Transfection News and Research

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A fast and powerful method for the production of SARS-CoV-2 virus-like particles in insect cells

Researchers presented the direct plasmid transfection method for SARS-CoV-2 virus-like particle production in insect cells and applied the VLPs to evaluate the efficacy of monoclonal antibodies and vaccinated donor sera.

26 Sep 2022

Signal transduction via the EGFR pathway likely to be involved in lenvatinib resistance

The multitargeted tyrosine kinase inhibitor (MKI), lenvatinib, is widely used to treat advanced and metastatic thyroid cancer. However, the molecular mechanisms by which thyroid cancer cells become resistant to lenvatinib remain poorly understood. In this study, we demonstrated, for the first time, that activation of the epidermal growth factor receptor (EGFR)-mediated signaling pathway is involved in lenvatinib resistance in thyroid cancer cells.

14 Sep 2022

Novel method for gene editing of hPSCs yields up to 84% knockout efficiency

A Penn State-led team of interdisciplinary researchers has developed techniques to improve the efficiency of CRISPR-Cas9, the genome editing technique that earned the Nobel Prize in 2020.

9 Sep 2022

Researchers demonstrate improved culture of primate induced pluripotent stem cells

The following study transplanted iPSCs derived from two NHP species, chimpanzee and pigtailed macaque, into blastocysts from another NHP species – the rhesus macaque.

1 Sep 2022

Cell Counting Without Slides to Reduce Waste and Cost

Until recently, cells were typically counted on a reusable quartz hemocytometer.

From DeNovix Inc. 1 Sep 2022

Novel mechanism identified that SARS-CoV-2 uses to suppress antiviral responses to make the cell more permissive to infection

Researchers assessed the impact of SARS-CoV-2 ORF-6 on innate immune signaling.

30 Aug 2022

What is the potential role of sphingosine kinase inhibitors as antiviral agents?

In a new study, researchers explored sphingosine kinases inhibitors and characterized the role of SKs in Ebola virus (EBOV) entry.

16 Aug 2022

A combined influenza and COVID-19 mRNA vaccine

A combined mRNA vaccine is capable of inducing broad and durable protection against co-infection with SARS-CoV-2 and IAV,

3 Aug 2022

DeNovix launches nuclei counting apps for CellDrop Automated Cell Counters

DeNovix Inc, the manufacturer of the award-winning CellDrop Automated Cell Counter, has developed two dedicated nuclei counting apps capable of differentiating isolated nuclei and intact cells from debris.

From DeNovix Inc. 3 Aug 2022

Scientists identify papain-like protease inhibitor against COVID-19

In a new study, researchers identified a papain-like protease inhibitor for the treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections.

25 Jul 2022

New transport system exemplifies the potential of a de novo design of peptides and proteins

A novel peptide developed at the Universities of Bayreuth and Bristol is eminently suited for the targeted transport of molecules, for example of active substances and dyes, into the cells of mammals.

14 Jul 2022

MaxCyte signs strategic platform license with LG Chem to advance its allogeneic CAR-T programs

MaxCyte, Inc., a leading commercial cell-engineering company focused on providing enabling platform technologies to advance innovative cell-based research as well as next-generation cell therapeutic discovery, development and commercialization, today announces the signing of a strategic platform license (SPL) with LG Chem Ltd., a globally diversified chemical company established in petrochemical, advanced materials and bio-technology, aiming to create new value for its customers based on science.

From MaxCyte, Inc. 13 Jul 2022

SARS-CoV-2 spike protein downregulates ACE2 expression

In a new study, researchers observed the downregulation of ACE2 by SARS-CoV-2.

11 Jul 2022

Lipid-peptide nanocomplexes offer new mRNA platform

A new paper reports the methodical development of lipid-peptide nanocomplexes as a delivery vehicle for messenger ribonucleic acid molecules to the tumor cell, in vitro and in vivo.

27 Jun 2022

SARS-CoV-2 evades natural killer cell cytotoxic responses

In a recent study posted to the bioRxiv* preprint server, researchers at Stanford University School of Medicine revealed the mechanism via severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) escapes natural killer (NK) cell cytotoxic reactions.

22 Jun 2022

Transfection News and Research

A fast and powerful method for the production of SARS-CoV-2 virus-like particles in insect cells

Signal transduction via the EGFR pathway likely to be involved in lenvatinib resistance

Novel method for gene editing of hPSCs yields up to 84% knockout efficiency

Researchers demonstrate improved culture of primate induced pluripotent stem cells

Cell Counting Without Slides to Reduce Waste and Cost

Novel mechanism identified that SARS-CoV-2 uses to suppress antiviral responses to make the cell more permissive to infection

What is the potential role of sphingosine kinase inhibitors as antiviral agents?

A combined influenza and COVID-19 mRNA vaccine

DeNovix launches nuclei counting apps for CellDrop Automated Cell Counters

Scientists identify papain-like protease inhibitor against COVID-19

New transport system exemplifies the potential of a de novo design of peptides and proteins

MaxCyte signs strategic platform license with LG Chem to advance its allogeneic CAR-T programs

SARS-CoV-2 spike protein downregulates ACE2 expression

Lipid-peptide nanocomplexes offer new mRNA platform

SARS-CoV-2 evades natural killer cell cytotoxic responses

Study finds traditional African drug inhibits growth of SARS-CoV-2 infection

SARS-CoV-2 damages cilia

SARS-CoV-2 mRNA vaccines do not stimulate interferon stimulatory gene expression in Aicardi Goutières Syndrome patients

Study reports SARS-CoV-2 accessory proteins downregulate MHC-I expression using distinct mechanisms

Downregulation of MHC-I surface expression by SARS-CoV-2 accessory proteins

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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