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Scientists identify papain-like protease inhibitor against COVID-19

In a new study, researchers identified a papain-like protease inhibitor for the treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections.

25 Jul 2022

New transport system exemplifies the potential of a de novo design of peptides and proteins

A novel peptide developed at the Universities of Bayreuth and Bristol is eminently suited for the targeted transport of molecules, for example of active substances and dyes, into the cells of mammals.

14 Jul 2022

MaxCyte signs strategic platform license with LG Chem to advance its allogeneic CAR-T programs

MaxCyte, Inc., a leading commercial cell-engineering company focused on providing enabling platform technologies to advance innovative cell-based research as well as next-generation cell therapeutic discovery, development and commercialization, today announces the signing of a strategic platform license (SPL) with LG Chem Ltd., a globally diversified chemical company established in petrochemical, advanced materials and bio-technology, aiming to create new value for its customers based on science.

From MaxCyte, Inc. 13 Jul 2022

SARS-CoV-2 spike protein downregulates ACE2 expression

In a new study, researchers observed the downregulation of ACE2 by SARS-CoV-2.

11 Jul 2022

Lipid-peptide nanocomplexes offer new mRNA platform

A new paper reports the methodical development of lipid-peptide nanocomplexes as a delivery vehicle for messenger ribonucleic acid molecules to the tumor cell, in vitro and in vivo.

27 Jun 2022

SARS-CoV-2 evades natural killer cell cytotoxic responses

In a recent study posted to the bioRxiv* preprint server, researchers at Stanford University School of Medicine revealed the mechanism via severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) escapes natural killer (NK) cell cytotoxic reactions.

22 Jun 2022

Study finds traditional African drug inhibits growth of SARS-CoV-2 infection

Researchers evaluated the efficacy of PHELA, a traditional African drug, against SARS-CoV-2 in vitro.

21 Jun 2022

SARS-CoV-2 damages cilia

Researchers determine whether the interaction between ORF10 and ZYG11B promotes the dissemination of SARS-CoV-2.

15 Jun 2022

SARS-CoV-2 mRNA vaccines do not stimulate interferon stimulatory gene expression in Aicardi Goutières Syndrome patients

A new study aimed to evaluate the immunostimulatory potential of mRNA vaccines in AGS patients.

23 May 2022

Study reports SARS-CoV-2 accessory proteins downregulate MHC-I expression using distinct mechanisms

Researchers observed SARS-CoV-2 downregulates the expression of MHC class I molecules.

23 May 2022

Downregulation of MHC-I surface expression by SARS-CoV-2 accessory proteins

Researchers analyze the mechanisms by which two SARS-CoV-2 accessory proteins, ORF3a and ORF7a, can downregulate the expression of MHC-I.

19 May 2022

SARS-CoV-2 N-terminal domain modulates S1/S2 cleavage and spike-mediated functions

In a recent study posted to the bioRxiv* preprint server, researchers explored the role of the N-terminal domain (NTD) of the severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) spike (S) protein in SARS-CoV-2 fusion with the host membranes and coronavirus disease 2019 (COVID-19).

12 May 2022

Investigating the role of cyclins and cyclin-dependent kinases in host restriction of SARS-CoV-2 infection

Researchers explore a novel method to isolate monoclonal antibodies from COVID-19 convalescents infected with SARS-CoV-2 variants

Researchers developed a novel high-throughput method to obtain monoclonal antibodies from COVID-19 individuals infected with SARS-CoV-2 ancestral strain Wuhan-Hu-1 and the Beta or Gamma variants.

1 Apr 2022

Transfection News and Research

Scientists identify papain-like protease inhibitor against COVID-19

New transport system exemplifies the potential of a de novo design of peptides and proteins

MaxCyte signs strategic platform license with LG Chem to advance its allogeneic CAR-T programs

SARS-CoV-2 spike protein downregulates ACE2 expression

Lipid-peptide nanocomplexes offer new mRNA platform

SARS-CoV-2 evades natural killer cell cytotoxic responses

Study finds traditional African drug inhibits growth of SARS-CoV-2 infection

SARS-CoV-2 damages cilia

SARS-CoV-2 mRNA vaccines do not stimulate interferon stimulatory gene expression in Aicardi Goutières Syndrome patients

Study reports SARS-CoV-2 accessory proteins downregulate MHC-I expression using distinct mechanisms

Downregulation of MHC-I surface expression by SARS-CoV-2 accessory proteins

SARS-CoV-2 N-terminal domain modulates S1/S2 cleavage and spike-mediated functions

Investigating the role of cyclins and cyclin-dependent kinases in host restriction of SARS-CoV-2 infection

SARS-CoV-2 variants are not evolving to escape from T cell-mediated immunity

Proximity labeling to identify high-confidence SARS-CoV-2 interactors

Multivalent messenger ribonucleic acid-lipid nanoparticle vaccines against SARS-CoV-2

Artificial circular RNAs found to bypass cellular antiviral responses

CRISPR/Cas9 deletions induce adverse on-target genomic effects

Recent advances in non-viral nano-vector delivery of CRISPR/Cas9 genome editing payloads

Researchers explore a novel method to isolate monoclonal antibodies from COVID-19 convalescents infected with SARS-CoV-2 variants

The past, present and future of automation and digitalization in the life sciences laboratory

Arxspan BioDrive: A Versatile Solution for Molecular Biology

One Health, One Mission: The World Organisation for Animal Health on the AMR Frontline

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