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Understanding how chikungunya virus affects the brain and body

The chikungunya virus, transmitted by Aedes aegypti and Aedes albopictus mosquitoes and responsible for more than 900 deaths in Brazil since it arrived around ten years ago, is capable of spreading through the blood, reaching multiple organs and crossing the blood-brain barrier, which protects the central nervous system.

12 Mar 2024

Protein Kdm1a plays a crucial role in preserving neuronal identity, study shows

Epigenetic processes allow different cell types to emerge from a single genome. Throughout development, cells differentiate and acquire distinct characteristics by expressing the same genome in different ways.

12 Mar 2024

Groundbreaking study unveils sex-specific genetic influences on blood pressure

Genetic heterogeneity of blood pressure (BP) effects between sexes.

12 Mar 2024

Researchers forge new path to combat viruses and cancers with helicase inhibitors

Helicases are enzymes that unwind DNA and RNA. They're central to cellular life, implicated in a number of cancers and infections-;and, alas, extraordinarily difficult to target with drugs.

9 Mar 2024

Study unravels FOXO1's influence on blood vessel development

The human vascular system, a complex network of blood vessels, plays an essential role in maintaining health. Understanding the molecular mechanisms underlying vascular development is important for tackling age-related disorders.

9 Mar 2024

The effects of high maternal folate intake on the health outcomes of offspring

Researchers summarized what is known about the effects of excessive folic acid (FA) supplementation for mothers on children.

8 Mar 2024

New method simplifies production of limb progenitor cells from fibroblasts

In a collaborative study, researchers from Kyushu University and Harvard Medical School have identified proteins that can turn or "reprogram" fibroblasts -; the most commonly found cells in skin and connective tissue -; into cells with similar properties to limb progenitor cells.

4 Mar 2024

Unlocking the secrets of T follicular helper cells for better treatment strategies

T follicular helper cells (Tfh) are essential for strong antibody-mediated reactions of our immune system during infections and vaccinations. However, if they get out of control, this can cause diseases such as autoimmunity, allergies or cancer.

1 Mar 2024

Breakthrough gene silencing method slashes cholesterol for a year in mice, no DNA damage

Researchers developed an engineered transcriptional repressor that durably silences the Pcsk9 gene in mice, reducing cholesterol levels for up to a year with a single treatment, showcasing a potential breakthrough in genetic disorder treatments without the risks of DNA mutation.

29 Feb 2024

Association of estrogen-containing menopause hormonal therapy with COVID-19 mortality

Researchers evaluated coronavirus disease 2019 (COVID-19)-related mortality among perimenopausal women.

29 Feb 2024

UCLA researchers uncover dual role of GAN gene in neurological disorder, head and neck cancer

Researchers from the UCLA Health Jonsson Comprehensive Cancer Center show for the first time that a gene usually linked to giant axonal neuropathy, a rare and severe neurological condition, also plays a role in inhibiting aggressive tumor cell growth in head and neck cancers.

29 Feb 2024

Scientists uncover a new doorway for SARS-CoV-2 into human cells

Research identifies the human transferrin receptor as an alternative pathway for SARS-CoV-2 infection, offering potential new targets for COVID-19 therapies.

27 Feb 2024

Study reveals distinct molecular features of proximal and distal colon cancers

The colon is often thought of as one organ, but the right and left parts of the colon have different molecular features in cancers.

27 Feb 2024

Zika virus detected in Singapore neighborhood: 15 cases spark renewed vigilance

Entomological, wastewater, and case surveillance of the Zika virus (ZIKV) in Singapore.

26 Feb 2024

Advancing gene regulatory network inference with causal discovery and graph neural networks

Gene regulatory networks (GRNs) depict the regulatory mechanisms of genes within cellular systems as a network, offering vital insights for understanding cell processes and molecular interactions that determine cellular phenotypes.

23 Feb 2024

New study defines clinical phenotype of Post-infectious ME/CFS, highlighting unique biomarker insights

The pathophysiological mechanisms of PI myalgic encephalitis/chronic fatigue syndrome (ME/CFS).

23 Feb 2024

Females' immune system edges out males but at a cost of higher autoimmune risk

A review article highlights how two X chromosomes in females influence immune system composition and function, leading to faster infection clearance and stronger vaccination responses but also a higher risk of autoimmune diseases.

22 Feb 2024

Elevated IFN-γ levels linked to long COVID, study finds

Researchers find elevated IFN-γ levels in long COVID patients, with symptom improvement correlating with decreased IFN-γ, suggesting it as a potential biomarker and target for therapeutic intervention.

22 Feb 2024

New immunotherapy target activin receptor 1C shows promise against cancer

Drugs that target a receptor on immune cells called activin receptor 1C may combat tumor-induced immune suppression and help patients' immune systems fight back against cancer, according to a study by investigators at the Johns Hopkins Kimmel Cancer Center and its Bloomberg~Kimmel Institute for Cancer Immunotherapy.

22 Feb 2024

Can dietary patterns impact stomach cancer risk?

Eating patterns and indices related to gastric cancer and explored their association with stomach cancer risk.

22 Feb 2024

Transcription News and Research

Understanding how chikungunya virus affects the brain and body

Protein Kdm1a plays a crucial role in preserving neuronal identity, study shows

Groundbreaking study unveils sex-specific genetic influences on blood pressure

Researchers forge new path to combat viruses and cancers with helicase inhibitors

Study unravels FOXO1's influence on blood vessel development

The effects of high maternal folate intake on the health outcomes of offspring

New method simplifies production of limb progenitor cells from fibroblasts

Unlocking the secrets of T follicular helper cells for better treatment strategies

Breakthrough gene silencing method slashes cholesterol for a year in mice, no DNA damage

Association of estrogen-containing menopause hormonal therapy with COVID-19 mortality

UCLA researchers uncover dual role of GAN gene in neurological disorder, head and neck cancer

Scientists uncover a new doorway for SARS-CoV-2 into human cells

Study reveals distinct molecular features of proximal and distal colon cancers

Zika virus detected in Singapore neighborhood: 15 cases spark renewed vigilance

Advancing gene regulatory network inference with causal discovery and graph neural networks

New study defines clinical phenotype of Post-infectious ME/CFS, highlighting unique biomarker insights

Females' immune system edges out males but at a cost of higher autoimmune risk

Elevated IFN-γ levels linked to long COVID, study finds

New immunotherapy target activin receptor 1C shows promise against cancer

Can dietary patterns impact stomach cancer risk?

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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