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TSRI scientists develop new method to enhance drug discovery and protein research

A team led by scientists at The Scripps Research Institute (TSRI) has developed a versatile new method that should enhance the discovery of new drugs and the study of proteins.

20 Jan 2017

Selonterra publishes article on novel APOE4 mechanism linked to Alzheimer’s disease

Selonterra LLC, a biotechnology company discovering therapies for Alzheimer’s disease and Parkinson’s disease announced the publication of the article “Identification of a Nuclear Respiratory Factor 1 Recognition Motif in the Apolipoprotein E Variant APOE4 linked to Alzheimer’s Disease” in Scientific Reports, a peer-reviewed journal of the Nature Publishing Group.

19 Jan 2017

Protein involved in pancreatic cancer development plays more complicated role, study finds

A protein thought to fuel pancreatic cancer development plays a much more complicated role, a new study finds.

18 Jan 2017

Metabolomics and NMR

Bruker has been involved in the Phenome Center network since its beginning. Several years ago, the whole visionary concept of a global phenome network was actually born with Professor Jeremy Nicholson and Bruker BioSpin has been part of it since the early stages.

From Bruker BioSpin - NMR, EPR and Imaging 17 Jan 2017

MGH researchers identify protein that may protect tumor-initiating cells in breast cancer

Massachusetts General Hospital investigators have identified a protein that may play an essential role in maintaining a population of tumor-initiating cells (TICs) -- treatment-resistant cells responsible for cancer recurrence and metastasis -- in breast cancer, as well as a compound that appears to reduce the molecule's ability to protect TICs from the effects of chemotherapy.

17 Jan 2017

Real-time study of medaka fish aboard ISS sheds light on bone metabolism under microgravity

Tokyo Institute of Technology research: Gravitational biology: Real time imaging and transcriptome analysis of medaka aboard space station

11 Jan 2017

Scientists identify molecular pathway in the brain that may help find better treatments for dementia

Rutgers University scientists have discovered a molecular pathway in the brain that may help provide answers to long-term memory problems in the elderly and aid researchers in identifying drug-based therapies to prevent dementia.

11 Jan 2017

MGH researchers identify gene mutations linked to rare congenital condition involving lack of nose

Researchers from Massachusetts General Hospital led a large, international research team that has identified gene mutations associated with a rare congenital condition involving the absence of a nose and often accompanied by defects involving the eye and reproductive systems.

11 Jan 2017

Epigenetic changes favor development of fatty liver in humans and mice

Mice with a strong tendency to obesity already exhibit epigenetic changes at six weeks of age, inducing the liver to amplify its production of the enzyme DPP4 and release it into the circulation. Over the long term, this favors the development of a fatty liver.

9 Jan 2017

Persistent infection in infant reveals mutation that helps bacteria tolerate antibiotic therapy

The quest to understand a prolonged infection in an infant being treated for leukemia has led to the St. Jude Children's Research Hospital discovery of a mutation that allows bacteria to tolerate normally effective antibiotic therapy. The report appears today in the scientific journal mBio.

3 Jan 2017

Researchers develop first non-human primate X-SCID models using genome editing techniques

Researchers affiliated with the Kawasaki INnovation Gateway at SKYFRONT, have successfully generated the first ever non-human primate X-SCID models by using two genome editing techniques. The findings were published in Cell Stem Cell, July 2016.

3 Jan 2017

NIH researchers identify molecular mechanisms that may underlie woman's susceptibility to PMDD

National Institutes of Health researchers have discovered molecular mechanisms that may underlie a woman's susceptibility to disabling irritability, sadness, and anxiety in the days leading up to her menstrual period.

3 Jan 2017

A new strategy to fight prostate cancer

A new study led by scientists from the Florida campus of The Scripps Research Institute (TSRI) sheds light on a signaling circuit in cells that drives therapy resistance in prostate cancer.

30 Dec 2016

Researchers explore how neuronal activity influences CREB dynamics

Neuronal activity mediates the formation of neuronal circuits in the cerebral cortex. These processes are regulated by the transcription factor CREB, which regulates gene expression in neuronal activity-dependent processes.

27 Dec 2016

Fly study shows RNA pathway plays major role in normal health and longevity

Humans and other animals carry rogue sequences of DNA in their genomes called transposable elements. To prevent passing TEs to their offspring, they employ the piRNA pathway in their reproductive organs to block the elements from being active in their sperm and eggs.

21 Dec 2016

MedUni Vienna scientists show that addictive cravings can be detected after death

A protein known as FosB in the reward centre of the brain alters in chronically ill people suffering from an addictive disorder (e.g. heroin addiction): it is genetically modified, split off and shortened.

21 Dec 2016

Researchers creating computer model to track circadian clock

Biology dictates that DNA creates proteins which create - among other things - metabolites, the outputs of metabolism.

20 Dec 2016

CNIC scientists reveal fundamental role of hypoxia response in correct formation of the heart

Scientists at the Centro Nacional de Investigaciones Cardiovasculares Carlos III have demonstrated the fundamental role of the hypoxia response in the correct formation of the heart ventricles.

19 Dec 2016

Replacing missing gut bacteria could help treat children with rare autoimmune disease

Defects in the body's regulatory T cells (T reg cells) cause inflammation and autoimmune disease by altering the type of bacteria living in the gut, researchers from The University of Texas Health Science Center at Houston have discovered.

19 Dec 2016

Researchers identify attractive drug candidate to target glioma tumors

In a paper published today in Cancer Research, researchers: 1) identify a biomarker enzyme associated with aggressive glioma brain tumors, 2) reveal the regulatory mechanism for that enzyme, and 3) demonstrate potent efficacy, using a mouse model of glioma, for a small molecule inhibitor they have developed.

16 Dec 2016

Transcription News and Research

TSRI scientists develop new method to enhance drug discovery and protein research

Selonterra publishes article on novel APOE4 mechanism linked to Alzheimer’s disease

Protein involved in pancreatic cancer development plays more complicated role, study finds

Metabolomics and NMR

MGH researchers identify protein that may protect tumor-initiating cells in breast cancer

Real-time study of medaka fish aboard ISS sheds light on bone metabolism under microgravity

Scientists identify molecular pathway in the brain that may help find better treatments for dementia

MGH researchers identify gene mutations linked to rare congenital condition involving lack of nose

Epigenetic changes favor development of fatty liver in humans and mice

Persistent infection in infant reveals mutation that helps bacteria tolerate antibiotic therapy

Researchers develop first non-human primate X-SCID models using genome editing techniques

NIH researchers identify molecular mechanisms that may underlie woman's susceptibility to PMDD

A new strategy to fight prostate cancer

Researchers explore how neuronal activity influences CREB dynamics

Fly study shows RNA pathway plays major role in normal health and longevity

MedUni Vienna scientists show that addictive cravings can be detected after death

Researchers creating computer model to track circadian clock

CNIC scientists reveal fundamental role of hypoxia response in correct formation of the heart

Replacing missing gut bacteria could help treat children with rare autoimmune disease

Researchers identify attractive drug candidate to target glioma tumors

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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