New strategy may strengthen gut-brain communication

NewsGuard 100/100 Score

The communication system between the gut and brain is known as the gut-brain axis and is well established. Now, scientists have developed a strategy that raises the volume of gut-body communication, paving the way for new interventions to improve human health.

Abstract image of the gut-brain axisLightspring | Shutterstock

Researchers at the Alkek Center for Metagenomics and Microbiome Research and the Dan L Duncan Comprehensive Cancer Center at Baylor College of Medicine aimed to study enteroendocrine cells, which are hormone-producing cells in the gastrointestinal tract. These cells are dubbed as vital moderators in the communication between the gut and other parts of the body.

Specialized hormone-producing cells

To land to their findings, the researchers partnered with scientists at the Baylor and Texas Children’s Hospital to formulate a new strategy that an increase in the number of specialized cells.

"Enteroendocrine cells are extremely challenging to study because we just don't have a lot of cells," Dr. Joseph M. Hyser, assistant professor of virology and microbiology and member of the Alkek Center for Metagenomics and Microbiome Research, said in a statement.

"They represent less than 1 percent of all the cells in the intestinal epithelium,” he added.

Enteroendocrine cells are usually found in the wall of the gut. They produce and secrete a hormone that helps maintain numerous body processes, such as controlling food intake, blood glucose levels, and stomach emptying.

They are found in the pancreas, stomach, and gastrointestinal tract. The hormones may be released into the bloodstream to trigger systemic effects and nervous response.

Increasing communication

Enteroendocrine cells (EECs) are specialized epithelial cells responsible for producing molecules that are important for intestinal balance. However, they are limited in number, making it hard for researchers to study them.

To study the cells, the researchers from Hyser and Chang-Graham partnered with other scientists at Baylor and Texas Children’s Hospital to create a technique that can help increase the number of Enteroendocrine cells.

The researchers used a type of human intestinal epithelial cell culture system dubbed as enteroids. To increase the number of the cells, they used previous work on the overexpression of the transcription factor neurogenin-3 drives stem cells in the gut to grow as enteroendocrine cells. Simply put, they used genetically-engineered human intestinal enteroids to express the gene neurogenin-3, which can be induced by doxycycline, creating a molecular switch.

Doxycycline, when added to the cultures, boosted the production of neurogenin 3, triggering the expression of other genes and the development of endocrine enteroid cells. As a result, the number of endocrine enteroid cell production increased from 1 to 40 percent.

Furthermore, the endocrine enteroid cell population, which were expanded, were able to respond to viral and hormonal stimuli as native endocrine cells in the gastrointestinal tract do. They were able to secrete serotonin and other neurotransmitter mediators. Also, their levels increased and became easily detectable.

Promising results

With the results of the new study, the researchers can now create more endocrine cells, which can be seen and examined under the microscope. The researches can now also study and measure physiological responses.

The technique helped develop a system that can help study how the gut communicates with the body through whispered messages. In turn, the system has been used to increase or raise the volume of the chemical whispered messages. Hence, it helps the researches become aware of how the gut interacts with the rest of the body.

It can also help facilitate the research on how the gut affects health and provide a means to formulate and test new interventions to treat various diseases. For instance, researchers can use the technique to analyze how viruses like rotavirus regulate the responses of the endocrine guy populations.

The development of this model system also will allow researchers to begin investigating the complex interactions of the microbiome and diet with enteroendocrine cell function.

Since several of the hormones and effector molecules released by enteroendocrine cells are already targets for the treatment of diseases such as type 2 diabetes and irritable bowel syndrome, we expect this model to aid in identifying novel therapeutics to treat these and other human diseases.”

Prof. Dr. Robert Britton

Angela Betsaida B. Laguipo

Written by

Angela Betsaida B. Laguipo

Angela is a nurse by profession and a writer by heart. She graduated with honors (Cum Laude) for her Bachelor of Nursing degree at the University of Baguio, Philippines. She is currently completing her Master's Degree where she specialized in Maternal and Child Nursing and worked as a clinical instructor and educator in the School of Nursing at the University of Baguio.


Please use one of the following formats to cite this article in your essay, paper or report:

  • APA

    Laguipo, Angela. (2019, June 28). New strategy may strengthen gut-brain communication. News-Medical. Retrieved on May 22, 2024 from

  • MLA

    Laguipo, Angela. "New strategy may strengthen gut-brain communication". News-Medical. 22 May 2024. <>.

  • Chicago

    Laguipo, Angela. "New strategy may strengthen gut-brain communication". News-Medical. (accessed May 22, 2024).

  • Harvard

    Laguipo, Angela. 2019. New strategy may strengthen gut-brain communication. News-Medical, viewed 22 May 2024,


The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News Medical.
Post a new comment

While we only use edited and approved content for Azthena answers, it may on occasions provide incorrect responses. Please confirm any data provided with the related suppliers or authors. We do not provide medical advice, if you search for medical information you must always consult a medical professional before acting on any information provided.

Your questions, but not your email details will be shared with OpenAI and retained for 30 days in accordance with their privacy principles.

Please do not ask questions that use sensitive or confidential information.

Read the full Terms & Conditions.