Transcription News and Research

RSS

Data Integrity in the Pharmaceutical Industry

There have been clear statements from regulatory bodies that have increased the pressure on pharmaceutical companies to go electronic with their records and ensure a high level of data integrity in all areas of the pharmaceutical industry.

From Mettler-Toledo International Inc. 29 Jul 2019

Researchers demonstrate positive and negative role of LRH-1 during inflammation

Immune cells prevent bacteria, parasites or viruses from entering the body when, for example, the intestinal epithelium is injured.

26 Jul 2019

Salk study unlocks new way to target hard-to-treat cancers

Now, a new Salk Institute study, published on July 24, 2019, in the journal Science Advances, shows that researchers could target these hard-to-treat cancers by pursuing drugs that keep a cellular "switch," called CREB, from triggering tumor growth.

25 Jul 2019

Slug serves as 'command central' for determining breast stem cell health

A new study published in Cell Reports found that a transcription factor called Slug serves as 'command central' for determining breast stem cell health, regulating both stem cell activity and repair of DNA damage.

17 Jul 2019

Mice study could lead to potential treatment for vestibular disorders

Researchers at the Stanford University School of Medicine have found a way to regenerate hair cells in the inner ears of mice, allowing the animals to recover vestibular function. It's the first time such recovery has been observed in mature mammals.

10 Jul 2019

Engineered stem cells offer new treatment for metastatic bone cancer

Engineered stem cells could help treat metastatic cancers in bone without killing normal surrounding bone.

9 Jul 2019

Study shows potential culprit behind Lupus

A team of researchers at the Emory University School of Medicine show that patients with SLE or lupus, have abnormal activation of B cells, which is part of the body’s immune system

8 Jul 2019

Mice study suggests potential treatment approach for MS in humans

For decades medical researchers have known that an effective way to combat multiple sclerosis (MS) would be to suppress the human immune system, since the debilitating disease is caused by the immune system 'mistakenly' attacking tissues in the spine and brain.

3 Jul 2019

'Scissors' component of CRISPR/Cas9 sometimes gets stuck

In biotech these days, CRISPR/Cas9 is a hot topic, because of its utility as a precise gene editing tool. Before humans repurposed it, CRISPR/Cas9 was a sort of internal immune system bacteria use to defend themselves against phages, or viruses that infect bacteria, by slicing up the phages' DNA.

2 Jul 2019

Study reveals time taken for DNA repair after chemotherapy

In the time it takes for an Amazon Prime delivery to arrive, cells damaged by chemotherapy can almost completely fix their most important DNA. That is the case in the livers of mice at least, according to a new study.

2 Jul 2019

Study uncovers new way to identify driver genes important for cancer progression

Until now, researchers believed recurrent mutations (hotspot mutations) in cancer tumors were the important mutations (driver mutations) that promoted cancer progression.

29 Jun 2019

Researchers find a way to divide patients with ulcerative colitis into groups

Researchers at Karolinska Institutet in Sweden have found a way of using gene expression conserved across species to divide patients with the inflammatory bowel disease ulcerative colitis into two distinct groups.

29 Jun 2019

New strategy may strengthen gut-brain communication

Scientists have developed a strategy that raises the volume of gut-body communication, paving the way for new interventions to improve human health.

28 Jun 2019

Disrupting ChIP Assay Technology with New Advancements

The Chromatrap ChIP technology is a bead-free method of performing ChIP. The potential of the technology emerged from our capabilities in manufacturing porous plastic filters for the filtration and separation of biological materials.

From Chromatrap® - Porvair Sciences Ltd 27 Jun 2019

Study finds new cancer driver which is fast, furious and loud

The Fast and the Furious movie franchise meets the Fast N' Loud television series to define an oncogene that drives 35% of prostate cancers.

27 Jun 2019

Dangerous brain parasite invades host cell, maintains steady nutrient supply

A team of researchers has found that a dangerous type of parasite that affects the brain, maintains a stable supply of essential nutrients as it replicates in the host cell. In an unexpected turn of events, the body itself delivers food to the harmful predator.

20 Jun 2019

ChIP-seq kit maximizes chromatin-antibody binding and capture

Optimizing protein orientation for maximum chromatin-antibody binding and capture enables Chromatrap® ChIP-seq kits to offer market leading sensitivity.

From Chromatrap® - Porvair Sciences Ltd 19 Jun 2019

Mutant bacterial receptor could help identify therapeutic compounds that inhibit quorum sensing

Researchers have developed a new mutant version of a receptor used by a bacterial pathogen for a chemical communication process called quorum sensing, according to a study published June 13 in the open-access journal PLOS Pathogens by Bonnie Bassler of Princeton University, and colleagues.

From PLOS ONE 14 Jun 2019

New research identifies cellular adaptive mechanisms during hypoxic conditions

Circadian rhythms are 24 hour cycles that are guided by exposure to alternating periods of day and night. These cycles affect biological activities in a variety of living organisms which are attuned to the circadian clock.

12 Jun 2019

Researchers identify macrophages' pathway to nurture PTEN-deficient glioblastoma

A common genetic deficiency empowers glioblastoma to broadcast a molecular message to the wrong type of immune cell, summoning macrophages that protect and nurture the brain tumor instead of attacking it, researchers at The University of Texas MD Anderson Cancer Center report in Cancer Cell.

11 Jun 2019