Translation News and Research

RSS

Researchers develop safe, potent mRNA vaccine adjuvants that can elicit effective immune response

Production of conventional vaccines, which involves the use of live-attenuated or purified protein subunits of pathogens, is a long and complex process. Nucleic acid vaccines are safer alternatives, and allow easy adjustment of antigen to target specific pathogens.

9 Feb 2018

Researchers test effectiveness of investigational drug in treating diastolic dysfunction of the heart

Researchers at the University of Colorado School of Medicine have identified a potential treatment target for patients with a common type of heart failure.

8 Feb 2018

Researchers win $6.5 million NIH grant to personalize diagnosis and treatment of psoriasis

An experienced interdisciplinary team of psoriasis and computational researchers from Case Western Reserve University School of Medicine and University Hospitals Cleveland Medical Center has received a $6.5M, 5-year grant from the National Institute of Arthritis, Musculoskeletal and Skin Diseases.

29 Jan 2018

Discovery may advance stem cell therapies, gene-targeting treatments for neurological diseases

New research from Sanford Burnham Prebys Medical Discovery Institute is among the first to describe how an mRNA modification impacts the life of neural stem cells.

24 Jan 2018

Judge orders new Olympus trial over superbug death

A Seattle judge said Olympus Corp. failed to properly disclose internal emails that raised safety concerns about a redesigned medical scope as early as 2008, several years before the device was publicly tied to deadly superbug outbreaks.

19 Jan 2018

EXD2 enzyme facilitates protein production in mitochondria

Researchers from the Genomic Instability and Cancer Laboratory at Institute for Research in Biomedicine (IRB Barcelona) have identified a key role for EXD2 in protein production in the mitochondria, the cellular organelles responsible for the majority of energy generation.

17 Jan 2018

The Salk Institute and Indivumed collaborate for cutting-edge cancer research

The Salk Institute, which hosts a National Cancer Institute-designated cancer center and Indivumed GmbH, a world leading cancer research company today announce a multi-year strategic alliance to secure, preserve and analyze human cancer tissue and annotated clinical data from consenting patients around the world, enabling the most cutting-edge basic and translational research in cancer.

16 Jan 2018

Study reveals how dengue virus replicates without triggering the body's defenses

A new study reveals how dengue virus manages to reproduce itself in an infected person without triggering the body's normal defenses. Duke researchers report that dengue pulls off this hoax by co-opting a specialized structure within host cells for its own purposes, like a lazy roommate sneaking bits of his laundry into the communal wash.

11 Jan 2018

New blood stabilization method prolongs lifespan of blood samples for CTC profiling

A new blood stabilization method, developed at the Massachusetts General Hospital Center for Engineering in Medicine, significantly prolongs the lifespan of blood samples for microfluidic sorting and transcriptome profiling of rare circulating tumor cells (CTCs), living cancer cells carried in the bloodstream.

9 Jan 2018

Genetic differences can influence efficiency of medicines

Medicines do not follow the one size fits all principle, because genetic differences can influence their efficiency.

5 Jan 2018

New total-body PET scanner could revolutionize patient diagnosis and care

The new total-body PET/CT scanner could revolutionize our understanding and treatment of disease through analysis of better imaging data from the whole body.

3 Jan 2018

Researchers develop highly precise sensor-based surgical robot for spinal operations

Researchers from the University of Bern, Inselspital, Bern University Hospital and the Swiss Center for Electronics and Microtechnology develop a high-precision, sensor-based surgical robot for spinal operations together with industry partners.

21 Dec 2017

Study finds new way to explain hearing loss caused by cancer drug

Scientists have found a new way to explain the hearing loss caused by cisplatin, a powerful drug used to treat many forms of cancer. Using a highly sensitive technique to measure and map cisplatin in mouse and human inner ear tissues, researchers found that forms of cisplatin build up in the inner ear.

20 Dec 2017

Study reveals biology behind why muscle stem cells respond differently to aging or injury

A new study led by researchers at Sanford Burnham Prebys Medical Discovery Institute describes the biology behind why muscle stem cells respond differently to aging or injury.

15 Dec 2017

Chronic Kidney Disease Audit finds wide variations in coding of CKD patients in primary care

Sustainability and Transformation Partnerships, Clinical Commissioning Groups and primary care practices must all work together to improve outcomes for patients with Chronic Kidney Disease (CKD), according to the national Chronic Kidney Disease Audit published today.

15 Dec 2017

IU scientists discover way to make drug treatment more successful against malaria

Indiana University School of Medicine researchers have identified a way to block the ability of parasites that cause malaria to shield themselves against drug treatments in infected mice--a finding that could lead to the development of new approaches to combat this deadly disease in humans.

14 Dec 2017

Autism traits linked to risk of depression, suicidal thoughts in people with psychosis

People with autism traits who have psychosis are at a greater risk of depression and thoughts of suicide, new research has found.

14 Dec 2017

Researchers find new role for SHARPIN protein in melanoma growth

Researchers at Sanford Burnham Prebys Medical Discovery and the Technion in Israel have found a new role for the SHARPIN protein. In addition to being one of three proteins in the linear ubiquitin chain assembly complex, regulating NFκB and other inflammatory molecules, SHARPIN modulates PRMT5, an epigenetic master switch that controls several proteins linked to melanoma. The research was published in The Journal of Clinical Investigation.

12 Dec 2017

Research brings scientists one step closer to understanding development of ALS

University of Michigan-led research brings scientists one step closer to understanding the development of neurodegenerative disorders such as ALS.

8 Dec 2017

Research findings offer path for drug discovery to treat hyperaldosteronism

A new study led by researchers at Sanford Burnham Prebys Medical Discovery Institute, in collaboration with researchers at Eunice Kennedy Shriver National Institute of Child Health and Human Development, part of the National Institutes of Health, identifies a mechanism that explains the development of hyperaldosteronism.

7 Dec 2017