain types of breast cancer in women and men. It is also used to prevent breast cancer in women who have had ductal carcinoma in situ (abnormal cells in the ducts of the breast) and in women who are at a high risk of developing breast cancer. Tamoxifen is also being studied in the treatment of other types of cancer. It blocks the effects of the hormone estrogen in the breast. Tamoxifen is a type of antiestrogen. Also called tamoxifen citrate.

Lumpectomy plus radiation associated with reduced risk of breast cancer death, study finds

Lumpectomy plus radiation was associated with a small clinical benefit in reduced risk of breast cancer death compared with lumpectomy or mastectomy alone in women with ductal carcinoma in situ, a noninvasive early form of breast cancer.

13 Aug 2018

Breast cancer studies not taking sufficient account of race, socioeconomic factors

Studies of breast cancer risk and treatment outcomes are not taking sufficient account of race/ethnicity, economic status, education level, health insurance status and other social factors, according to scientists at Johns Hopkins Bloomberg School of Public Health.

28 Jun 2018

Study: Long-term estrogen therapy alters microbial composition and activity in the gut

Long-term therapy with estrogen and bazedoxifene alters the microbial composition and activity in the gut, affecting how estrogen is metabolized, a new study in mice found.

20 Jun 2018

Topical gel may lower breast cancer risk in women with dense breast tissue

Women with dense breast tissue soon might be adding a new product to their skincare routine to help them fight breast cancer.

14 Jun 2018

Biotheranostics presents key data for CancerTYPE ID and Breast Cancer Index at ASCO 2018

Biotheranostics, Inc. announces new data from studies for both of its proprietary molecular diagnostic tests, CancerTYPE ID and Breast Cancer Index to be presented on Saturday, June 2nd and Monday, June 4th at the annual meeting of the American Society of Clinical Oncology in Chicago.

8 Jun 2018

Loved one's experience has impact on woman's cancer prevention decisions

A woman's memories of a loved one's experience with cancer could play a significant role in how she approaches breast cancer prevention in her own life, a new study has found.

5 Feb 2018

New clinical practice guideline for using CYP2D6 genotype to guide tamoxifen therapy

An international group of clinicians and scientists representing the Clinical Pharmacogenetics Implementation Consortium published the first-ever clinical practice guideline for using CYP2D6 genotype to guide tamoxifen therapy in Clinical Pharmacology and Therapeutics.

1 Feb 2018

Mount Sinai researchers identify new therapeutic target for ER+ breast cancer

Researchers at the Icahn School of Medicine at Mount Sinai have identified a protein that can be targeted to suppress growth of a common type of breast cancer known as "estrogen receptor positive" (ER+), including ER+ cancers that are resistant to standard treatments.

17 Nov 2017

Women with ER-positive breast cancer face disease recurrence risk years after treatment ends

Even 20 years after a diagnosis, women with a type of breast cancer fueled by estrogen still face a substantial risk of cancer returning or spreading, according to a new analysis from an international team of investigators published in the New England Journal of Medicine.

9 Nov 2017

Gut bacteria composition could predict toxicity of chemotherapy drugs in cancer patients

Albert Einstein College of Medicine researchers report that the composition of people's gut bacteria may explain why some of them suffer life-threatening reactions after taking a key drug for treating metastatic colorectal cancer.

1 Nov 2017

Researchers investigate how component of soy may suppress breast cancer development

A University of Arizona Cancer Center research team is engaged in a series of studies to investigate how genistein, a component of soy foods, might suppress the development of breast cancer.

31 Oct 2017

Dietary combination transforms lethal breast cancers into highly treatable form

Researchers at the University of Alabama at Birmingham have found a dietary combination that transforms the most lethal of all breast cancers into a highly treatable breast cancer.

17 Oct 2017

Researchers identify new genetic test to help predict cancer recurrence

Researchers have discovered a new genetic test which could help predict cancer recurrence - paving the way for more precise, personalized treatments.

21 Sep 2017

QMUL professor receives Cancer Research UK Lifetime Achievement Award

Professor Jack Cuzick from Queen Mary University of London has received the Cancer Research UK Lifetime Achievement Award for his work on cancer prevention and detection.

19 Sep 2017

Link between breast cancer and obesity may be more complex than previously thought

Obese women with large bellies may be at risk of developing a different subtype of breast cancer than those with widespread fat accumulation, according to a new study published in The Oncologist. This suggests that the link between breast cancer and obesity may be more complex than previously thought.

18 Sep 2017

Measuring breast density

Women start off with breasts that are predominately full of milk-producing glandular tissue (“dense tissue”). That tissue slowly changes to fat as the woman ages with an acceleration in that change over menopause.

4 Sep 2017

New drug shows promise to treat women with estrogen positive metastatic breast cancer

Z-endoxifen, a potent derivative of the drug tamoxifen, could itself be a new treatment for the most common form of breast cancer in women with metastatic disease.

31 Aug 2017

Research findings potentially open door to new treatments for eye trauma and retinal disease

Cells within an injured mouse eye can be coaxed into regenerating neurons and those new neurons appear to integrate themselves into the eye's circuitry, new research shows. The findings potentially open the door to new treatments for eye trauma and retinal disease.

28 Aug 2017

Potential drug offers hope for therapy-resistant breast cancer patients

UT Southwestern Simmons Cancer Center researchers have shown that a first-in-class molecule can prevent breast cancer growth when traditional therapies stop working.

8 Aug 2017

Research suggests novel approach for encouraging regeneration in mouse retina

Cells within an injured mouse eye can be coaxed into regenerating neurons and those new neurons appear to integrate themselves into the eye's circuitry, new research shows.

27 Jul 2017