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Machine learning identifies cancer-driving mutations at CTCF binding sites

Researchers developed a machine learning tool, CTCF-INSITE, to identify mutational hotspots at persistent CTCF binding sites across various cancers, highlighting their role in genomic structure disruption and cancer progression.

7 Jul 2024

Novel antiviral protein SAMD9L blocks HIV-1 and other lentiviruses

Researchers discovered that interferon-stimulated SAMD9L restricts HIV-1 and other lentiviruses by inhibiting viral translation and endosomal trafficking, while SAMD9 enhances HIV-1 replication.

7 Jul 2024

Scientists unveil KLF15 transcription factor's role in white fat cells, opening new paths for obesity therapy

Researchers found that KLF15 is crucial for maintaining white adipocyte properties in subcutaneous fat, and its deletion induces beige adipocyte characteristics, suggesting new obesity treatment pathways.

4 Jul 2024

New study reveals how RNA polymerase opens the transcription bubble in real time

Every living cell transcribes DNA into RNA. This process begins when an enzyme called RNA polymerase (RNAP) clamps onto DNA.

3 Jul 2024

KFF Health News' 'What the Health?': SCOTUS term wraps with a bang

It was a busy year for health-related cases at the Supreme Court. Among other issues, the justices grappled with two abortion cases, a separate case touching on the opioid epidemic, and a case challenging whether localities can bar homeless people from sleeping in public spaces.

3 Jul 2024

RNA splicing modulation as a precision approach for neuroendocrine cancer treatment

Neuroendocrine tumors, including small cell lung cancer and neuroendocrine prostate cancer, are very aggressive with high chances of spreading.

2 Jul 2024

Fibrinogen-like protein 1 plays dual role in liver regeneration and hepatocellular carcinoma recurrence

Hepatocellular carcinoma (HCC), a leading cause of cancer-related mortality globally, exhibits a dismal five-year survival rate of only 18%.

2 Jul 2024

Key transcription factor enhances anthocyanin production in wounded grapevines

A recent study sheds light on the biochemical response of grapevines to wounding stress. It reveals that the transcription factor VvWRKY5 is a key regulator that enhances anthocyanin production, which serves as a protective mechanism for the plant.

2 Jul 2024

Unveiling the epigenetic transformation in insulinomas: Insights into beta cell neoplasia

An experimental study led by Pompeu Fabra University describes the mechanism whereby insulinomas, a rare type of neuroendocrine tumor that affects pancreatic beta cells.

2 Jul 2024

Researchers discover role of particular protein in the development of lupus

A research team of Professor Yoontae Lee and Jiho Park, a PhD candidate, from the Department of Life Sciences at Pohang University of Science and Technology (POSTECH) recently discovered that a particular protein promotes the development of systemic lupus erythematosus (SLE).

1 Jul 2024

Regulatory T cells exist as large, mobile population that travels through body to repair damaged tissue

Researchers investigated populations of regulatory T cells, a type of white blood cell, in various tissues.

1 Jul 2024

Cell division's hidden safety mechanism may influence cancer growth

Before a cell commits fully to the process of dividing itself into two new cells, it may ensure the appropriateness of its commitment by staying for many hours-;sometimes more than a day-;in a reversible intermediate state, according to a discovery by researchers at Weill Cornell Medicine. Their revelation of this fundamental feature of biology includes details of its mechanisms and dynamics, which may inform the development of future therapies targeting cancers and other diseases.

27 Jun 2024

Researchers identify key players in abnormal bone differentiation

A study conducted by researchers at Baylor College of Medicine and collaborating institutions reveals the molecular events leading to osteogenesis imperfecta type V, a form of brittle bone disease caused by a mutation in the gene IFITM5.

27 Jun 2024

Novel approach can make many more bacteria amenable to genetic engineering

Bacteria possess unique traits with great potential for benefiting society. However, current genetic engineering methods to harness these advantages are limited to a small fraction of bacterial species.

26 Jun 2024

Study provides resource for investigating diabetes-linked transcription factors

Scientists have generated a comprehensive map of the gene targets regulated by the transcription factors HNF4A and HNF1A in human pancreatic beta cells and liver cells. Published in the journal Nature Communications, the study revealed common and tissue-specific molecular pathways regulated by HNF4A and HNF1A, two proteins that possess important functions governing the development and function of the pancreas and liver.

26 Jun 2024

Primitive endoderm in early embryos may be key to creating new effective fertility treatments

An unexpectedly versatile and regenerative stem cell in early embryos may be key to creating new effective fertility treatments, suggests a new study in mice from the University of Copenhagen.

24 Jun 2024

Restoring youthful TERT levels reverses aging phenotypes in preclinical models

Researchers at The University of Texas MD Anderson Cancer Center have demonstrated that therapeutically restoring 'youthful' levels of a specific subunit of the telomerase enzyme can significantly reduce the signs and symptoms of aging in preclinical models.

21 Jun 2024

ALS: Newly discovered subtypes and sex differences create new approaches for drugs

Amyotrophic lateral sclerosis, ALS for short, is a mysterious neurodegenerative disease that is almost always fatal.

21 Jun 2024

Study reveals critical role of ADGRF5 in maintaining glomerular filtration barrier integrity

Glomerulus, the fundamental filtering unit of the kidney, is an intricate network of capillaries -; small blood vessels that regulate the movement of ions, water, and metabolites while maintaining impermeability to essential macromolecules such as proteins.

21 Jun 2024

Research finds stem-like T cells are associated with pathogenesis in ulcerative colitis

Researchers investigated whether stem-like T lymphocytes are involved in ulcerative colitis pathogenesis.

21 Jun 2024

Transcription News and Research

Machine learning identifies cancer-driving mutations at CTCF binding sites

Novel antiviral protein SAMD9L blocks HIV-1 and other lentiviruses

Scientists unveil KLF15 transcription factor's role in white fat cells, opening new paths for obesity therapy

New study reveals how RNA polymerase opens the transcription bubble in real time

KFF Health News' 'What the Health?': SCOTUS term wraps with a bang

RNA splicing modulation as a precision approach for neuroendocrine cancer treatment

Fibrinogen-like protein 1 plays dual role in liver regeneration and hepatocellular carcinoma recurrence

Key transcription factor enhances anthocyanin production in wounded grapevines

Unveiling the epigenetic transformation in insulinomas: Insights into beta cell neoplasia

Researchers discover role of particular protein in the development of lupus

Regulatory T cells exist as large, mobile population that travels through body to repair damaged tissue

Cell division's hidden safety mechanism may influence cancer growth

Researchers identify key players in abnormal bone differentiation

Novel approach can make many more bacteria amenable to genetic engineering

Study provides resource for investigating diabetes-linked transcription factors

Primitive endoderm in early embryos may be key to creating new effective fertility treatments

Restoring youthful TERT levels reverses aging phenotypes in preclinical models

ALS: Newly discovered subtypes and sex differences create new approaches for drugs

Study reveals critical role of ADGRF5 in maintaining glomerular filtration barrier integrity

Research finds stem-like T cells are associated with pathogenesis in ulcerative colitis

E-Cigarettes and Ethanol: A forensic Perspective on Vaping

Understanding Consumer-Consented Data to Optimize Digital Health Programs

The Future is Wearable: Advancing Human Health Through Portable Spectroscopy

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